Research ArticleArticle
A Novel Loading Method for Doxycycline Liposomes for Intracellular Drug Delivery: Characterization of In Vitro and In Vivo Release Kinetics and Efficacy in a J774A.1 Cell Line Model of Mycobacterium smegmatis Infection
Rebekah K. Franklin, Sarah A. Marcus, Adel M. Talaat, Butch K. KuKanich, Ruth Sullivan, Lisa A. Krugner-Higby and Timothy D. Heath
Drug Metabolism and Disposition August 2015, 43 (8) 1236-1245; DOI: https://doi.org/10.1124/dmd.115.063602
Rebekah K. Franklin
Pharmacology, Clinical, Analytical, and Toxicological Services and the Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas (B.K.K.); and Departments of Surgical Sciences (L.A.K.-H.), Pathobiological Sciences (R.S.), and Comparative Biosciences (A.M.T., S.A.M.); School of Veterinary Medicine (R.S.); School of Pharmacy (T.D.H.); and Research Animal Resources Center, University of Wisconsin, Madison, Wisconsin (R.K.F., L.A.K.-H., R.S.)
Sarah A. Marcus
Pharmacology, Clinical, Analytical, and Toxicological Services and the Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas (B.K.K.); and Departments of Surgical Sciences (L.A.K.-H.), Pathobiological Sciences (R.S.), and Comparative Biosciences (A.M.T., S.A.M.); School of Veterinary Medicine (R.S.); School of Pharmacy (T.D.H.); and Research Animal Resources Center, University of Wisconsin, Madison, Wisconsin (R.K.F., L.A.K.-H., R.S.)
Adel M. Talaat
Pharmacology, Clinical, Analytical, and Toxicological Services and the Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas (B.K.K.); and Departments of Surgical Sciences (L.A.K.-H.), Pathobiological Sciences (R.S.), and Comparative Biosciences (A.M.T., S.A.M.); School of Veterinary Medicine (R.S.); School of Pharmacy (T.D.H.); and Research Animal Resources Center, University of Wisconsin, Madison, Wisconsin (R.K.F., L.A.K.-H., R.S.)
Butch K. KuKanich
Pharmacology, Clinical, Analytical, and Toxicological Services and the Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas (B.K.K.); and Departments of Surgical Sciences (L.A.K.-H.), Pathobiological Sciences (R.S.), and Comparative Biosciences (A.M.T., S.A.M.); School of Veterinary Medicine (R.S.); School of Pharmacy (T.D.H.); and Research Animal Resources Center, University of Wisconsin, Madison, Wisconsin (R.K.F., L.A.K.-H., R.S.)
Ruth Sullivan
Pharmacology, Clinical, Analytical, and Toxicological Services and the Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas (B.K.K.); and Departments of Surgical Sciences (L.A.K.-H.), Pathobiological Sciences (R.S.), and Comparative Biosciences (A.M.T., S.A.M.); School of Veterinary Medicine (R.S.); School of Pharmacy (T.D.H.); and Research Animal Resources Center, University of Wisconsin, Madison, Wisconsin (R.K.F., L.A.K.-H., R.S.)
Lisa A. Krugner-Higby
Pharmacology, Clinical, Analytical, and Toxicological Services and the Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas (B.K.K.); and Departments of Surgical Sciences (L.A.K.-H.), Pathobiological Sciences (R.S.), and Comparative Biosciences (A.M.T., S.A.M.); School of Veterinary Medicine (R.S.); School of Pharmacy (T.D.H.); and Research Animal Resources Center, University of Wisconsin, Madison, Wisconsin (R.K.F., L.A.K.-H., R.S.)
Timothy D. Heath
Pharmacology, Clinical, Analytical, and Toxicological Services and the Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas (B.K.K.); and Departments of Surgical Sciences (L.A.K.-H.), Pathobiological Sciences (R.S.), and Comparative Biosciences (A.M.T., S.A.M.); School of Veterinary Medicine (R.S.); School of Pharmacy (T.D.H.); and Research Animal Resources Center, University of Wisconsin, Madison, Wisconsin (R.K.F., L.A.K.-H., R.S.)
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Research ArticleArticle
Loading Liposome Doxycycline Pharmacokinetics Efficacy
Rebekah K. Franklin, Sarah A. Marcus, Adel M. Talaat, Butch K. KuKanich, Ruth Sullivan, Lisa A. Krugner-Higby and Timothy D. Heath
Drug Metabolism and Disposition August 1, 2015, 43 (8) 1236-1245; DOI: https://doi.org/10.1124/dmd.115.063602
Research ArticleArticle
Loading Liposome Doxycycline Pharmacokinetics Efficacy
Rebekah K. Franklin, Sarah A. Marcus, Adel M. Talaat, Butch K. KuKanich, Ruth Sullivan, Lisa A. Krugner-Higby and Timothy D. Heath
Drug Metabolism and Disposition August 1, 2015, 43 (8) 1236-1245; DOI: https://doi.org/10.1124/dmd.115.063602
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