Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Rapid CommunicationAccelerated Communication

PBPK Modeling to Unravel Nonlinear Pharmacokinetics of Verapamil to Estimate the Fractional Clearance for Verapamil N-Demethylation in the Recirculating Rat Liver Preparation

Qi Joy Yang, Luqin Si, Hui Tang, Helle H. Sveigaard, Edwin C. Y. Chow and K. Sandy Pang
Drug Metabolism and Disposition April 2015, 43 (4) 631-645; DOI: https://doi.org/10.1124/dmd.114.062265
Qi Joy Yang
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., L.S., H.T., H.H.S., E.C.Y.C., K.S.P.); School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China (L.S.); School of Pharmacy, Shihezi University, Shihezi, Xinjiang, P.R. China (H.T.); and Denmark Pharmaceutical University, Copenhagen, Denmark (H.H.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Luqin Si
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., L.S., H.T., H.H.S., E.C.Y.C., K.S.P.); School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China (L.S.); School of Pharmacy, Shihezi University, Shihezi, Xinjiang, P.R. China (H.T.); and Denmark Pharmaceutical University, Copenhagen, Denmark (H.H.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hui Tang
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., L.S., H.T., H.H.S., E.C.Y.C., K.S.P.); School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China (L.S.); School of Pharmacy, Shihezi University, Shihezi, Xinjiang, P.R. China (H.T.); and Denmark Pharmaceutical University, Copenhagen, Denmark (H.H.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Helle H. Sveigaard
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., L.S., H.T., H.H.S., E.C.Y.C., K.S.P.); School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China (L.S.); School of Pharmacy, Shihezi University, Shihezi, Xinjiang, P.R. China (H.T.); and Denmark Pharmaceutical University, Copenhagen, Denmark (H.H.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Edwin C. Y. Chow
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., L.S., H.T., H.H.S., E.C.Y.C., K.S.P.); School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China (L.S.); School of Pharmacy, Shihezi University, Shihezi, Xinjiang, P.R. China (H.T.); and Denmark Pharmaceutical University, Copenhagen, Denmark (H.H.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. Sandy Pang
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., L.S., H.T., H.H.S., E.C.Y.C., K.S.P.); School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China (L.S.); School of Pharmacy, Shihezi University, Shihezi, Xinjiang, P.R. China (H.T.); and Denmark Pharmaceutical University, Copenhagen, Denmark (H.H.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Article Information

vol. 43 no. 4 631-645
DOI 
https://doi.org/10.1124/dmd.114.062265
PubMed 
25650380

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 20, 2014
  • Accepted February 3, 2015
  • Published online March 3, 2015.

Article Versions

  • Earlier version (February 3, 2015 - 07:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Qi Joy Yang,
  2. Luqin Si 1 ,
  3. Hui Tang 2 ,
  4. Helle H. Sveigaard,
  5. Edwin C. Y. Chow, and
  6. K. Sandy Pang
  1. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., L.S., H.T., H.H.S., E.C.Y.C., K.S.P.); School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China (L.S.); School of Pharmacy, Shihezi University, Shihezi, Xinjiang, P.R. China (H.T.); and Denmark Pharmaceutical University, Copenhagen, Denmark (H.H.S.)
  1. Address correspondence to:
    Dr. K. Sandy Pang, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada M5S 3M2. E-mail: ks.pang{at}utoronto.ca
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to March 2023

AbstractFullPdf
Aug 201751512
Sep 201753310
Oct 201763719
Nov 2017217220
Dec 2017061515
Jan 2018956116
Feb 20181031720
Mar 20181423526
Apr 2018613811
May 20181015827
Jun 2018411422
Jul 201876126
Aug 201824617
Sep 201837326
Oct 2018610225
Nov 2018214820
Dec 2018312311
Jan 2019210524
Feb 20191010327
Mar 201944518
Apr 201923925
May 201925125
Jun 201942333
Jul 201944731
Aug 201977537
Oct 201924922
Nov 201941421
Dec 201903219
Jan 202062428
Feb 202023123
Mar 202005716
May 202004429
Jun 202041825
Jul 202023317
Aug 202012513
Sep 202083518
Oct 202034621
Nov 202073148
Dec 202022931
Jan 202152134
Feb 202132712
Mar 20214364
Apr 20213322
May 20217241
Jun 20211673
Jul 20212742
Aug 20212774
Sep 20213135
Oct 20213935
Nov 20212513
Dec 20213674
Jan 20224377
Feb 20222275
Mar 202223108
Apr 20222966
May 20223343
Jun 20222744
Jul 202241219
Aug 20222123
Sep 20221885
Oct 20222528
Nov 20223413
Dec 20221626
Jan 20235175
Feb 20231725
Mar 20233013

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 43 (4)
Drug Metabolism and Disposition
Vol. 43, Issue 4
1 Apr 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
PBPK Modeling to Unravel Nonlinear Pharmacokinetics of Verapamil to Estimate the Fractional Clearance for Verapamil N-Demethylation in the Recirculating Rat Liver Preparation
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Rapid CommunicationAccelerated Communication

Nonlinear Metabolite Kinetics of Verapamil

Qi Joy Yang, Luqin Si, Hui Tang, Helle H. Sveigaard, Edwin C. Y. Chow and K. Sandy Pang
Drug Metabolism and Disposition April 1, 2015, 43 (4) 631-645; DOI: https://doi.org/10.1124/dmd.114.062265

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Rapid CommunicationAccelerated Communication

Nonlinear Metabolite Kinetics of Verapamil

Qi Joy Yang, Luqin Si, Hui Tang, Helle H. Sveigaard, Edwin C. Y. Chow and K. Sandy Pang
Drug Metabolism and Disposition April 1, 2015, 43 (4) 631-645; DOI: https://doi.org/10.1124/dmd.114.062265
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Appendix A
    • Appendix B
    • Appendix C
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Use of CYP Transgenic Mouse Models
  • Production of Recombinant hsa-mir-27b
Show more Accelerated Communication

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics