Table of Contents

Articles

• You have access

  Characterization of the Canine Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 (cbr1) and the Functional Isoform cbr1 V218

  Daniel C. Ferguson, Qiuying Cheng and Javier G. Blanco

  Drug Metabolism and Disposition July 2015, 43 (7) 922-927; DOI: https://doi.org/10.1124/dmd.115.064295
• You have access

  Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10

  Jacqueline Ramírez, Snezana Mirkov, Larry K. House and Mark J. Ratain

  Drug Metabolism and Disposition July 2015, 43 (7) 928-935; DOI: https://doi.org/10.1124/dmd.115.063271
• You have access

  Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652

  Nathalie Rioux, Lorna H. Mitchell, Philip Tiller, Katie Plant, Joanne Shaw, Kerry Frost, Scott Ribich, Mikel P. Moyer, Robert A. Copeland, Richard Chesworth and Nigel J. Waters

  Drug Metabolism and Disposition July 2015, 43 (7) 936-943; DOI: https://doi.org/10.1124/dmd.115.064014
• You have access

  Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac

  Renato J. Scialis, Iván L. Csanaky, Michael J. Goedken and José E. Manautou

  Drug Metabolism and Disposition July 2015, 43 (7) 944-950; DOI: https://doi.org/10.1124/dmd.114.061705
• You have access

  Polyinosinic/Polycytidylic Acid–Mediated Changes in Maternal and Fetal Disposition of Lopinavir in Rats

  Vanja Petrovic and Micheline Piquette-Miller

  Drug Metabolism and Disposition July 2015, 43 (7) 951-957; DOI: https://doi.org/10.1124/dmd.114.062315
• You have access

  Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats

  Azumi Iida, Eita Sasaki, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition July 2015, 43 (7) 958-968; DOI: https://doi.org/10.1124/dmd.115.063370
• You have access

  Substrate Selectivities and Catalytic Activities of Marmoset Liver Cytochrome P450 2A6 Differed from Those of Human P450 2A6

  Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki and Hiroshi Yamazaki

  Drug Metabolism and Disposition July 2015, 43 (7) 969-976; DOI: https://doi.org/10.1124/dmd.115.063909
• You have access

  UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes

  Lijun Zhu, Linlin Lu, Shan Zeng, Feifei Luo, Peimin Dai, Peng Wu, Ying Wang, Liang Liu, Ming Hu and Zhongqiu Liu

  Drug Metabolism and Disposition July 2015, 43 (7) 977-983; DOI: https://doi.org/10.1124/dmd.115.063552
• You have access

  Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression

  Hong Shen, Tongtong Liu, Bridget L. Morse, Yue Zhao, Yueping Zhang, Xi Qiu, Cliff Chen, Anne C. Lewin, Xi-Tao Wang, Guowen Liu, Lisa J. Christopher, Punit Marathe and Yurong Lai

  Drug Metabolism and Disposition July 2015, 43 (7) 984-993; DOI: https://doi.org/10.1124/dmd.114.062364
• You have access

  Differences in Methadone Metabolism by CYP2B6 Variants

  Sarah Gadel, Christina Friedel and Evan D. Kharasch

  Drug Metabolism and Disposition July 2015, 43 (7) 994-1001; DOI: https://doi.org/10.1124/dmd.115.064352
• You have access

  Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner

  Xian Pan, Yoon-Kwang Lee and Hyunyoung Jeong

  Drug Metabolism and Disposition July 2015, 43 (7) 1002-1007; DOI: https://doi.org/10.1124/dmd.115.064758
• You have access

  Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2– Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration

  Houfu Liu, Na Yu, Sijie Lu, Sumito Ito, Xuan Zhang, Bhagwat Prasad, Enuo He, Xinyan Lu, Yang Li, Fei Wang, Han Xu, Gang An, Jashvant D. Unadkat, Hiroyuki Kusuhara, Yuichi Sugiyama and Jasminder Sahi

  Drug Metabolism and Disposition July 2015, 43 (7) 1008-1018; DOI: https://doi.org/10.1124/dmd.115.064170
• You have access

  Metabolism of Bupropion by Carbonyl Reductases in Liver and Intestine

  Jamie N. Connarn, Xinyuan Zhang, Andrew Babiskin and Duxin Sun

  Drug Metabolism and Disposition July 2015, 43 (7) 1019-1027; DOI: https://doi.org/10.1124/dmd.115.063107
• You have access

  Hepatoselective Nitric Oxide (NO) Donors, V-PYRRO/NO and V-PROLI/NO, in Nonalcoholic Fatty Liver Disease: A Comparison of Antisteatotic Effects with the Biotransformation and Pharmacokinetics

  Kamil Kus, Maria Walczak, Edyta Maslak, Agnieszka Zakrzewska, Anna Gonciarz-Dytman, Piotr Zabielski, Barbara Sitek, Krystyna Wandzel, Agnieszka Kij, Adrian Chabowski, Ryan J. Holland, Joseph E. Saavedra, Larry K. Keefer and Stefan Chlopicki

  Drug Metabolism and Disposition July 2015, 43 (7) 1028-1036; DOI: https://doi.org/10.1124/dmd.115.063388
• You have access

  Activity Suppression Behavior Phenotype in SULT4A1 Frameshift Mutant Zebrafish

  Frank Crittenden, Holly R. Thomas, John M. Parant and Charles N. Falany

  Drug Metabolism and Disposition July 2015, 43 (7) 1037-1044; DOI: https://doi.org/10.1124/dmd.115.064485
• You have access

  Ethnic Variability in the Expression of Hepatic Drug Transporters: Absolute Quantification by an Optimized Targeted Quantitative Proteomic Approach

  Kuan-wei Peng, James Bacon, Ming Zheng, Yingying Guo and Michael Zhuo Wang

  Drug Metabolism and Disposition July 2015, 43 (7) 1045-1055; DOI: https://doi.org/10.1124/dmd.115.063362
• You have access

  Upregulation of UGT2B4 Expression by 3′-Phosphoadenosine-5′-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation

  Kathleen G. Barrett, Hailin Fang, Daniela Cukovic, Alan A. Dombkowski, Thomas A. Kocarek and Melissa Runge-Morris

  Drug Metabolism and Disposition July 2015, 43 (7) 1061-1070; DOI: https://doi.org/10.1124/dmd.114.061440
• You have access

  Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain

  Yuki Kutsuno, Rika Hirashima, Masaya Sakamoto, Hiroko Ushikubo, Hirofumi Michimae, Tomoo Itoh, Robert H. Tukey and Ryoichi Fujiwara

  Drug Metabolism and Disposition July 2015, 43 (7) 1071-1076; DOI: https://doi.org/10.1124/dmd.115.063719
• You have access

  Pharmacokinetics and Pharmacodynamics of the SGLT2 Inhibitor Remogliflozin Etabonate in Subjects with Mild and Moderate Renal Impairment

  Robin O’Connor-Semmes, Susan Walker, Anita Kapur, Elizabeth K. Hussey, June Ye, Laurene Wang-Smith, Wenli Tao, Robert L. Dobbins, Bentley Cheatham and William O. Wilkison

  Drug Metabolism and Disposition July 2015, 43 (7) 1077-1083; DOI: https://doi.org/10.1124/dmd.114.062828
• You have access

  Hydroxylation and N-Dechloroethylation of Ifosfamide and Deuterated Ifosfamide by the Human Cytochrome P450s and Their Commonly Occurring Polymorphisms

  Diane M. Calinski, Haoming Zhang, Susan Ludeman, M. Eileen Dolan and Paul F. Hollenberg

  Drug Metabolism and Disposition July 2015, 43 (7) 1084-1090; DOI: https://doi.org/10.1124/dmd.115.063628
• You have access

  Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor

  Ujjal Sarkar, Dinelia Rivera-Burgos, Emma M. Large, David J. Hughes, Kodihalli C. Ravindra, Rachel L. Dyer, Mohammad R. Ebrahimkhani, John S. Wishnok, Linda G. Griffith and Steven R. Tannenbaum

  Drug Metabolism and Disposition July 2015, 43 (7) 1091-1099; DOI: https://doi.org/10.1124/dmd.115.063495
• You have access

  The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition

  Sheng-Nan Lo, Chien-Chang Shen, Chia-Yu Chang, Keng-Chang Tsai, Chiung-Chiao Huang, Tian-Shung Wu and Yune-Fang Ueng

  Drug Metabolism and Disposition July 2015, 43 (7) 1100-1107; DOI: https://doi.org/10.1124/dmd.115.063966
• You have access

  Quantitative Rationalization of Gemfibrozil Drug Interactions: Consideration of Transporters-Enzyme Interplay and the Role of Circulating Metabolite Gemfibrozil 1-O-β-Glucuronide

  Manthena V. S. Varma, Jian Lin, Yi-an Bi, Emi Kimoto and A. David Rodrigues

  Drug Metabolism and Disposition July 2015, 43 (7) 1108-1118; DOI: https://doi.org/10.1124/dmd.115.064303
• You have access

  Comprehensive Evaluation for Substrate Selectivity of Cynomolgus Monkey Cytochrome P450 2C9, a New Efavirenz Oxidase

  Shinya Hosaka, Norie Murayama, Masahiro Satsukawa, Shotaro Uehara, Makiko Shimizu, Kazuhide Iwasaki, Shunsuke Iwano, Yasuhiro Uno and Hiroshi Yamazaki

  Drug Metabolism and Disposition July 2015, 43 (7) 1119-1122; DOI: https://doi.org/10.1124/dmd.115.063925
• You have access

  Use of Cassette Dosing to Enhance the Throughput of Rat Brain Microdialysis Studies

  Gauri Deshmukh, Kefeng Sun, Bianca M. Liederer, Xiao Ding and Xingrong Liu

  Drug Metabolism and Disposition July 2015, 43 (7) 1123-1128; DOI: https://doi.org/10.1124/dmd.115.064204
• You have access

  Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity

  Mei-Mei Li, Balasubrahmanyam Addepalli, Mei-Juan Tu, Qiu-Xia Chen, Wei-Peng Wang, Patrick A. Limbach, Janine M. LaSalle, Su Zeng, Min Huang and Ai-Ming Yu

  Drug Metabolism and Disposition July 2015, 43 (7) 1129-1136; DOI: https://doi.org/10.1124/dmd.115.064493
• You have access

  Simultaneous Screening of Activities of Five Cytochrome P450 and Four Uridine 5′-Diphospho-glucuronosyltransferase Enzymes in Human Liver Microsomes Using Cocktail Incubation and Liquid Chromatography–Tandem Mass Spectrometry

  Boram Lee, Hyeon-Kyeong Ji, Taeho Lee and Kwang-Hyeon Liu

  Drug Metabolism and Disposition July 2015, 43 (7) 1137-1146; DOI: https://doi.org/10.1124/dmd.114.063016
• You have access

  Peony-Glycyrrhiza Decoction, an Herbal Preparation, Inhibits Clozapine Metabolism via Cytochrome P450s, but Not Flavin-Containing Monooxygenase in In Vitro Models

  Wei Wang, Dan-Dan Tian, Bin Zheng, Di Wang, Qing-Rong Tan, Chuan-Yue Wang and Zhang-Jin Zhang

  Drug Metabolism and Disposition July 2015, 43 (7) 1147-1153; DOI: https://doi.org/10.1124/dmd.114.062653