Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters

Theresa V. Nguyen, Okechukwu Ukairo, Salman R. Khetani, Michael McVay, Chitra Kanchagar, Wolfgang Seghezzi, Gulesi Ayanoglu, Onyi Irrechukwu and Raymond Evers
Drug Metabolism and Disposition May 2015, 43 (5) 774-785; DOI: https://doi.org/10.1124/dmd.114.061317
Theresa V. Nguyen
Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusetts (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, Massachusetts (C.K); and Merck Research Laboratories, Department of Bioanalytics, Palo Alto, California (W.S., G.A)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Okechukwu Ukairo
Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusetts (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, Massachusetts (C.K); and Merck Research Laboratories, Department of Bioanalytics, Palo Alto, California (W.S., G.A)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Salman R. Khetani
Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusetts (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, Massachusetts (C.K); and Merck Research Laboratories, Department of Bioanalytics, Palo Alto, California (W.S., G.A)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael McVay
Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusetts (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, Massachusetts (C.K); and Merck Research Laboratories, Department of Bioanalytics, Palo Alto, California (W.S., G.A)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chitra Kanchagar
Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusetts (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, Massachusetts (C.K); and Merck Research Laboratories, Department of Bioanalytics, Palo Alto, California (W.S., G.A)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wolfgang Seghezzi
Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusetts (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, Massachusetts (C.K); and Merck Research Laboratories, Department of Bioanalytics, Palo Alto, California (W.S., G.A)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gulesi Ayanoglu
Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusetts (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, Massachusetts (C.K); and Merck Research Laboratories, Department of Bioanalytics, Palo Alto, California (W.S., G.A)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Onyi Irrechukwu
Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusetts (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, Massachusetts (C.K); and Merck Research Laboratories, Department of Bioanalytics, Palo Alto, California (W.S., G.A)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raymond Evers
Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusetts (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, Massachusetts (C.K); and Merck Research Laboratories, Department of Bioanalytics, Palo Alto, California (W.S., G.A)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Article Information

vol. 43 no. 5 774-785
DOI 
https://doi.org/10.1124/dmd.114.061317
PubMed 
25739975

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 23, 2014
  • Accepted March 4, 2014
  • Published online April 1, 2015.

Article Versions

  • Earlier version (March 4, 2015 - 09:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Theresa V. Nguyen,
  2. Okechukwu Ukairo,
  3. Salman R. Khetani,
  4. Michael McVay,
  5. Chitra Kanchagar,
  6. Wolfgang Seghezzi,
  7. Gulesi Ayanoglu,
  8. Onyi Irrechukwu, and
  9. Raymond Evers
  1. Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusetts (M.M.); University Of Massachusetts Medical School, Department of Molecular Medicine, Worcester, Massachusetts (C.K); and Merck Research Laboratories, Department of Bioanalytics, Palo Alto, California (W.S., G.A)
  1. Address correspondence to:
    Dr. Theresa Nguyen, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Mailstop: RY800-B211, 126 Lincoln Ave, Rahway NJ 07065. E-mail: theresa.nguyen{at}merck.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: March 2015 to January 2021

AbstractFullPdf
Mar 20157452293
Apr 201561476179
May 20152292259
Jun 20151252329
Jul 20151131231
Aug 2015811729
Sep 2015591118
Oct 2015471721
Nov 2015422019
Dec 201547914
Jan 2016671936
Feb 2016411029
Mar 2016312220
Apr 2016413024
May 2016373734
Jun 2016433539
Jul 2016342433
Aug 2016402230
Sep 2016214226
Oct 2016186028
Nov 20161623741
Dec 20161017138
Jan 2017125434
Feb 201785029
Mar 2017185240
Apr 2017124839
May 2017263524
Jun 2017173622
Jul 2017103635
Aug 201773721
Sep 2017115342
Oct 2017137440
Nov 2017146449
Dec 2017114631
Jan 201875730
Feb 2018153130
Mar 2018214035
Apr 2018183628
May 2018204529
Jun 2018213129
Jul 2018132536
Aug 2018143150
Sep 201885437
Oct 2018105956
Nov 2018133545
Dec 201862033
Jan 201982649
Feb 2019194550
Mar 2019113054
Apr 2019164480
May 201984666
Jun 2019133662
Jul 201972459
Aug 2019149354
Sep 20191512946
Oct 2019146275
Nov 201975342
Dec 2019114339
Jan 2020133054
Feb 202054133
Mar 202074154
Apr 2020153869
May 202084879
Jun 202043346
Jul 202033932
Aug 202054242
Sep 202063541
Oct 202043635
Nov 202013234
Dec 202094045
Jan 202165137

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 43 (5)
Drug Metabolism and Disposition
Vol. 43, Issue 5
1 May 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Hepatocyte-Kupffer Cell Coculture for Studying Cytokine Effects

Theresa V. Nguyen, Okechukwu Ukairo, Salman R. Khetani, Michael McVay, Chitra Kanchagar, Wolfgang Seghezzi, Gulesi Ayanoglu, Onyi Irrechukwu and Raymond Evers
Drug Metabolism and Disposition May 1, 2015, 43 (5) 774-785; DOI: https://doi.org/10.1124/dmd.114.061317

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleArticle

Hepatocyte-Kupffer Cell Coculture for Studying Cytokine Effects

Theresa V. Nguyen, Okechukwu Ukairo, Salman R. Khetani, Michael McVay, Chitra Kanchagar, Wolfgang Seghezzi, Gulesi Ayanoglu, Onyi Irrechukwu and Raymond Evers
Drug Metabolism and Disposition May 1, 2015, 43 (5) 774-785; DOI: https://doi.org/10.1124/dmd.114.061317
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • IVIVE of Rosuvastatin Hepatic Clearance in Human
  • Simultaneous Determination of Brain Penetration and Systemic PK Parameters
  • Impact of Transport Direction on MATE1 Inhibition
Show more Articles

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics