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Research ArticleArticle

Metabolism of MRX-I, a Novel Antibacterial Oxazolidinone, in Humans: The Oxidative Ring Opening of 2,3-Dihydropyridin-4-One Catalyzed by Non-P450 Enzymes

Jian Meng, Dafang Zhong, Liang Li, Zhengyu Yuan, Hong Yuan, Cen Xie, Jialan Zhou, Chen Li, Mikhail Fedorovich Gordeev, Jinqian Liu and Xiaoyan Chen
Drug Metabolism and Disposition May 2015, 43 (5) 646-659; DOI: https://doi.org/10.1124/dmd.114.061747
Jian Meng
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Dafang Zhong
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Liang Li
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Zhengyu Yuan
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Hong Yuan
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Cen Xie
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Jialan Zhou
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Chen Li
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Mikhail Fedorovich Gordeev
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Jinqian Liu
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Xiaoyan Chen
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
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Article Information

vol. 43 no. 5 646-659
DOI 
https://doi.org/10.1124/dmd.114.061747
PubMed 
25710940

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 7, 2014
  • Accepted February 18, 2015
  • Published online March 23, 2015.

Article Versions

  • Earlier version (February 20, 2015 - 04:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jian Meng,
  2. Dafang Zhong,
  3. Liang Li,
  4. Zhengyu Yuan,
  5. Hong Yuan,
  6. Cen Xie,
  7. Jialan Zhou,
  8. Chen Li,
  9. Mikhail Fedorovich Gordeev,
  10. Jinqian Liu, and
  11. Xiaoyan Chen
  1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (J.M., D.Z., L.L., C.X., J.Z., C.L., X.C.); MicuRx Pharmaceuticals, Inc., Shanghai, China (Z.Y., H.Y.); and MicuRx Pharmaceuticals, Inc., Hayward, California (M.G., J.L.)
  1. Address correspondence to:
    Xiaoyan Chen, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, China. E-mail: xychen{at}simm.ac.cn
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Drug Metabolism and Disposition: 43 (5)
Drug Metabolism and Disposition
Vol. 43, Issue 5
1 May 2015
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Research ArticleArticle

Metabolism of Antibacterial Oxazolidinone MRX-I in Humans

Jian Meng, Dafang Zhong, Liang Li, Zhengyu Yuan, Hong Yuan, Cen Xie, Jialan Zhou, Chen Li, Mikhail Fedorovich Gordeev, Jinqian Liu and Xiaoyan Chen
Drug Metabolism and Disposition May 1, 2015, 43 (5) 646-659; DOI: https://doi.org/10.1124/dmd.114.061747

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Research ArticleArticle

Metabolism of Antibacterial Oxazolidinone MRX-I in Humans

Jian Meng, Dafang Zhong, Liang Li, Zhengyu Yuan, Hong Yuan, Cen Xie, Jialan Zhou, Chen Li, Mikhail Fedorovich Gordeev, Jinqian Liu and Xiaoyan Chen
Drug Metabolism and Disposition May 1, 2015, 43 (5) 646-659; DOI: https://doi.org/10.1124/dmd.114.061747
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