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Drug Metabolism & Disposition

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Table of Contents

July 01, 2015; Volume 43,Issue 7

Announcement

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    ASPET Journals Support the National Institutes of Health Principles and Guidelines for Reporting Preclinical Research
    Drug Metabolism and Disposition July 2015, 43 (7) 1154-1155; DOI: https://doi.org/10.1124/dmd.115.065524

Short Communication

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    Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice
    Shuang Wang, Debbie Bott, Aveline Tung, Kim S. Sugamori and Denis M. Grant
    Drug Metabolism and Disposition July 2015, 43 (7) 916-921; DOI: https://doi.org/10.1124/dmd.115.063297

Articles

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    Characterization of the Canine Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 (cbr1) and the Functional Isoform cbr1 V218
    Daniel C. Ferguson, Qiuying Cheng and Javier G. Blanco
    Drug Metabolism and Disposition July 2015, 43 (7) 922-927; DOI: https://doi.org/10.1124/dmd.115.064295
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    Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10
    Jacqueline Ramírez, Snezana Mirkov, Larry K. House and Mark J. Ratain
    Drug Metabolism and Disposition July 2015, 43 (7) 928-935; DOI: https://doi.org/10.1124/dmd.115.063271
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    Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652
    Nathalie Rioux, Lorna H. Mitchell, Philip Tiller, Katie Plant, Joanne Shaw, Kerry Frost, Scott Ribich, Mikel P. Moyer, Robert A. Copeland, Richard Chesworth and Nigel J. Waters
    Drug Metabolism and Disposition July 2015, 43 (7) 936-943; DOI: https://doi.org/10.1124/dmd.115.064014
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    Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac
    Renato J. Scialis, Iván L. Csanaky, Michael J. Goedken and José E. Manautou
    Drug Metabolism and Disposition July 2015, 43 (7) 944-950; DOI: https://doi.org/10.1124/dmd.114.061705
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    Polyinosinic/Polycytidylic Acid–Mediated Changes in Maternal and Fetal Disposition of Lopinavir in Rats
    Vanja Petrovic and Micheline Piquette-Miller
    Drug Metabolism and Disposition July 2015, 43 (7) 951-957; DOI: https://doi.org/10.1124/dmd.114.062315
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    Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats
    Azumi Iida, Eita Sasaki, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition July 2015, 43 (7) 958-968; DOI: https://doi.org/10.1124/dmd.115.063370
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    Substrate Selectivities and Catalytic Activities of Marmoset Liver Cytochrome P450 2A6 Differed from Those of Human P450 2A6
    Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki and Hiroshi Yamazaki
    Drug Metabolism and Disposition July 2015, 43 (7) 969-976; DOI: https://doi.org/10.1124/dmd.115.063909
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    UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes
    Lijun Zhu, Linlin Lu, Shan Zeng, Feifei Luo, Peimin Dai, Peng Wu, Ying Wang, Liang Liu, Ming Hu and Zhongqiu Liu
    Drug Metabolism and Disposition July 2015, 43 (7) 977-983; DOI: https://doi.org/10.1124/dmd.115.063552
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    Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression
    Hong Shen, Tongtong Liu, Bridget L. Morse, Yue Zhao, Yueping Zhang, Xi Qiu, Cliff Chen, Anne C. Lewin, Xi-Tao Wang, Guowen Liu, Lisa J. Christopher, Punit Marathe and Yurong Lai
    Drug Metabolism and Disposition July 2015, 43 (7) 984-993; DOI: https://doi.org/10.1124/dmd.114.062364
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    Differences in Methadone Metabolism by CYP2B6 Variants
    Sarah Gadel, Christina Friedel and Evan D. Kharasch
    Drug Metabolism and Disposition July 2015, 43 (7) 994-1001; DOI: https://doi.org/10.1124/dmd.115.064352
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    Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner
    Xian Pan, Yoon-Kwang Lee and Hyunyoung Jeong
    Drug Metabolism and Disposition July 2015, 43 (7) 1002-1007; DOI: https://doi.org/10.1124/dmd.115.064758
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    Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2– Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration
    Houfu Liu, Na Yu, Sijie Lu, Sumito Ito, Xuan Zhang, Bhagwat Prasad, Enuo He, Xinyan Lu, Yang Li, Fei Wang, Han Xu, Gang An, Jashvant D. Unadkat, Hiroyuki Kusuhara, Yuichi Sugiyama and Jasminder Sahi
    Drug Metabolism and Disposition July 2015, 43 (7) 1008-1018; DOI: https://doi.org/10.1124/dmd.115.064170
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    Metabolism of Bupropion by Carbonyl Reductases in Liver and Intestine
    Jamie N. Connarn, Xinyuan Zhang, Andrew Babiskin and Duxin Sun
    Drug Metabolism and Disposition July 2015, 43 (7) 1019-1027; DOI: https://doi.org/10.1124/dmd.115.063107
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    Hepatoselective Nitric Oxide (NO) Donors, V-PYRRO/NO and V-PROLI/NO, in Nonalcoholic Fatty Liver Disease: A Comparison of Antisteatotic Effects with the Biotransformation and Pharmacokinetics
    Kamil Kus, Maria Walczak, Edyta Maslak, Agnieszka Zakrzewska, Anna Gonciarz-Dytman, Piotr Zabielski, Barbara Sitek, Krystyna Wandzel, Agnieszka Kij, Adrian Chabowski, Ryan J. Holland, Joseph E. Saavedra, Larry K. Keefer and Stefan Chlopicki
    Drug Metabolism and Disposition July 2015, 43 (7) 1028-1036; DOI: https://doi.org/10.1124/dmd.115.063388
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    Activity Suppression Behavior Phenotype in SULT4A1 Frameshift Mutant Zebrafish
    Frank Crittenden, Holly R. Thomas, John M. Parant and Charles N. Falany
    Drug Metabolism and Disposition July 2015, 43 (7) 1037-1044; DOI: https://doi.org/10.1124/dmd.115.064485
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    Ethnic Variability in the Expression of Hepatic Drug Transporters: Absolute Quantification by an Optimized Targeted Quantitative Proteomic Approach
    Kuan-wei Peng, James Bacon, Ming Zheng, Yingying Guo and Michael Zhuo Wang
    Drug Metabolism and Disposition July 2015, 43 (7) 1045-1055; DOI: https://doi.org/10.1124/dmd.115.063362
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    Upregulation of UGT2B4 Expression by 3′-Phosphoadenosine-5′-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation
    Kathleen G. Barrett, Hailin Fang, Daniela Cukovic, Alan A. Dombkowski, Thomas A. Kocarek and Melissa Runge-Morris
    Drug Metabolism and Disposition July 2015, 43 (7) 1061-1070; DOI: https://doi.org/10.1124/dmd.114.061440
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    Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain
    Yuki Kutsuno, Rika Hirashima, Masaya Sakamoto, Hiroko Ushikubo, Hirofumi Michimae, Tomoo Itoh, Robert H. Tukey and Ryoichi Fujiwara
    Drug Metabolism and Disposition July 2015, 43 (7) 1071-1076; DOI: https://doi.org/10.1124/dmd.115.063719
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    Pharmacokinetics and Pharmacodynamics of the SGLT2 Inhibitor Remogliflozin Etabonate in Subjects with Mild and Moderate Renal Impairment
    Robin O’Connor-Semmes, Susan Walker, Anita Kapur, Elizabeth K. Hussey, June Ye, Laurene Wang-Smith, Wenli Tao, Robert L. Dobbins, Bentley Cheatham and William O. Wilkison
    Drug Metabolism and Disposition July 2015, 43 (7) 1077-1083; DOI: https://doi.org/10.1124/dmd.114.062828
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    Hydroxylation and N-Dechloroethylation of Ifosfamide and Deuterated Ifosfamide by the Human Cytochrome P450s and Their Commonly Occurring Polymorphisms
    Diane M. Calinski, Haoming Zhang, Susan Ludeman, M. Eileen Dolan and Paul F. Hollenberg
    Drug Metabolism and Disposition July 2015, 43 (7) 1084-1090; DOI: https://doi.org/10.1124/dmd.115.063628
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    Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor
    Ujjal Sarkar, Dinelia Rivera-Burgos, Emma M. Large, David J. Hughes, Kodihalli C. Ravindra, Rachel L. Dyer, Mohammad R. Ebrahimkhani, John S. Wishnok, Linda G. Griffith and Steven R. Tannenbaum
    Drug Metabolism and Disposition July 2015, 43 (7) 1091-1099; DOI: https://doi.org/10.1124/dmd.115.063495
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    The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition
    Sheng-Nan Lo, Chien-Chang Shen, Chia-Yu Chang, Keng-Chang Tsai, Chiung-Chiao Huang, Tian-Shung Wu and Yune-Fang Ueng
    Drug Metabolism and Disposition July 2015, 43 (7) 1100-1107; DOI: https://doi.org/10.1124/dmd.115.063966
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    Quantitative Rationalization of Gemfibrozil Drug Interactions: Consideration of Transporters-Enzyme Interplay and the Role of Circulating Metabolite Gemfibrozil 1-O-β-Glucuronide
    Manthena V. S. Varma, Jian Lin, Yi-an Bi, Emi Kimoto and A. David Rodrigues
    Drug Metabolism and Disposition July 2015, 43 (7) 1108-1118; DOI: https://doi.org/10.1124/dmd.115.064303
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    Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase
    Shinya Hosaka, Norie Murayama, Masahiro Satsukawa, Shotaro Uehara, Makiko Shimizu, Kazuhide Iwasaki, Shunsuke Iwano, Yasuhiro Uno and Hiroshi Yamazaki
    Drug Metabolism and Disposition July 2015, 43 (7) 1119-1122; DOI: https://doi.org/10.1124/dmd.115.063925
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    Use of Cassette Dosing to Enhance the Throughput of Rat Brain Microdialysis Studies
    Gauri Deshmukh, Kefeng Sun, Bianca M. Liederer, Xiao Ding and Xingrong Liu
    Drug Metabolism and Disposition July 2015, 43 (7) 1123-1128; DOI: https://doi.org/10.1124/dmd.115.064204
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    Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity
    Mei-Mei Li, Balasubrahmanyam Addepalli, Mei-Juan Tu, Qiu-Xia Chen, Wei-Peng Wang, Patrick A. Limbach, Janine M. LaSalle, Su Zeng, Min Huang and Ai-Ming Yu
    Drug Metabolism and Disposition July 2015, 43 (7) 1129-1136; DOI: https://doi.org/10.1124/dmd.115.064493
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    Simultaneous Screening of Activities of Five Cytochrome P450 and Four Uridine 5′-Diphospho-glucuronosyltransferase Enzymes in Human Liver Microsomes Using Cocktail Incubation and Liquid Chromatography–Tandem Mass Spectrometry
    Boram Lee, Hyeon-Kyeong Ji, Taeho Lee and Kwang-Hyeon Liu
    Drug Metabolism and Disposition July 2015, 43 (7) 1137-1146; DOI: https://doi.org/10.1124/dmd.114.063016
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    Peony-Glycyrrhiza Decoction, an Herbal Preparation, Inhibits Clozapine Metabolism via Cytochrome P450s, but Not Flavin-Containing Monooxygenase in In Vitro Models
    Wei Wang, Dan-Dan Tian, Bin Zheng, Di Wang, Qing-Rong Tan, Chuan-Yue Wang and Zhang-Jin Zhang
    Drug Metabolism and Disposition July 2015, 43 (7) 1147-1153; DOI: https://doi.org/10.1124/dmd.114.062653

Letters to the Editor

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    Fractional Clearance for Verapamil N-Demethylation in the Isolated Rat Liver Preparation
    Reza Mehvar
    Drug Metabolism and Disposition July 2015, 43 (7) 1056-1057; DOI: https://doi.org/10.1124/dmd.115.064691
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    Response to Letter to the Editor on “Fractional Clearance for Verapamil N-Demethylation in the Isolated Rat Liver Preparation”
    K. Sandy Pang and Qi Joy Yang
    Drug Metabolism and Disposition July 2015, 43 (7) 1058-1059; DOI: https://doi.org/10.1124/dmd.115.065227

Erratum

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    Correction to: “PBPK Modeling to Unravel Nonlinear Pharmacokinetics of Verapamil to Estimate the Fractional Clearance for Verapamil N-Demethylation in the Recirculating Rat Liver Preparation”
    Drug Metabolism and Disposition July 2015, 43 (7) 1060; DOI: https://doi.org/10.1124/dmd.114.062265err
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Drug Metabolism and Disposition: 43 (7)
Drug Metabolism and Disposition
Vol. 43, Issue 7
1 Jul 2015
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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