Research ArticleArticle
The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles
Amarjit S. Chaudhry, Bhagwat Prasad, Yoshiyuki Shirasaka, Alison Fohner, David Finkelstein, Yiping Fan, Shuoguo Wang, Gang Wu, Eleni Aklillu, Sarah C. Sim, Kenneth E. Thummel and Erin G. Schuetz
Drug Metabolism and Disposition August 2015, 43 (8) 1226-1235; DOI: https://doi.org/10.1124/dmd.115.064428
Amarjit S. Chaudhry
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
Bhagwat Prasad
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
Yoshiyuki Shirasaka
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
Alison Fohner
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
David Finkelstein
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
Yiping Fan
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
Shuoguo Wang
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
Gang Wu
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
Eleni Aklillu
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
Sarah C. Sim
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
Kenneth E. Thummel
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
Erin G. Schuetz
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., Y.S., A.F., K.E.T.); Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee (D.F., Y.F., S.W., G.W.); Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden (E.A.); and Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.C.S.)
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CYP2C19 Nonfunctional SNP rs12769205 Alters Splicing
Amarjit S. Chaudhry, Bhagwat Prasad, Yoshiyuki Shirasaka, Alison Fohner, David Finkelstein, Yiping Fan, Shuoguo Wang, Gang Wu, Eleni Aklillu, Sarah C. Sim, Kenneth E. Thummel and Erin G. Schuetz
Drug Metabolism and Disposition August 1, 2015, 43 (8) 1226-1235; DOI: https://doi.org/10.1124/dmd.115.064428
Research ArticleArticle
CYP2C19 Nonfunctional SNP rs12769205 Alters Splicing
Amarjit S. Chaudhry, Bhagwat Prasad, Yoshiyuki Shirasaka, Alison Fohner, David Finkelstein, Yiping Fan, Shuoguo Wang, Gang Wu, Eleni Aklillu, Sarah C. Sim, Kenneth E. Thummel and Erin G. Schuetz
Drug Metabolism and Disposition August 1, 2015, 43 (8) 1226-1235; DOI: https://doi.org/10.1124/dmd.115.064428
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