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Drug Metabolism & Disposition

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Table of Contents

May 01, 2015; Volume 43,Issue 5

Minireview

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    The 2014 Bernard B. Brodie Award Lecture—Epoxide Hydrolases: Drug Metabolism to Therapeutics for Chronic Pain
    Sean D. Kodani and Bruce D. Hammock
    Drug Metabolism and Disposition May 2015, 43 (5) 788-802; DOI: https://doi.org/10.1124/dmd.115.063339

Short Communication

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    Suppression of Pulmonary CYP2A13 Expression by Carcinogen-Induced Lung Tumorigenesis in a CYP2A13-Humanized Mouse Model
    Zhihua Liu, Vandana Megaraj, Lei Li, Stewart Sell, Jing Hu and Xinxin Ding
    Drug Metabolism and Disposition May 2015, 43 (5) 698-702; DOI: https://doi.org/10.1124/dmd.115.063305

Articles

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    Metabolism of MRX-I, a Novel Antibacterial Oxazolidinone, in Humans: The Oxidative Ring Opening of 2,3-Dihydropyridin-4-One Catalyzed by Non-P450 Enzymes
    Jian Meng, Dafang Zhong, Liang Li, Zhengyu Yuan, Hong Yuan, Cen Xie, Jialan Zhou, Chen Li, Mikhail Fedorovich Gordeev, Jinqian Liu and Xiaoyan Chen
    Drug Metabolism and Disposition May 2015, 43 (5) 646-659; DOI: https://doi.org/10.1124/dmd.114.061747
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    Induction of Human UDP-Glucuronosyltransferase 2B7 Gene Expression by Cytotoxic Anticancer Drugs in Liver Cancer HepG2 Cells
    Dong Gui Hu, Peter I. Mackenzie, Lu Lu, Robyn Meech and Ross A. McKinnon
    Drug Metabolism and Disposition May 2015, 43 (5) 660-668; DOI: https://doi.org/10.1124/dmd.114.062380
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    Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions
    Weiwei Jia, Feifei Du, Xinwei Liu, Rongrong Jiang, Fang Xu, Junling Yang, Li Li, Fengqing Wang, Olajide E. Olaleye, Jiajia Dong and Chuan Li
    Drug Metabolism and Disposition May 2015, 43 (5) 669-678; DOI: https://doi.org/10.1124/dmd.114.062000
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    Systemic Exposure to and Disposition of Catechols Derived from Salvia miltiorrhiza Roots (Danshen) after Intravenous Dosing DanHong Injection in Human Subjects, Rats, and Dogs
    Meijuan Li, Fengqing Wang, Yühong Huang, Feifei Du, Chenchun Zhong, Olajide E. Olaleye, Weiwei Jia, Yanfen Li, Fang Xu, Jiajia Dong, Jian Li, Justin B. R. Lim, Buchang Zhao, Lifu Jia, Li Li and Chuan Li
    Drug Metabolism and Disposition May 2015, 43 (5) 679-690; DOI: https://doi.org/10.1124/dmd.114.061473
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    No Contribution of the ABCB11 p.444A Polymorphism in Japanese Patients with Drug-Induced Cholestasis
    Tatehiro Kagawa, Shunji Hirose, Yoshitaka Arase, Akira Oka, Kazuya Anzai, Kota Tsuruya, Koichi Shiraishi, Reiko Orii, Satsuki Ieda, Takahide Nakazawa, Kengo Tomita, Ryota Hokari, Soichiro Miura, Hirotoshi Ebinuma, Hidetsugu Saito, Tsuneo Kitamura, Yoshinori Horie, Chiaki Okuse, Mitsuru Wasada, Hidetoshi Inoko, Masahiro Tohkin, Yoshiro Saito, Keiko Maekawa, Hajime Takikawa and Tetsuya Mine
    Drug Metabolism and Disposition May 2015, 43 (5) 691-697; DOI: https://doi.org/10.1124/dmd.114.061325
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    CYP2A7 Pseudogene Transcript Affects CYP2A6 Expression in Human Liver by Acting as a Decoy for miR-126*
    Masataka Nakano, Yasunari Fukushima, Shin-ichi Yokota, Tatsuki Fukami, Masataka Takamiya, Yasuhiro Aoki, Tsuyoshi Yokoi and Miki Nakajima
    Drug Metabolism and Disposition May 2015, 43 (5) 703-712; DOI: https://doi.org/10.1124/dmd.115.063255
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    Guanfu Base A, an Antiarrhythmic Alkaloid of Aconitum coreanum, Is a CYP2D6 Inhibitor of Human, Monkey, and Dog Isoforms
    Jianguo Sun, Ying Peng, Hui Wu, Xueyuan Zhang, Yunxi Zhong, Yanan Xiao, Fengyi Zhang, Huanhuan Qi, Lili Shang, Jianping Zhu, Yue Sun, Ke Liu, Jinghan Liu, Jiye A, Rodney J. Y. Ho and Guangji Wang
    Drug Metabolism and Disposition May 2015, 43 (5) 713-724; DOI: https://doi.org/10.1124/dmd.114.060905
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    Toward Predicting Drug-Induced Liver Injury: Parallel Computational Approaches to Identify Multidrug Resistance Protein 4 and Bile Salt Export Pump Inhibitors
    Matthew A. Welch, Kathleen Köck, Thomas J. Urban, Kim L. R. Brouwer and Peter W. Swaan
    Drug Metabolism and Disposition May 2015, 43 (5) 725-734; DOI: https://doi.org/10.1124/dmd.114.062539
  • Activation and Deactivation of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine by Cytochrome P450 Enzymes and Flavin-Containing Monooxygenases in Common Marmosets (<em>Callithrix jacchus</em>)
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    Activation and Deactivation of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine by Cytochrome P450 Enzymes and Flavin-Containing Monooxygenases in Common Marmosets (Callithrix jacchus)
    Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Norie Murayama, Makiko Shimizu, Erika Sasaki and Hiroshi Yamazaki
    Drug Metabolism and Disposition May 2015, 43 (5) 735-742; DOI: https://doi.org/10.1124/dmd.115.063594
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    GW4064, an Agonist of Farnesoid X Receptor, Represses CYP3A4 Expression in Human Hepatocytes by Inducing Small Heterodimer Partner Expression
    Shu Zhang, Xian Pan and Hyunyoung Jeong
    Drug Metabolism and Disposition May 2015, 43 (5) 743-748; DOI: https://doi.org/10.1124/dmd.114.062836
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    Metabolism, Excretion, and Pharmacokinetics of S-Allyl-l-Cysteine in Rats and Dogs
    Hirotaka Amano, Daichi Kazamori, Kenji Itoh and Yukihiro Kodera
    Drug Metabolism and Disposition May 2015, 43 (5) 749-755; DOI: https://doi.org/10.1124/dmd.115.063230
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    In Vitro Characterization of the Bioconversion of Pomaglumetad Methionil, a Novel Metabotropic Glutamate 2/3 Receptor Agonist Peptide Prodrug
    Richard D. Moulton, Kenneth J. Ruterbories, David W. Bedwell and Michael A. Mohutsky
    Drug Metabolism and Disposition May 2015, 43 (5) 756-761; DOI: https://doi.org/10.1124/dmd.114.062893
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    Pharmacokinetics and Immunogenicity Investigation of a Human Anti-Interleukin-17 Monoclonal Antibody in Non-Naïve Cynomolgus Monkeys
    Chao Han, George R. Gunn, Joseph C. Marini, Gopi Shankar, Helen Han Hsu and Hugh M. Davis
    Drug Metabolism and Disposition May 2015, 43 (5) 762-770; DOI: https://doi.org/10.1124/dmd.114.062679
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    Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters
    Theresa V. Nguyen, Okechukwu Ukairo, Salman R. Khetani, Michael McVay, Chitra Kanchagar, Wolfgang Seghezzi, Gulesi Ayanoglu, Onyi Irrechukwu and Raymond Evers
    Drug Metabolism and Disposition May 2015, 43 (5) 774-785; DOI: https://doi.org/10.1124/dmd.114.061317

Letters to the Editor

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    Clinical Relevance of CYP3A5 Genotype on Maraviroc Exposures
    Manoli Vourvahis, Lynn McFadyen, Jayvant Heera and Andrew Clark
    Drug Metabolism and Disposition May 2015, 43 (5) 771-772; DOI: https://doi.org/10.1124/dmd.115.063321
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    Response to “Clinical Relevance of CYP3A5 Genotype on Maraviroc Exposures”
    Yanhui Lu, Edward J. Fuchs, Craig W. Hendrix and Namandjé N. Bumpus
    Drug Metabolism and Disposition May 2015, 43 (5) 773; DOI: https://doi.org/10.1124/dmd.115.064188

Erratum

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    Correction to: “Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions”
    Drug Metabolism and Disposition May 2015, 43 (5) 786-787; DOI: https://doi.org/10.1124/dmd.114.056309err
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Drug Metabolism and Disposition: 43 (5)
Drug Metabolism and Disposition
Vol. 43, Issue 5
1 May 2015
  • Table of Contents
  • Table of Contents (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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