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Research ArticleArticle

Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product–Drug Interaction

Brandon T. Gufford, Gang Chen, Ana G. Vergara, Philip Lazarus, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition September 2015, 43 (9) 1353-1359; DOI: https://doi.org/10.1124/dmd.115.065086
Brandon T. Gufford
Experimental and Systems Pharmacology (B.T.G., M.F.P.) and Department of Pharmaceutical Sciences (G.C., A.G.V., P.L.), College of Pharmacy, Washington State University, Spokane, Washington; and Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina (N.H.O.)
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Gang Chen
Experimental and Systems Pharmacology (B.T.G., M.F.P.) and Department of Pharmaceutical Sciences (G.C., A.G.V., P.L.), College of Pharmacy, Washington State University, Spokane, Washington; and Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina (N.H.O.)
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Ana G. Vergara
Experimental and Systems Pharmacology (B.T.G., M.F.P.) and Department of Pharmaceutical Sciences (G.C., A.G.V., P.L.), College of Pharmacy, Washington State University, Spokane, Washington; and Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina (N.H.O.)
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Philip Lazarus
Experimental and Systems Pharmacology (B.T.G., M.F.P.) and Department of Pharmaceutical Sciences (G.C., A.G.V., P.L.), College of Pharmacy, Washington State University, Spokane, Washington; and Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina (N.H.O.)
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Nicholas H. Oberlies
Experimental and Systems Pharmacology (B.T.G., M.F.P.) and Department of Pharmaceutical Sciences (G.C., A.G.V., P.L.), College of Pharmacy, Washington State University, Spokane, Washington; and Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina (N.H.O.)
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Mary F. Paine
Experimental and Systems Pharmacology (B.T.G., M.F.P.) and Department of Pharmaceutical Sciences (G.C., A.G.V., P.L.), College of Pharmacy, Washington State University, Spokane, Washington; and Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina (N.H.O.)
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Article Information

vol. 43 no. 9 1353-1359
DOI 
https://doi.org/10.1124/dmd.115.065086
PubMed 
26070840

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 27, 2015
  • Accepted June 12, 2015
  • Published online July 24, 2015.

Article Versions

  • Earlier version (June 12, 2015 - 08:48).
  • Earlier version (July 14, 2015 - 06:31).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Brandon T. Gufford,
  2. Gang Chen,
  3. Ana G. Vergara,
  4. Philip Lazarus,
  5. Nicholas H. Oberlies, and
  6. Mary F. Paine
  1. Experimental and Systems Pharmacology (B.T.G., M.F.P.) and Department of Pharmaceutical Sciences (G.C., A.G.V., P.L.), College of Pharmacy, Washington State University, Spokane, Washington; and Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina (N.H.O.)
  1. Address correspondence to:
    Dr. Mary F. Paine, Experimental and Systems Pharmacology, Washington State University College of Pharmacy, PBS 341, PO Box 1495, Spokane, WA 99210-1495. E-mail: mary.paine{at}wsu.edu
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Drug Metabolism and Disposition: 43 (9)
Drug Metabolism and Disposition
Vol. 43, Issue 9
1 Sep 2015
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Research ArticleArticle

Inhibition of Raloxifene Glucuronidation by Milk Thistle

Brandon T. Gufford, Gang Chen, Ana G. Vergara, Philip Lazarus, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition September 1, 2015, 43 (9) 1353-1359; DOI: https://doi.org/10.1124/dmd.115.065086

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Research ArticleArticle

Inhibition of Raloxifene Glucuronidation by Milk Thistle

Brandon T. Gufford, Gang Chen, Ana G. Vergara, Philip Lazarus, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition September 1, 2015, 43 (9) 1353-1359; DOI: https://doi.org/10.1124/dmd.115.065086
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