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Index by author

September 01, 2015; Volume 43,Issue 9

A

  1. Ajamie, Rose T.

    1. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
      Thomas J. Raub, Graham N. Wishart, Palaniappan Kulanthaivel, Brian A. Staton, Rose T. Ajamie, Geri A. Sawada, Lawrence M. Gelbert, Harlan E. Shannon, Concepcion Sanchez-Martinez and Alfonso De Dios
      Drug Metabolism and Disposition September 2015, 43 (9) 1360-1371; DOI: https://doi.org/10.1124/dmd.114.062745

  2. Azuma, Yoshiaki

    1. SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      Wenqi Cui, Mengxi Sun, Nadezhda Galeva, Todd D. Williams, Yoshiaki Azuma and Jeff L. Staudinger
      Drug Metabolism and Disposition September 2015, 43 (9) 1316-1325; DOI: https://doi.org/10.1124/dmd.115.065201

B

  1. Barbara, Joanna E.

    1. Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor
      Faraz Kazmi, Phyllis Yerino, Joanna E. Barbara and Andrew Parkinson
      Drug Metabolism and Disposition September 2015, 43 (9) 1294-1302; DOI: https://doi.org/10.1124/dmd.115.065011

  2. Bian, Yicong

    1. Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes
      Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei and Su Zeng
      Drug Metabolism and Disposition September 2015, 43 (9) 1336-1340; DOI: https://doi.org/10.1124/dmd.115.064717

  3. Boucaut, David

    1. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist
      Hugues Chanteux, Ludovicus Staelens, Valérie Mancel, Brigitte Gerin, David Boucaut, Chandra Prakash and Jean-Marie Nicolas
      Drug Metabolism and Disposition September 2015, 43 (9) 1381-1391; DOI: https://doi.org/10.1124/dmd.115.064436

  4. Bromek, Ewa

    1. Damage to the Brain Serotonergic System Increases the Expression of Liver Cytochrome P450
      Marta Rysz, Ewa Bromek, Anna Haduch, Anna Sadakierska-Chudy and Władysława A. Daniel
      Drug Metabolism and Disposition September 2015, 43 (9) 1345-1352; DOI: https://doi.org/10.1124/dmd.115.064980

C

  1. Caron, Patrick

    1. Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
      Guillaume Margaillan, Michèle Rouleau, Kathrin Klein, John K. Fallon, Patrick Caron, Lyne Villeneuve, Philip C. Smith, Ulrich M. Zanger and Chantal Guillemette
      Drug Metabolism and Disposition September 2015, 43 (9) 1331-1335; DOI: https://doi.org/10.1124/dmd.115.065391

  2. Chanteux, Hugues

    1. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist
      Hugues Chanteux, Ludovicus Staelens, Valérie Mancel, Brigitte Gerin, David Boucaut, Chandra Prakash and Jean-Marie Nicolas
      Drug Metabolism and Disposition September 2015, 43 (9) 1381-1391; DOI: https://doi.org/10.1124/dmd.115.064436

  3. Chen, Gang

    1. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product–Drug Interaction
      Brandon T. Gufford, Gang Chen, Ana G. Vergara, Philip Lazarus, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition September 2015, 43 (9) 1353-1359; DOI: https://doi.org/10.1124/dmd.115.065086

  4. Cui, Wenqi

    1. SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      Wenqi Cui, Mengxi Sun, Nadezhda Galeva, Todd D. Williams, Yoshiaki Azuma and Jeff L. Staudinger
      Drug Metabolism and Disposition September 2015, 43 (9) 1316-1325; DOI: https://doi.org/10.1124/dmd.115.065201

D

  1. Daniel, Władysława A.

    1. Damage to the Brain Serotonergic System Increases the Expression of Liver Cytochrome P450
      Marta Rysz, Ewa Bromek, Anna Haduch, Anna Sadakierska-Chudy and Władysława A. Daniel
      Drug Metabolism and Disposition September 2015, 43 (9) 1345-1352; DOI: https://doi.org/10.1124/dmd.115.064980

  2. De Dios, Alfonso

    1. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
      Thomas J. Raub, Graham N. Wishart, Palaniappan Kulanthaivel, Brian A. Staton, Rose T. Ajamie, Geri A. Sawada, Lawrence M. Gelbert, Harlan E. Shannon, Concepcion Sanchez-Martinez and Alfonso De Dios
      Drug Metabolism and Disposition September 2015, 43 (9) 1360-1371; DOI: https://doi.org/10.1124/dmd.114.062745

  3. Ding, Xinxin

    1. Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms
      Lindsay B. Hough, Julia W. Nalwalk, Xinxin Ding and Nico Scheer
      Drug Metabolism and Disposition September 2015, 43 (9) 1326-1330; DOI: https://doi.org/10.1124/dmd.115.065490

F

  1. Fallon, John K.

    1. Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
      Guillaume Margaillan, Michèle Rouleau, Kathrin Klein, John K. Fallon, Patrick Caron, Lyne Villeneuve, Philip C. Smith, Ulrich M. Zanger and Chantal Guillemette
      Drug Metabolism and Disposition September 2015, 43 (9) 1331-1335; DOI: https://doi.org/10.1124/dmd.115.065391

  2. Fanslow, William C.

    1. Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker
      Brooke M. Rock, Mark E. Tometsko, Sonal K. Patel, Kevin J. Hamblett, William C. Fanslow and Dan A. Rock
      Drug Metabolism and Disposition September 2015, 43 (9) 1341-1344; DOI: https://doi.org/10.1124/dmd.115.064253

G

  1. Galeva, Nadezhda

    1. SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      Wenqi Cui, Mengxi Sun, Nadezhda Galeva, Todd D. Williams, Yoshiaki Azuma and Jeff L. Staudinger
      Drug Metabolism and Disposition September 2015, 43 (9) 1316-1325; DOI: https://doi.org/10.1124/dmd.115.065201

  2. Gelbert, Lawrence M.

    1. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
      Thomas J. Raub, Graham N. Wishart, Palaniappan Kulanthaivel, Brian A. Staton, Rose T. Ajamie, Geri A. Sawada, Lawrence M. Gelbert, Harlan E. Shannon, Concepcion Sanchez-Martinez and Alfonso De Dios
      Drug Metabolism and Disposition September 2015, 43 (9) 1360-1371; DOI: https://doi.org/10.1124/dmd.114.062745

  3. Gerin, Brigitte

    1. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist
      Hugues Chanteux, Ludovicus Staelens, Valérie Mancel, Brigitte Gerin, David Boucaut, Chandra Prakash and Jean-Marie Nicolas
      Drug Metabolism and Disposition September 2015, 43 (9) 1381-1391; DOI: https://doi.org/10.1124/dmd.115.064436

  4. Goldman, Jennifer L.

    1. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim
      Jennifer L. Goldman, J. Steven Leeder, Leon Van Haandel and Robin E. Pearce
      Drug Metabolism and Disposition September 2015, 43 (9) 1372-1380; DOI: https://doi.org/10.1124/dmd.115.065193

  5. Gufford, Brandon T.

    1. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product–Drug Interaction
      Brandon T. Gufford, Gang Chen, Ana G. Vergara, Philip Lazarus, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition September 2015, 43 (9) 1353-1359; DOI: https://doi.org/10.1124/dmd.115.065086

  6. Guillemette, Chantal

    1. Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
      Guillaume Margaillan, Michèle Rouleau, Kathrin Klein, John K. Fallon, Patrick Caron, Lyne Villeneuve, Philip C. Smith, Ulrich M. Zanger and Chantal Guillemette
      Drug Metabolism and Disposition September 2015, 43 (9) 1331-1335; DOI: https://doi.org/10.1124/dmd.115.065391

  7. Guo, Kenan

    1. Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes
      Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei and Su Zeng
      Drug Metabolism and Disposition September 2015, 43 (9) 1336-1340; DOI: https://doi.org/10.1124/dmd.115.064717

H

  1. Haduch, Anna

    1. Damage to the Brain Serotonergic System Increases the Expression of Liver Cytochrome P450
      Marta Rysz, Ewa Bromek, Anna Haduch, Anna Sadakierska-Chudy and Władysława A. Daniel
      Drug Metabolism and Disposition September 2015, 43 (9) 1345-1352; DOI: https://doi.org/10.1124/dmd.115.064980

  2. Hamblett, Kevin J.

    1. Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker
      Brooke M. Rock, Mark E. Tometsko, Sonal K. Patel, Kevin J. Hamblett, William C. Fanslow and Dan A. Rock
      Drug Metabolism and Disposition September 2015, 43 (9) 1341-1344; DOI: https://doi.org/10.1124/dmd.115.064253

  3. Hough, Lindsay B.

    1. Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms
      Lindsay B. Hough, Julia W. Nalwalk, Xinxin Ding and Nico Scheer
      Drug Metabolism and Disposition September 2015, 43 (9) 1326-1330; DOI: https://doi.org/10.1124/dmd.115.065490

  4. Hu, Haihong

    1. Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes
      Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei and Su Zeng
      Drug Metabolism and Disposition September 2015, 43 (9) 1336-1340; DOI: https://doi.org/10.1124/dmd.115.064717

J

  1. Jiang, Huidi

    1. Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes
      Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei and Su Zeng
      Drug Metabolism and Disposition September 2015, 43 (9) 1336-1340; DOI: https://doi.org/10.1124/dmd.115.064717

K

  1. Kazmi, Faraz

    1. Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor
      Faraz Kazmi, Phyllis Yerino, Joanna E. Barbara and Andrew Parkinson
      Drug Metabolism and Disposition September 2015, 43 (9) 1294-1302; DOI: https://doi.org/10.1124/dmd.115.065011

  2. Kitagawara, Yumina

    1. Novel Bioactivation Pathway of Benzbromarone Mediated by Cytochrome P450
      Yumina Kitagawara, Tomoyuki Ohe, Kumiko Tachibana, Kyoko Takahashi, Shigeo Nakamura and Tadahiko Mashino
      Drug Metabolism and Disposition September 2015, 43 (9) 1303-1306; DOI: https://doi.org/10.1124/dmd.115.065037

  3. Klein, Kathrin

    1. Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
      Guillaume Margaillan, Michèle Rouleau, Kathrin Klein, John K. Fallon, Patrick Caron, Lyne Villeneuve, Philip C. Smith, Ulrich M. Zanger and Chantal Guillemette
      Drug Metabolism and Disposition September 2015, 43 (9) 1331-1335; DOI: https://doi.org/10.1124/dmd.115.065391

  4. Kulanthaivel, Palaniappan

    1. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
      Thomas J. Raub, Graham N. Wishart, Palaniappan Kulanthaivel, Brian A. Staton, Rose T. Ajamie, Geri A. Sawada, Lawrence M. Gelbert, Harlan E. Shannon, Concepcion Sanchez-Martinez and Alfonso De Dios
      Drug Metabolism and Disposition September 2015, 43 (9) 1360-1371; DOI: https://doi.org/10.1124/dmd.114.062745

L

  1. Lazarus, Philip

    1. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product–Drug Interaction
      Brandon T. Gufford, Gang Chen, Ana G. Vergara, Philip Lazarus, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition September 2015, 43 (9) 1353-1359; DOI: https://doi.org/10.1124/dmd.115.065086

  2. Leeder, J. Steven

    1. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim
      Jennifer L. Goldman, J. Steven Leeder, Leon Van Haandel and Robin E. Pearce
      Drug Metabolism and Disposition September 2015, 43 (9) 1372-1380; DOI: https://doi.org/10.1124/dmd.115.065193

  3. Lei, Jinxiu

    1. Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes
      Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei and Su Zeng
      Drug Metabolism and Disposition September 2015, 43 (9) 1336-1340; DOI: https://doi.org/10.1124/dmd.115.064717

  4. Li, Hui

    1. Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study
      Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey and Haile F. Yancy
      Drug Metabolism and Disposition September 2015, 43 (9) 1392-1407; DOI: https://doi.org/10.1124/dmd.115.063735

M

  1. Mancel, Valérie

    1. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist
      Hugues Chanteux, Ludovicus Staelens, Valérie Mancel, Brigitte Gerin, David Boucaut, Chandra Prakash and Jean-Marie Nicolas
      Drug Metabolism and Disposition September 2015, 43 (9) 1381-1391; DOI: https://doi.org/10.1124/dmd.115.064436

  2. Margaillan, Guillaume

    1. Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
      Guillaume Margaillan, Michèle Rouleau, Kathrin Klein, John K. Fallon, Patrick Caron, Lyne Villeneuve, Philip C. Smith, Ulrich M. Zanger and Chantal Guillemette
      Drug Metabolism and Disposition September 2015, 43 (9) 1331-1335; DOI: https://doi.org/10.1124/dmd.115.065391

  3. Martinez, Marilyn

    1. Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study
      Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey and Haile F. Yancy
      Drug Metabolism and Disposition September 2015, 43 (9) 1392-1407; DOI: https://doi.org/10.1124/dmd.115.063735

  4. Mashino, Tadahiko

    1. Novel Bioactivation Pathway of Benzbromarone Mediated by Cytochrome P450
      Yumina Kitagawara, Tomoyuki Ohe, Kumiko Tachibana, Kyoko Takahashi, Shigeo Nakamura and Tadahiko Mashino
      Drug Metabolism and Disposition September 2015, 43 (9) 1303-1306; DOI: https://doi.org/10.1124/dmd.115.065037

  5. Myers, Michael J.

    1. Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study
      Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey and Haile F. Yancy
      Drug Metabolism and Disposition September 2015, 43 (9) 1392-1407; DOI: https://doi.org/10.1124/dmd.115.063735

N

  1. Nakamura, Shigeo

    1. Novel Bioactivation Pathway of Benzbromarone Mediated by Cytochrome P450
      Yumina Kitagawara, Tomoyuki Ohe, Kumiko Tachibana, Kyoko Takahashi, Shigeo Nakamura and Tadahiko Mashino
      Drug Metabolism and Disposition September 2015, 43 (9) 1303-1306; DOI: https://doi.org/10.1124/dmd.115.065037

  2. Nalwalk, Julia W.

    1. Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms
      Lindsay B. Hough, Julia W. Nalwalk, Xinxin Ding and Nico Scheer
      Drug Metabolism and Disposition September 2015, 43 (9) 1326-1330; DOI: https://doi.org/10.1124/dmd.115.065490

  3. Nicolas, Jean-Marie

    1. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist
      Hugues Chanteux, Ludovicus Staelens, Valérie Mancel, Brigitte Gerin, David Boucaut, Chandra Prakash and Jean-Marie Nicolas
      Drug Metabolism and Disposition September 2015, 43 (9) 1381-1391; DOI: https://doi.org/10.1124/dmd.115.064436

O

  1. Oberlies, Nicholas H.

    1. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product–Drug Interaction
      Brandon T. Gufford, Gang Chen, Ana G. Vergara, Philip Lazarus, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition September 2015, 43 (9) 1353-1359; DOI: https://doi.org/10.1124/dmd.115.065086

  2. Ohe, Tomoyuki

    1. Novel Bioactivation Pathway of Benzbromarone Mediated by Cytochrome P450
      Yumina Kitagawara, Tomoyuki Ohe, Kumiko Tachibana, Kyoko Takahashi, Shigeo Nakamura and Tadahiko Mashino
      Drug Metabolism and Disposition September 2015, 43 (9) 1303-1306; DOI: https://doi.org/10.1124/dmd.115.065037

P

  1. Paine, Mary F.

    1. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product–Drug Interaction
      Brandon T. Gufford, Gang Chen, Ana G. Vergara, Philip Lazarus, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition September 2015, 43 (9) 1353-1359; DOI: https://doi.org/10.1124/dmd.115.065086

  2. Parkinson, Andrew

    1. Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor
      Faraz Kazmi, Phyllis Yerino, Joanna E. Barbara and Andrew Parkinson
      Drug Metabolism and Disposition September 2015, 43 (9) 1294-1302; DOI: https://doi.org/10.1124/dmd.115.065011

  3. Patel, Sonal K.

    1. Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker
      Brooke M. Rock, Mark E. Tometsko, Sonal K. Patel, Kevin J. Hamblett, William C. Fanslow and Dan A. Rock
      Drug Metabolism and Disposition September 2015, 43 (9) 1341-1344; DOI: https://doi.org/10.1124/dmd.115.064253

  4. Pearce, Robin E.

    1. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim
      Jennifer L. Goldman, J. Steven Leeder, Leon Van Haandel and Robin E. Pearce
      Drug Metabolism and Disposition September 2015, 43 (9) 1372-1380; DOI: https://doi.org/10.1124/dmd.115.065193

  5. Prakash, Chandra

    1. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist
      Hugues Chanteux, Ludovicus Staelens, Valérie Mancel, Brigitte Gerin, David Boucaut, Chandra Prakash and Jean-Marie Nicolas
      Drug Metabolism and Disposition September 2015, 43 (9) 1381-1391; DOI: https://doi.org/10.1124/dmd.115.064436

Q

  1. Qiu, Junshan

    1. Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study
      Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey and Haile F. Yancy
      Drug Metabolism and Disposition September 2015, 43 (9) 1392-1407; DOI: https://doi.org/10.1124/dmd.115.063735

R

  1. Ramsden, Diane

    1. Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac
      Diane Ramsden, Jin Zhou and Donald J. Tweedie
      Drug Metabolism and Disposition September 2015, 43 (9) 1307-1315; DOI: https://doi.org/10.1124/dmd.115.065326

  2. Raub, Thomas J.

    1. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
      Thomas J. Raub, Graham N. Wishart, Palaniappan Kulanthaivel, Brian A. Staton, Rose T. Ajamie, Geri A. Sawada, Lawrence M. Gelbert, Harlan E. Shannon, Concepcion Sanchez-Martinez and Alfonso De Dios
      Drug Metabolism and Disposition September 2015, 43 (9) 1360-1371; DOI: https://doi.org/10.1124/dmd.114.062745

  3. Rock, Brooke M.

    1. Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker
      Brooke M. Rock, Mark E. Tometsko, Sonal K. Patel, Kevin J. Hamblett, William C. Fanslow and Dan A. Rock
      Drug Metabolism and Disposition September 2015, 43 (9) 1341-1344; DOI: https://doi.org/10.1124/dmd.115.064253

  4. Rock, Dan A.

    1. Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker
      Brooke M. Rock, Mark E. Tometsko, Sonal K. Patel, Kevin J. Hamblett, William C. Fanslow and Dan A. Rock
      Drug Metabolism and Disposition September 2015, 43 (9) 1341-1344; DOI: https://doi.org/10.1124/dmd.115.064253

  5. Rouleau, Michèle

    1. Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
      Guillaume Margaillan, Michèle Rouleau, Kathrin Klein, John K. Fallon, Patrick Caron, Lyne Villeneuve, Philip C. Smith, Ulrich M. Zanger and Chantal Guillemette
      Drug Metabolism and Disposition September 2015, 43 (9) 1331-1335; DOI: https://doi.org/10.1124/dmd.115.065391

  6. Rysz, Marta

    1. Damage to the Brain Serotonergic System Increases the Expression of Liver Cytochrome P450
      Marta Rysz, Ewa Bromek, Anna Haduch, Anna Sadakierska-Chudy and Władysława A. Daniel
      Drug Metabolism and Disposition September 2015, 43 (9) 1345-1352; DOI: https://doi.org/10.1124/dmd.115.064980

S

  1. Sadakierska-Chudy, Anna

    1. Damage to the Brain Serotonergic System Increases the Expression of Liver Cytochrome P450
      Marta Rysz, Ewa Bromek, Anna Haduch, Anna Sadakierska-Chudy and Władysława A. Daniel
      Drug Metabolism and Disposition September 2015, 43 (9) 1345-1352; DOI: https://doi.org/10.1124/dmd.115.064980

  2. Sanchez-Martinez, Concepcion

    1. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
      Thomas J. Raub, Graham N. Wishart, Palaniappan Kulanthaivel, Brian A. Staton, Rose T. Ajamie, Geri A. Sawada, Lawrence M. Gelbert, Harlan E. Shannon, Concepcion Sanchez-Martinez and Alfonso De Dios
      Drug Metabolism and Disposition September 2015, 43 (9) 1360-1371; DOI: https://doi.org/10.1124/dmd.114.062745

  3. Sawada, Geri A.

    1. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
      Thomas J. Raub, Graham N. Wishart, Palaniappan Kulanthaivel, Brian A. Staton, Rose T. Ajamie, Geri A. Sawada, Lawrence M. Gelbert, Harlan E. Shannon, Concepcion Sanchez-Martinez and Alfonso De Dios
      Drug Metabolism and Disposition September 2015, 43 (9) 1360-1371; DOI: https://doi.org/10.1124/dmd.114.062745

  4. Scheer, Nico

    1. Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms
      Lindsay B. Hough, Julia W. Nalwalk, Xinxin Ding and Nico Scheer
      Drug Metabolism and Disposition September 2015, 43 (9) 1326-1330; DOI: https://doi.org/10.1124/dmd.115.065490

  5. Shang, Haitao

    1. Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes
      Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei and Su Zeng
      Drug Metabolism and Disposition September 2015, 43 (9) 1336-1340; DOI: https://doi.org/10.1124/dmd.115.064717

  6. Shannon, Harlan E.

    1. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
      Thomas J. Raub, Graham N. Wishart, Palaniappan Kulanthaivel, Brian A. Staton, Rose T. Ajamie, Geri A. Sawada, Lawrence M. Gelbert, Harlan E. Shannon, Concepcion Sanchez-Martinez and Alfonso De Dios
      Drug Metabolism and Disposition September 2015, 43 (9) 1360-1371; DOI: https://doi.org/10.1124/dmd.114.062745

  7. Sharkey, Michele

    1. Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study
      Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey and Haile F. Yancy
      Drug Metabolism and Disposition September 2015, 43 (9) 1392-1407; DOI: https://doi.org/10.1124/dmd.115.063735

  8. Smith, Philip C.

    1. Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
      Guillaume Margaillan, Michèle Rouleau, Kathrin Klein, John K. Fallon, Patrick Caron, Lyne Villeneuve, Philip C. Smith, Ulrich M. Zanger and Chantal Guillemette
      Drug Metabolism and Disposition September 2015, 43 (9) 1331-1335; DOI: https://doi.org/10.1124/dmd.115.065391

  9. Staelens, Ludovicus

    1. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist
      Hugues Chanteux, Ludovicus Staelens, Valérie Mancel, Brigitte Gerin, David Boucaut, Chandra Prakash and Jean-Marie Nicolas
      Drug Metabolism and Disposition September 2015, 43 (9) 1381-1391; DOI: https://doi.org/10.1124/dmd.115.064436

  10. Staton, Brian A.

    1. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
      Thomas J. Raub, Graham N. Wishart, Palaniappan Kulanthaivel, Brian A. Staton, Rose T. Ajamie, Geri A. Sawada, Lawrence M. Gelbert, Harlan E. Shannon, Concepcion Sanchez-Martinez and Alfonso De Dios
      Drug Metabolism and Disposition September 2015, 43 (9) 1360-1371; DOI: https://doi.org/10.1124/dmd.114.062745

  11. Staudinger, Jeff L.

    1. SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      Wenqi Cui, Mengxi Sun, Nadezhda Galeva, Todd D. Williams, Yoshiaki Azuma and Jeff L. Staudinger
      Drug Metabolism and Disposition September 2015, 43 (9) 1316-1325; DOI: https://doi.org/10.1124/dmd.115.065201

  12. Sun, Mengxi

    1. SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      Wenqi Cui, Mengxi Sun, Nadezhda Galeva, Todd D. Williams, Yoshiaki Azuma and Jeff L. Staudinger
      Drug Metabolism and Disposition September 2015, 43 (9) 1316-1325; DOI: https://doi.org/10.1124/dmd.115.065201

T

  1. Tachibana, Kumiko

    1. Novel Bioactivation Pathway of Benzbromarone Mediated by Cytochrome P450
      Yumina Kitagawara, Tomoyuki Ohe, Kumiko Tachibana, Kyoko Takahashi, Shigeo Nakamura and Tadahiko Mashino
      Drug Metabolism and Disposition September 2015, 43 (9) 1303-1306; DOI: https://doi.org/10.1124/dmd.115.065037

  2. Takahashi, Kyoko

    1. Novel Bioactivation Pathway of Benzbromarone Mediated by Cytochrome P450
      Yumina Kitagawara, Tomoyuki Ohe, Kumiko Tachibana, Kyoko Takahashi, Shigeo Nakamura and Tadahiko Mashino
      Drug Metabolism and Disposition September 2015, 43 (9) 1303-1306; DOI: https://doi.org/10.1124/dmd.115.065037

  3. Tometsko, Mark E.

    1. Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker
      Brooke M. Rock, Mark E. Tometsko, Sonal K. Patel, Kevin J. Hamblett, William C. Fanslow and Dan A. Rock
      Drug Metabolism and Disposition September 2015, 43 (9) 1341-1344; DOI: https://doi.org/10.1124/dmd.115.064253

  4. Troutman, Lisa

    1. Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study
      Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey and Haile F. Yancy
      Drug Metabolism and Disposition September 2015, 43 (9) 1392-1407; DOI: https://doi.org/10.1124/dmd.115.063735

  5. Tweedie, Donald J.

    1. Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac
      Diane Ramsden, Jin Zhou and Donald J. Tweedie
      Drug Metabolism and Disposition September 2015, 43 (9) 1307-1315; DOI: https://doi.org/10.1124/dmd.115.065326

V

  1. Van Haandel, Leon

    1. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim
      Jennifer L. Goldman, J. Steven Leeder, Leon Van Haandel and Robin E. Pearce
      Drug Metabolism and Disposition September 2015, 43 (9) 1372-1380; DOI: https://doi.org/10.1124/dmd.115.065193

  2. Vergara, Ana G.

    1. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product–Drug Interaction
      Brandon T. Gufford, Gang Chen, Ana G. Vergara, Philip Lazarus, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition September 2015, 43 (9) 1353-1359; DOI: https://doi.org/10.1124/dmd.115.065086

  3. Villeneuve, Lyne

    1. Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
      Guillaume Margaillan, Michèle Rouleau, Kathrin Klein, John K. Fallon, Patrick Caron, Lyne Villeneuve, Philip C. Smith, Ulrich M. Zanger and Chantal Guillemette
      Drug Metabolism and Disposition September 2015, 43 (9) 1331-1335; DOI: https://doi.org/10.1124/dmd.115.065391

W

  1. Wei, Hong

    1. Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes
      Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei and Su Zeng
      Drug Metabolism and Disposition September 2015, 43 (9) 1336-1340; DOI: https://doi.org/10.1124/dmd.115.064717

  2. Williams, Todd D.

    1. SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes
      Wenqi Cui, Mengxi Sun, Nadezhda Galeva, Todd D. Williams, Yoshiaki Azuma and Jeff L. Staudinger
      Drug Metabolism and Disposition September 2015, 43 (9) 1316-1325; DOI: https://doi.org/10.1124/dmd.115.065201

  3. Wishart, Graham N.

    1. Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
      Thomas J. Raub, Graham N. Wishart, Palaniappan Kulanthaivel, Brian A. Staton, Rose T. Ajamie, Geri A. Sawada, Lawrence M. Gelbert, Harlan E. Shannon, Concepcion Sanchez-Martinez and Alfonso De Dios
      Drug Metabolism and Disposition September 2015, 43 (9) 1360-1371; DOI: https://doi.org/10.1124/dmd.114.062745

Y

  1. Yancy, Haile F.

    1. Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study
      Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey and Haile F. Yancy
      Drug Metabolism and Disposition September 2015, 43 (9) 1392-1407; DOI: https://doi.org/10.1124/dmd.115.063735

  2. Yao, Qingqing

    1. Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes
      Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei and Su Zeng
      Drug Metabolism and Disposition September 2015, 43 (9) 1336-1340; DOI: https://doi.org/10.1124/dmd.115.064717

  3. Yerino, Phyllis

    1. Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor
      Faraz Kazmi, Phyllis Yerino, Joanna E. Barbara and Andrew Parkinson
      Drug Metabolism and Disposition September 2015, 43 (9) 1294-1302; DOI: https://doi.org/10.1124/dmd.115.065011

  4. Yu, Lushan

    1. Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes
      Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei and Su Zeng
      Drug Metabolism and Disposition September 2015, 43 (9) 1336-1340; DOI: https://doi.org/10.1124/dmd.115.064717

Z

  1. Zanger, Ulrich M.

    1. Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
      Guillaume Margaillan, Michèle Rouleau, Kathrin Klein, John K. Fallon, Patrick Caron, Lyne Villeneuve, Philip C. Smith, Ulrich M. Zanger and Chantal Guillemette
      Drug Metabolism and Disposition September 2015, 43 (9) 1331-1335; DOI: https://doi.org/10.1124/dmd.115.065391

  2. Zeng, Su

    1. Expression of Bama Minipig and Human CYP3A Enzymes: Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes
      Yicong Bian, Qingqing Yao, Haitao Shang, Jinxiu Lei, Haihong Hu, Kenan Guo, Huidi Jiang, Lushan Yu, Hong Wei and Su Zeng
      Drug Metabolism and Disposition September 2015, 43 (9) 1336-1340; DOI: https://doi.org/10.1124/dmd.115.064717

  3. Zhou, Jin

    1. Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac
      Diane Ramsden, Jin Zhou and Donald J. Tweedie
      Drug Metabolism and Disposition September 2015, 43 (9) 1307-1315; DOI: https://doi.org/10.1124/dmd.115.065326
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