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Research ArticleArticle

Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats

Azumi Iida, Eita Sasaki, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi
Drug Metabolism and Disposition July 2015, 43 (7) 958-968; DOI: https://doi.org/10.1124/dmd.115.063370
Azumi Iida
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
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Eita Sasaki
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
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Azusa Yano
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
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Koichi Tsuneyama
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
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Tatsuki Fukami
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
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Miki Nakajima
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
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Tsuyoshi Yokoi
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
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Article Information

vol. 43 no. 7 958-968
DOI 
https://doi.org/10.1124/dmd.115.063370
PubMed 
25870103

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 16, 2015
  • Accepted April 13, 2015
  • Published online May 16, 2015.

Article Versions

  • Earlier version (April 13, 2015 - 08:16).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Azumi Iida,
  2. Eita Sasaki,
  3. Azusa Yano,
  4. Koichi Tsuneyama,
  5. Tatsuki Fukami,
  6. Miki Nakajima, and
  7. Tsuyoshi Yokoi
  1. Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
  1. Address correspondence to:
    Dr. Tsuyoshi Yokoi, Department of Drug Safety Science, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. E-mail: tyokoi{at}med.nagoya-u.ac.jp
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Drug Metabolism and Disposition: 43 (7)
Drug Metabolism and Disposition
Vol. 43, Issue 7
1 Jul 2015
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Research ArticleArticle

Hepatotoxicity by Carbamazepine Requires Metabolism in Rats

Azumi Iida, Eita Sasaki, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi
Drug Metabolism and Disposition July 1, 2015, 43 (7) 958-968; DOI: https://doi.org/10.1124/dmd.115.063370

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Research ArticleArticle

Hepatotoxicity by Carbamazepine Requires Metabolism in Rats

Azumi Iida, Eita Sasaki, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi
Drug Metabolism and Disposition July 1, 2015, 43 (7) 958-968; DOI: https://doi.org/10.1124/dmd.115.063370
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