Department of Pharmaceutics (Y.K., R.H., M.S., T.I., R.F.), Department of Molecular Pharmacology (H.U.), and Division of Biostatistics (H.M.), School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan; and Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (R.H.T.)

Department of Pharmaceutics (Y.K., R.H., M.S., T.I., R.F.), Department of Molecular Pharmacology (H.U.), and Division of Biostatistics (H.M.), School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan; and Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (R.H.T.)

Department of Pharmaceutics (Y.K., R.H., M.S., T.I., R.F.), Department of Molecular Pharmacology (H.U.), and Division of Biostatistics (H.M.), School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan; and Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (R.H.T.)

Department of Pharmaceutics (Y.K., R.H., M.S., T.I., R.F.), Department of Molecular Pharmacology (H.U.), and Division of Biostatistics (H.M.), School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan; and Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (R.H.T.)

Department of Pharmaceutics (Y.K., R.H., M.S., T.I., R.F.), Department of Molecular Pharmacology (H.U.), and Division of Biostatistics (H.M.), School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan; and Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (R.H.T.)

Department of Pharmaceutics (Y.K., R.H., M.S., T.I., R.F.), Department of Molecular Pharmacology (H.U.), and Division of Biostatistics (H.M.), School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan; and Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (R.H.T.)

Department of Pharmaceutics (Y.K., R.H., M.S., T.I., R.F.), Department of Molecular Pharmacology (H.U.), and Division of Biostatistics (H.M.), School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan; and Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (R.H.T.)

Department of Pharmaceutics (Y.K., R.H., M.S., T.I., R.F.), Department of Molecular Pharmacology (H.U.), and Division of Biostatistics (H.M.), School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan; and Laboratory of Environmental Toxicology, Department of Pharmacology, University of California San Diego, La Jolla, California (R.H.T.)