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Research ArticleArticle

Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions

Weiwei Jia, Feifei Du, Xinwei Liu, Rongrong Jiang, Fang Xu, Junling Yang, Li Li, Fengqing Wang, Olajide E. Olaleye, Jiajia Dong and Chuan Li
Drug Metabolism and Disposition May 2015, 43 (5) 669-678; DOI: https://doi.org/10.1124/dmd.114.062000
Weiwei Jia
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Feifei Du
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Xinwei Liu
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Rongrong Jiang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Fang Xu
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Junling Yang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Li Li
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Fengqing Wang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Olajide E. Olaleye
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Jiajia Dong
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Chuan Li
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
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Article Information

vol. 43 no. 5 669-678
DOI 
https://doi.org/10.1124/dmd.114.062000
PubMed 
25710938

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 7, 2014
  • Accepted February 20, 2015
  • Published online March 25, 2015.

Article Versions

  • Earlier version (February 20, 2015 - 10:14).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Weiwei Jia,
  2. Feifei Du,
  3. Xinwei Liu,
  4. Rongrong Jiang,
  5. Fang Xu,
  6. Junling Yang,
  7. Li Li,
  8. Fengqing Wang,
  9. Olajide E. Olaleye,
  10. Jiajia Dong, and
  11. Chuan Li
  1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai (W.J., F.D., X.L., R.J., F.X., J.Y., L.L., F.W., O.E.O., J.D., C.L.); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin (W.J.); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (C.L.), People’s Republic of China
  1. Address correspondence to:
    Dr. Chuan Li, Laboratory for DMPK Research of Herbal Medicines, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People’s Republic of China. E-mail: chli{at}simm.ac.cn
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Drug Metabolism and Disposition: 43 (5)
Drug Metabolism and Disposition
Vol. 43, Issue 5
1 May 2015
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Research ArticleArticle

Renal Tubular Secretion of Tanshinol

Weiwei Jia, Feifei Du, Xinwei Liu, Rongrong Jiang, Fang Xu, Junling Yang, Li Li, Fengqing Wang, Olajide E. Olaleye, Jiajia Dong and Chuan Li
Drug Metabolism and Disposition May 1, 2015, 43 (5) 669-678; DOI: https://doi.org/10.1124/dmd.114.062000

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Research ArticleArticle

Renal Tubular Secretion of Tanshinol

Weiwei Jia, Feifei Du, Xinwei Liu, Rongrong Jiang, Fang Xu, Junling Yang, Li Li, Fengqing Wang, Olajide E. Olaleye, Jiajia Dong and Chuan Li
Drug Metabolism and Disposition May 1, 2015, 43 (5) 669-678; DOI: https://doi.org/10.1124/dmd.114.062000
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