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Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker

Brooke M. Rock, Mark E. Tometsko, Sonal K. Patel, Kevin J. Hamblett, William C. Fanslow and Dan A. Rock
Drug Metabolism and Disposition September 2015, 43 (9) 1341-1344; DOI: https://doi.org/10.1124/dmd.115.064253

Article Information

vol. 43 no. 9 1341-1344
DOI 
https://doi.org/10.1124/dmd.115.064253
PubMed 
26101225
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 26, 2015
  • Accepted June 18, 2015
  • Published online July 22, 2015.

Article Versions

Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Brooke M. Rock,
  2. Mark E. Tometsko,
  3. Sonal K. Patel,
  4. Kevin J. Hamblett,
  5. William C. Fanslow, and
  6. Dan A. Rock
  1. Department of Pharmacokinetics and Drug Metabolism (B.M.R., D.A.R., S.K.P.) and Therapeutic Innovation Unit (K.J.H., M.E.T., W.C.F.), Amgen, Inc., Seattle, Washington
  1. Address correspondence to:
    Dr. Dan A. Rock, 1201 Amgen Court West, Seattle, WA. E-mail: drock{at}amgen.com
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Rapid CommunicationShort Communication

In Vitro Catabolism of a Noncleavable ADC

Brooke M. Rock, Mark E. Tometsko, Sonal K. Patel, Kevin J. Hamblett, William C. Fanslow and Dan A. Rock
Drug Metabolism and Disposition September 1, 2015, 43 (9) 1341-1344; DOI: https://doi.org/10.1124/dmd.115.064253
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