A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine Is Catalyzed by CYP2C8 But Prior Glucuronidation of Desloratadine by UDP-Glucuronosyltransferase 2B10 Is an Obligatory Requirement

Faraz Kazmi; Joanna E. Barbara; Phyllis Yerino; Andrew Parkinson

doi:10.1124/dmd.114.062620

Research ArticleArticle

A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine Is Catalyzed by CYP2C8 But Prior Glucuronidation of Desloratadine by UDP-Glucuronosyltransferase 2B10 Is an Obligatory Requirement

Faraz Kazmi, Joanna E. Barbara, Phyllis Yerino and Andrew Parkinson

Drug Metabolism and Disposition April 2015, 43 (4) 523-533; DOI: https://doi.org/10.1124/dmd.114.062620

Faraz Kazmi

XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.)

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Joanna E. Barbara

XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.)

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Phyllis Yerino

XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.)

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Andrew Parkinson

XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.)

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Drug Metabolism and Disposition

Vol. 43, Issue 4

1 Apr 2015

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Research ArticleArticle

3-Hydroxydesloratadine Formation by UGT2B10 and CYP2C8

Faraz Kazmi, Joanna E. Barbara, Phyllis Yerino and Andrew Parkinson

Drug Metabolism and Disposition April 1, 2015, 43 (4) 523-533; DOI: https://doi.org/10.1124/dmd.114.062620

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Research ArticleArticle

3-Hydroxydesloratadine Formation by UGT2B10 and CYP2C8

Faraz Kazmi, Joanna E. Barbara, Phyllis Yerino and Andrew Parkinson

Drug Metabolism and Disposition April 1, 2015, 43 (4) 523-533; DOI: https://doi.org/10.1124/dmd.114.062620

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A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine Is Catalyzed by CYP2C8 But Prior Glucuronidation of Desloratadine by UDP-Glucuronosyltransferase 2B10 Is an Obligatory Requirement

DMD articles become freely available 12 months after publication, and remain freely available for 5 years.

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3-Hydroxydesloratadine Formation by UGT2B10 and CYP2C8

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