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Research ArticleArticle

Differences in Methadone Metabolism by CYP2B6 Variants

Sarah Gadel, Christina Friedel and Evan D. Kharasch
Drug Metabolism and Disposition July 2015, 43 (7) 994-1001; DOI: https://doi.org/10.1124/dmd.115.064352
Sarah Gadel
Department of Anesthesiology, Division of Clinical and Translational Research (S.G., C.F., E.D.K.) and the Department of Biochemistry and Molecular Biophysics (E.D.K.), Washington University in St. Louis, St. Louis, Missouri
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Christina Friedel
Department of Anesthesiology, Division of Clinical and Translational Research (S.G., C.F., E.D.K.) and the Department of Biochemistry and Molecular Biophysics (E.D.K.), Washington University in St. Louis, St. Louis, Missouri
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Evan D. Kharasch
Department of Anesthesiology, Division of Clinical and Translational Research (S.G., C.F., E.D.K.) and the Department of Biochemistry and Molecular Biophysics (E.D.K.), Washington University in St. Louis, St. Louis, Missouri
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Article Information

vol. 43 no. 7 994-1001
DOI 
https://doi.org/10.1124/dmd.115.064352
PubMed 
25897175

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 17, 2015
  • Accepted April 20, 2015
  • Published online May 18, 2015.

Article Versions

  • Earlier version (April 20, 2015 - 10:24).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sarah Gadel,
  2. Christina Friedel, and
  3. Evan D. Kharasch
  1. Department of Anesthesiology, Division of Clinical and Translational Research (S.G., C.F., E.D.K.) and the Department of Biochemistry and Molecular Biophysics (E.D.K.), Washington University in St. Louis, St. Louis, Missouri
  1. Address correspondence to:
    Dr. Evan D. Kharasch, Department of Anesthesiology, Washington University in St. Louis, 660 S. Euclid Ave., Campus Box 8054, St. Louis, MO 63110. E-mail: kharasch{at}wustl.edu
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Drug Metabolism and Disposition: 43 (7)
Drug Metabolism and Disposition
Vol. 43, Issue 7
1 Jul 2015
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Research ArticleArticle

Methadone Metabolism by CYP2B6 Variants

Sarah Gadel, Christina Friedel and Evan D. Kharasch
Drug Metabolism and Disposition July 1, 2015, 43 (7) 994-1001; DOI: https://doi.org/10.1124/dmd.115.064352

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Research ArticleArticle

Methadone Metabolism by CYP2B6 Variants

Sarah Gadel, Christina Friedel and Evan D. Kharasch
Drug Metabolism and Disposition July 1, 2015, 43 (7) 994-1001; DOI: https://doi.org/10.1124/dmd.115.064352
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