Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

Toward Predicting Drug-Induced Liver Injury: Parallel Computational Approaches to Identify Multidrug Resistance Protein 4 and Bile Salt Export Pump Inhibitors

Matthew A. Welch, Kathleen Köck, Thomas J. Urban, Kim L. R. Brouwer and Peter W. Swaan
Drug Metabolism and Disposition May 2015, 43 (5) 725-734; DOI: https://doi.org/10.1124/dmd.114.062539
Matthew A. Welch
Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (M.A.W., P.W.S.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.K., T.J.U., K.L.R.B.); Center for Human Genome Variation, Duke University Medical Center, Durham, North Carolina (T.J.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kathleen Köck
Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (M.A.W., P.W.S.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.K., T.J.U., K.L.R.B.); Center for Human Genome Variation, Duke University Medical Center, Durham, North Carolina (T.J.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas J. Urban
Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (M.A.W., P.W.S.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.K., T.J.U., K.L.R.B.); Center for Human Genome Variation, Duke University Medical Center, Durham, North Carolina (T.J.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kim L. R. Brouwer
Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (M.A.W., P.W.S.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.K., T.J.U., K.L.R.B.); Center for Human Genome Variation, Duke University Medical Center, Durham, North Carolina (T.J.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter W. Swaan
Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (M.A.W., P.W.S.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.K., T.J.U., K.L.R.B.); Center for Human Genome Variation, Duke University Medical Center, Durham, North Carolina (T.J.U.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Article Information

vol. 43 no. 5 725-734
DOI 
https://doi.org/10.1124/dmd.114.062539
PubMed 
25735837

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 26, 2015
  • Accepted February 27, 2015
  • Published online March 27, 2015.

Article Versions

  • Earlier version (March 3, 2015 - 08:53).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Matthew A. Welch,
  2. Kathleen Köck,
  3. Thomas J. Urban,
  4. Kim L. R. Brouwer, and
  5. Peter W. Swaan
  1. Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (M.A.W., P.W.S.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (K.K., T.J.U., K.L.R.B.); Center for Human Genome Variation, Duke University Medical Center, Durham, North Carolina (T.J.U.)
  1. Address correspondence to:
    Peter W. Swaan, Ph.D., Department of Pharmaceutical Sciences, University of Maryland, Baltimore MD 21201. E-mail pswaan{at}rx.umaryland.edu
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: March 2015 to January 2021

AbstractFullPdf
Mar 20156778278
Apr 20155272992
May 20152111843
Jun 20151181032
Jul 201598917
Aug 2015601424
Sep 201572821
Oct 2015361718
Nov 20152435
Dec 2015431520
Jan 2016571416
Feb 2016221418
Mar 201625816
Apr 2016373721
May 2016391317
Jun 2016401118
Jul 2016301221
Aug 2016411519
Sep 2016191814
Oct 201692320
Nov 201681817
Dec 201622911
Jan 20171253
Feb 20171235
Mar 201712526
Apr 201722416
May 201702422
Jun 20176207
Jul 201711411
Aug 201711310
Sep 2017420821
Oct 201731049
Nov 201722115
Dec 201751613
Jan 20183819
Feb 20181812
Mar 201851510
Apr 201842919
May 201822623
Jun 201832725
Jul 201811920
Aug 201862424
Sep 201813618
Oct 201831617
Nov 201851524
Dec 20186109
Jan 201931315
Feb 20196517
Mar 20194719
Apr 201941522
May 201942326
Jun 20191812
Jul 201911015
Aug 201941131
Sep 201992122
Oct 201931019
Nov 201911718
Dec 201972319
Jan 2020111224
Feb 202012416
Mar 202031720
Apr 20202186
May 202041211
Jun 202011111
Jul 202011126
Aug 20201458
Sep 202031018
Oct 202086822
Nov 202021726
Dec 20204919
Jan 202141211

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 43 (5)
Drug Metabolism and Disposition
Vol. 43, Issue 5
1 May 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Toward Predicting Drug-Induced Liver Injury: Parallel Computational Approaches to Identify Multidrug Resistance Protein 4 and Bile Salt Export Pump Inhibitors
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Computational Modeling of MRP4 and BSEP to Predict DILI

Matthew A. Welch, Kathleen Köck, Thomas J. Urban, Kim L. R. Brouwer and Peter W. Swaan
Drug Metabolism and Disposition May 1, 2015, 43 (5) 725-734; DOI: https://doi.org/10.1124/dmd.114.062539

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleArticle

Computational Modeling of MRP4 and BSEP to Predict DILI

Matthew A. Welch, Kathleen Köck, Thomas J. Urban, Kim L. R. Brouwer and Peter W. Swaan
Drug Metabolism and Disposition May 1, 2015, 43 (5) 725-734; DOI: https://doi.org/10.1124/dmd.114.062539
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Candesartan glucuronide serves as a CYP2C8 inhibitor
  • Role of AADAC on eslicarbazepine acetate hydrolysis
  • Gene expression profile of human intestinal epithelial cells
Show more Articles

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics