Table of Contents

Articles

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  Metabolism of MRX-I, a Novel Antibacterial Oxazolidinone, in Humans: The Oxidative Ring Opening of 2,3-Dihydropyridin-4-One Catalyzed by Non-P450 Enzymes

  Jian Meng, Dafang Zhong, Liang Li, Zhengyu Yuan, Hong Yuan, Cen Xie, Jialan Zhou, Chen Li, Mikhail Fedorovich Gordeev, Jinqian Liu and Xiaoyan Chen

  Drug Metabolism and Disposition May 2015, 43 (5) 646-659; DOI: https://doi.org/10.1124/dmd.114.061747
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  Induction of Human UDP-Glucuronosyltransferase 2B7 Gene Expression by Cytotoxic Anticancer Drugs in Liver Cancer HepG2 Cells

  Dong Gui Hu, Peter I. Mackenzie, Lu Lu, Robyn Meech and Ross A. McKinnon

  Drug Metabolism and Disposition May 2015, 43 (5) 660-668; DOI: https://doi.org/10.1124/dmd.114.062380
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  Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions

  Weiwei Jia, Feifei Du, Xinwei Liu, Rongrong Jiang, Fang Xu, Junling Yang, Li Li, Fengqing Wang, Olajide E. Olaleye, Jiajia Dong and Chuan Li

  Drug Metabolism and Disposition May 2015, 43 (5) 669-678; DOI: https://doi.org/10.1124/dmd.114.062000
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  Systemic Exposure to and Disposition of Catechols Derived from Salvia miltiorrhiza Roots (Danshen) after Intravenous Dosing DanHong Injection in Human Subjects, Rats, and Dogs

  Meijuan Li, Fengqing Wang, Yühong Huang, Feifei Du, Chenchun Zhong, Olajide E. Olaleye, Weiwei Jia, Yanfen Li, Fang Xu, Jiajia Dong, Jian Li, Justin B. R. Lim, Buchang Zhao, Lifu Jia, Li Li and Chuan Li

  Drug Metabolism and Disposition May 2015, 43 (5) 679-690; DOI: https://doi.org/10.1124/dmd.114.061473
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  No Contribution of the ABCB11 p.444A Polymorphism in Japanese Patients with Drug-Induced Cholestasis

  Tatehiro Kagawa, Shunji Hirose, Yoshitaka Arase, Akira Oka, Kazuya Anzai, Kota Tsuruya, Koichi Shiraishi, Reiko Orii, Satsuki Ieda, Takahide Nakazawa, Kengo Tomita, Ryota Hokari, Soichiro Miura, Hirotoshi Ebinuma, Hidetsugu Saito, Tsuneo Kitamura, Yoshinori Horie, Chiaki Okuse, Mitsuru Wasada, Hidetoshi Inoko, Masahiro Tohkin, Yoshiro Saito, Keiko Maekawa, Hajime Takikawa and Tetsuya Mine

  Drug Metabolism and Disposition May 2015, 43 (5) 691-697; DOI: https://doi.org/10.1124/dmd.114.061325
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  CYP2A7 Pseudogene Transcript Affects CYP2A6 Expression in Human Liver by Acting as a Decoy for miR-126*

  Masataka Nakano, Yasunari Fukushima, Shin-ichi Yokota, Tatsuki Fukami, Masataka Takamiya, Yasuhiro Aoki, Tsuyoshi Yokoi and Miki Nakajima

  Drug Metabolism and Disposition May 2015, 43 (5) 703-712; DOI: https://doi.org/10.1124/dmd.115.063255
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  Guanfu Base A, an Antiarrhythmic Alkaloid of Aconitum coreanum, Is a CYP2D6 Inhibitor of Human, Monkey, and Dog Isoforms

  Jianguo Sun, Ying Peng, Hui Wu, Xueyuan Zhang, Yunxi Zhong, Yanan Xiao, Fengyi Zhang, Huanhuan Qi, Lili Shang, Jianping Zhu, Yue Sun, Ke Liu, Jinghan Liu, Jiye A, Rodney J. Y. Ho and Guangji Wang

  Drug Metabolism and Disposition May 2015, 43 (5) 713-724; DOI: https://doi.org/10.1124/dmd.114.060905
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  Toward Predicting Drug-Induced Liver Injury: Parallel Computational Approaches to Identify Multidrug Resistance Protein 4 and Bile Salt Export Pump Inhibitors

  Matthew A. Welch, Kathleen Köck, Thomas J. Urban, Kim L. R. Brouwer and Peter W. Swaan

  Drug Metabolism and Disposition May 2015, 43 (5) 725-734; DOI: https://doi.org/10.1124/dmd.114.062539
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  Activation and Deactivation of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine by Cytochrome P450 Enzymes and Flavin-Containing Monooxygenases in Common Marmosets (Callithrix jacchus)

  Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Norie Murayama, Makiko Shimizu, Erika Sasaki and Hiroshi Yamazaki

  Drug Metabolism and Disposition May 2015, 43 (5) 735-742; DOI: https://doi.org/10.1124/dmd.115.063594
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  GW4064, an Agonist of Farnesoid X Receptor, Represses CYP3A4 Expression in Human Hepatocytes by Inducing Small Heterodimer Partner Expression

  Shu Zhang, Xian Pan and Hyunyoung Jeong

  Drug Metabolism and Disposition May 2015, 43 (5) 743-748; DOI: https://doi.org/10.1124/dmd.114.062836
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  Metabolism, Excretion, and Pharmacokinetics of S-Allyl-l-Cysteine in Rats and Dogs

  Hirotaka Amano, Daichi Kazamori, Kenji Itoh and Yukihiro Kodera

  Drug Metabolism and Disposition May 2015, 43 (5) 749-755; DOI: https://doi.org/10.1124/dmd.115.063230
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  In Vitro Characterization of the Bioconversion of Pomaglumetad Methionil, a Novel Metabotropic Glutamate 2/3 Receptor Agonist Peptide Prodrug

  Richard D. Moulton, Kenneth J. Ruterbories, David W. Bedwell and Michael A. Mohutsky

  Drug Metabolism and Disposition May 2015, 43 (5) 756-761; DOI: https://doi.org/10.1124/dmd.114.062893
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  Pharmacokinetics and Immunogenicity Investigation of a Human Anti-Interleukin-17 Monoclonal Antibody in Non-Naïve Cynomolgus Monkeys

  Chao Han, George R. Gunn, Joseph C. Marini, Gopi Shankar, Helen Han Hsu and Hugh M. Davis

  Drug Metabolism and Disposition May 2015, 43 (5) 762-770; DOI: https://doi.org/10.1124/dmd.114.062679
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  Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters

  Theresa V. Nguyen, Okechukwu Ukairo, Salman R. Khetani, Michael McVay, Chitra Kanchagar, Wolfgang Seghezzi, Gulesi Ayanoglu, Onyi Irrechukwu and Raymond Evers

  Drug Metabolism and Disposition May 2015, 43 (5) 774-785; DOI: https://doi.org/10.1124/dmd.114.061317