Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (H.Y.); Takeda Pharmaceuticals International Co., Cambridge, Massachusetts (S.K.B.); Vertex Pharmaceuticals, San Diego, California (W.C.); Merck Research Laboratories, West Point, Pennsylvania (D.C.); Daiichi Sankyo, Inc. Edison, New Jersey (L.H.); Bristol-Myers Squibb, Princeton, New Jersey (W.G.H.); Genentech, South San Francisco, California (J.M.); Eisai Pharmaceuticals, Andover, Massachusetts (W.G.L.); AbbVie, North Chicago, Illinois (A.J.L.); Janssen Research and Development, Spring House, Pennsylvania (H.-K.L.); GlaxoSmithKline, Research Triangle Park, North Carolina (C.M.); Biogen Idec, Cambridge, Massachusetts (C.P.); Celgene Corporation, Summit, New Jersey (S.S.); Pfizer Inc., Groton, Connecticut (S.T.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (A.U.); AstraZeneca, Waltham, Massachusetts (R.L.W.); Department of Drug Metabolism and Pharmacokinetics, Roche Palo Alto, Palo Alto, California (B.W.); and Sanofi, Bridgewater, New Jersey (Z.Z.)