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Research ArticleArticle

Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions

Weiwei Jia, Feifei Du, Xinwei Liu, Rongrong Jiang, Fang Xu, Junling Yang, Li Li, Fengqing Wang, Olajide E. Olaleye, Jiajia Dong and Chuan Li
Drug Metabolism and Disposition May 2015, 43 (5) 669-678; DOI: https://doi.org/10.1124/dmd.114.062000
Weiwei Jia
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Feifei Du
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Xinwei Liu
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Rongrong Jiang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Fang Xu
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Junling Yang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Li Li
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Fengqing Wang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Olajide E. Olaleye
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Jiajia Dong
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Chuan Li
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Drug Metabolism and Disposition: 43 (5)
Drug Metabolism and Disposition
Vol. 43, Issue 5
1 May 2015
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Research ArticleArticle

Renal Tubular Secretion of Tanshinol

Weiwei Jia, Feifei Du, Xinwei Liu, Rongrong Jiang, Fang Xu, Junling Yang, Li Li, Fengqing Wang, Olajide E. Olaleye, Jiajia Dong and Chuan Li
Drug Metabolism and Disposition May 1, 2015, 43 (5) 669-678; DOI: https://doi.org/10.1124/dmd.114.062000

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Research ArticleArticle

Renal Tubular Secretion of Tanshinol

Weiwei Jia, Feifei Du, Xinwei Liu, Rongrong Jiang, Fang Xu, Junling Yang, Li Li, Fengqing Wang, Olajide E. Olaleye, Jiajia Dong and Chuan Li
Drug Metabolism and Disposition May 1, 2015, 43 (5) 669-678; DOI: https://doi.org/10.1124/dmd.114.062000
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