Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine Is Catalyzed by CYP2C8 But Prior Glucuronidation of Desloratadine by UDP-Glucuronosyltransferase 2B10 Is an Obligatory Requirement

Faraz Kazmi, Joanna E. Barbara, Phyllis Yerino and Andrew Parkinson
Drug Metabolism and Disposition April 2015, 43 (4) 523-533; DOI: https://doi.org/10.1124/dmd.114.062620
Faraz Kazmi
XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Faraz Kazmi
Joanna E. Barbara
XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Phyllis Yerino
XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew Parkinson
XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Article Information

vol. 43 no. 4 523-533
DOI 
https://doi.org/10.1124/dmd.114.062620
PubMed 
25595597

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 11, 2014
  • Accepted January 14, 2015
  • Published online February 20, 2015.

Article Versions

  • Earlier version (January 16, 2015 - 05:12).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Faraz Kazmi,
  2. Joanna E. Barbara,
  3. Phyllis Yerino, and
  4. Andrew Parkinson
  1. XenoTech, LLC, Lenexa, Kansas (F.K., J.E.B., P.Y.); and XPD Consulting, Shawnee, Kansas (A.P.)
  1. Address correspondence to:
    Faraz Kazmi, XenoTech, LLC, 16825 West 116th Street, Lenexa, KS 66219. E-mail: fkazmi{at}xenotechllc.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: January 2015 to May 2022

AbstractFullPdf
Jan 20154200204
Feb 201539413111
Mar 201556723117
Apr 20151762554
May 20151861856
Jun 2015951331
Jul 2015110723
Aug 2015731521
Sep 2015742029
Oct 2015871626
Nov 201542616
Dec 201535919
Jan 201646817
Feb 201629617
Mar 2016261243
Apr 2016573336
May 2016392833
Jun 2016223135
Jul 2016301742
Aug 2016452145
Sep 2016331927
Oct 201665042
Nov 201656356
Dec 201664446
Jan 201744224
Feb 201783933
Mar 201745151
Apr 201713529
May 201783030
Jun 201772724
Jul 201732028
Aug 201773418
Sep 201783927
Oct 201744232
Nov 2017186037
Dec 20171110431
Jan 201896642
Feb 2018105632
Mar 201847928
Apr 201845624
May 201806425
Jun 201867428
Jul 201873626
Aug 2018104332
Sep 201887132
Oct 201835224
Nov 201835835
Dec 201895728
Jan 201955326
Feb 201963827
Mar 201953339
Apr 2019127339
May 201975534
Jun 201954721
Jul 201913638
Aug 2019106135
Sep 2019134235
Oct 201915826
Nov 201933524
Dec 201975517
Jan 202013722
Feb 202006417
Mar 202085318
Apr 202054129
May 202022226
Jun 202015520
Jul 202044210
Aug 202076018
Sep 202073920
Oct 202034512
Nov 202053823
Dec 2020149128
Jan 202176722
Feb 2021254319
Mar 20216485
Apr 202165125
May 20217574
Jun 202141167
Jul 202145119
Aug 202167123
Sep 2021401615
Oct 20213284
Nov 20213548
Dec 20214784
Jan 20222829
Feb 202235511
Mar 202232710
Apr 20221623
May 20221622

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 43 (4)
Drug Metabolism and Disposition
Vol. 43, Issue 4
1 Apr 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
A Long-Standing Mystery Solved: The Formation of 3-Hydroxydesloratadine Is Catalyzed by CYP2C8 But Prior Glucuronidation of Desloratadine by UDP-Glucuronosyltransferase 2B10 Is an Obligatory Requirement
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

3-Hydroxydesloratadine Formation by UGT2B10 and CYP2C8

Faraz Kazmi, Joanna E. Barbara, Phyllis Yerino and Andrew Parkinson
Drug Metabolism and Disposition April 1, 2015, 43 (4) 523-533; DOI: https://doi.org/10.1124/dmd.114.062620

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

3-Hydroxydesloratadine Formation by UGT2B10 and CYP2C8

Faraz Kazmi, Joanna E. Barbara, Phyllis Yerino and Andrew Parkinson
Drug Metabolism and Disposition April 1, 2015, 43 (4) 523-533; DOI: https://doi.org/10.1124/dmd.114.062620
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Role of Human MSRA on Sulindac Activation
  • Determination of Acyl-, O-, and N-Glucuronide
  • Uptake as the RDS in Pevonedistat Hepatic Clearance
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics