Research ArticleArticle
Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor
Ujjal Sarkar, Dinelia Rivera-Burgos, Emma M. Large, David J. Hughes, Kodihalli C. Ravindra, Rachel L. Dyer, Mohammad R. Ebrahimkhani, John S. Wishnok, Linda G. Griffith and Steven R. Tannenbaum
Drug Metabolism and Disposition July 2015, 43 (7) 1091-1099; DOI: https://doi.org/10.1124/dmd.115.063495
Ujjal Sarkar
Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)
Dinelia Rivera-Burgos
Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)
Emma M. Large
Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)
David J. Hughes
Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)
Kodihalli C. Ravindra
Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)
Rachel L. Dyer
Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)
Mohammad R. Ebrahimkhani
Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)
John S. Wishnok
Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)
Linda G. Griffith
Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)
Steven R. Tannenbaum
Department of Biological Engineering (U.S., D.R.-B., K.C.R., R.L.D., M.R.E., J.S.W., L.G.G., S.R.T.), Department of Chemistry (S.R.T.), and Department of Mechanical Engineering (L.G.G.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and CN Bio Innovations, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom (E.M.L., D.J.H.)
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Research ArticleArticle
Hydrocortisone Metabolism in a 3D Bioreactor
Ujjal Sarkar, Dinelia Rivera-Burgos, Emma M. Large, David J. Hughes, Kodihalli C. Ravindra, Rachel L. Dyer, Mohammad R. Ebrahimkhani, John S. Wishnok, Linda G. Griffith and Steven R. Tannenbaum
Drug Metabolism and Disposition July 1, 2015, 43 (7) 1091-1099; DOI: https://doi.org/10.1124/dmd.115.063495
Research ArticleArticle
Hydrocortisone Metabolism in a 3D Bioreactor
Ujjal Sarkar, Dinelia Rivera-Burgos, Emma M. Large, David J. Hughes, Kodihalli C. Ravindra, Rachel L. Dyer, Mohammad R. Ebrahimkhani, John S. Wishnok, Linda G. Griffith and Steven R. Tannenbaum
Drug Metabolism and Disposition July 1, 2015, 43 (7) 1091-1099; DOI: https://doi.org/10.1124/dmd.115.063495
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