Research ArticleArticle
Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats
Azumi Iida, Eita Sasaki, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi
Drug Metabolism and Disposition July 2015, 43 (7) 958-968; DOI: https://doi.org/10.1124/dmd.115.063370
Azumi Iida
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
Eita Sasaki
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
Azusa Yano
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
Koichi Tsuneyama
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
Tatsuki Fukami
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
Miki Nakajima
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)
Tsuyoshi Yokoi
Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (A.I., E.S., A.Y., T.F., M.N., T.Y.); Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan (K.T.); and Department of Drug Safety Science, Nagoya University Graduate School of Medicine, Nagoya, Japan (T.Y.)

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Research ArticleArticle
Hepatotoxicity by Carbamazepine Requires Metabolism in Rats
Azumi Iida, Eita Sasaki, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima and Tsuyoshi Yokoi
Drug Metabolism and Disposition July 1, 2015, 43 (7) 958-968; DOI: https://doi.org/10.1124/dmd.115.063370
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