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Research ArticleArticle

Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression

Hong Shen, Tongtong Liu, Bridget L. Morse, Yue Zhao, Yueping Zhang, Xi Qiu, Cliff Chen, Anne C. Lewin, Xi-Tao Wang, Guowen Liu, Lisa J. Christopher, Punit Marathe and Yurong Lai
Drug Metabolism and Disposition July 2015, 43 (7) 984-993; DOI: https://doi.org/10.1124/dmd.114.062364
Hong Shen
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Tongtong Liu
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Bridget L. Morse
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Yue Zhao
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Yueping Zhang
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Xi Qiu
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Cliff Chen
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Anne C. Lewin
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Xi-Tao Wang
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Guowen Liu
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Lisa J. Christopher
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Punit Marathe
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Yurong Lai
Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
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Article Information

vol. 43 no. 7 984-993
DOI 
https://doi.org/10.1124/dmd.114.062364
PubMed 
25904762

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 22, 2014
  • Accepted April 22, 2015
  • Published online May 18, 2015.

Article Versions

  • Earlier version (April 22, 2015 - 08:25).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hong Shen,
  2. Tongtong Liu,
  3. Bridget L. Morse,
  4. Yue Zhao,
  5. Yueping Zhang,
  6. Xi Qiu,
  7. Cliff Chen,
  8. Anne C. Lewin,
  9. Xi-Tao Wang,
  10. Guowen Liu,
  11. Lisa J. Christopher,
  12. Punit Marathe, and
  13. Yurong Lai
  1. Departments of Metabolism and Pharmacokinetics (H.S., T.L., B.L.M., Yuep.Z., X.Q., C.C., P.M., Y.L.), Bioanalytical Sciences (Y.Z., G.L.), Oncology Translational Research (A.C.L., X.-T.W.), and Biotransformation (L.J.C.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
  1. Address correspondence to:
    Dr. Hong Shen, Room F1.3802, Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08543-4000. E-mail: hong.shen1{at}bms.com
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Drug Metabolism and Disposition: 43 (7)
Drug Metabolism and Disposition
Vol. 43, Issue 7
1 Jul 2015
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Research ArticleArticle

OAT2 Contributes to Renal Tubular Transport of Creatinine

Hong Shen, Tongtong Liu, Bridget L. Morse, Yue Zhao, Yueping Zhang, Xi Qiu, Cliff Chen, Anne C. Lewin, Xi-Tao Wang, Guowen Liu, Lisa J. Christopher, Punit Marathe and Yurong Lai
Drug Metabolism and Disposition July 1, 2015, 43 (7) 984-993; DOI: https://doi.org/10.1124/dmd.114.062364

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Research ArticleArticle

OAT2 Contributes to Renal Tubular Transport of Creatinine

Hong Shen, Tongtong Liu, Bridget L. Morse, Yue Zhao, Yueping Zhang, Xi Qiu, Cliff Chen, Anne C. Lewin, Xi-Tao Wang, Guowen Liu, Lisa J. Christopher, Punit Marathe and Yurong Lai
Drug Metabolism and Disposition July 1, 2015, 43 (7) 984-993; DOI: https://doi.org/10.1124/dmd.114.062364
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