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Research ArticleArticle

Influence of ABCB1 Genotype in Collies on the Pharmacokinetics and Pharmacodynamics of Loperamide in a Dose-Escalation Study

Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey and Haile F. Yancy
Drug Metabolism and Disposition September 2015, 43 (9) 1392-1407; DOI: https://doi.org/10.1124/dmd.115.063735
Michael J. Myers
Office of Research, Division of Applied Veterinary Research (M.J.M., H.F.Y.); Office of New Animal Drug Evaluation, Division of Scientific Support (J.Q) Office of New Animal Drug Evaluation (M.M.); Office of Research, Division of Residue Chemistry (H.L.); Office of New Animal Drug Evaluation, Division of Therapeutic Drugs for Non-Food Animals (L.T., M.S.)—Center for Veterinary Medicine,US Food and Drug Administration, Silver Spring, Maryland
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Marilyn Martinez
Office of Research, Division of Applied Veterinary Research (M.J.M., H.F.Y.); Office of New Animal Drug Evaluation, Division of Scientific Support (J.Q) Office of New Animal Drug Evaluation (M.M.); Office of Research, Division of Residue Chemistry (H.L.); Office of New Animal Drug Evaluation, Division of Therapeutic Drugs for Non-Food Animals (L.T., M.S.)—Center for Veterinary Medicine,US Food and Drug Administration, Silver Spring, Maryland
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Hui Li
Office of Research, Division of Applied Veterinary Research (M.J.M., H.F.Y.); Office of New Animal Drug Evaluation, Division of Scientific Support (J.Q) Office of New Animal Drug Evaluation (M.M.); Office of Research, Division of Residue Chemistry (H.L.); Office of New Animal Drug Evaluation, Division of Therapeutic Drugs for Non-Food Animals (L.T., M.S.)—Center for Veterinary Medicine,US Food and Drug Administration, Silver Spring, Maryland
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Junshan Qiu
Office of Research, Division of Applied Veterinary Research (M.J.M., H.F.Y.); Office of New Animal Drug Evaluation, Division of Scientific Support (J.Q) Office of New Animal Drug Evaluation (M.M.); Office of Research, Division of Residue Chemistry (H.L.); Office of New Animal Drug Evaluation, Division of Therapeutic Drugs for Non-Food Animals (L.T., M.S.)—Center for Veterinary Medicine,US Food and Drug Administration, Silver Spring, Maryland
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Lisa Troutman
Office of Research, Division of Applied Veterinary Research (M.J.M., H.F.Y.); Office of New Animal Drug Evaluation, Division of Scientific Support (J.Q) Office of New Animal Drug Evaluation (M.M.); Office of Research, Division of Residue Chemistry (H.L.); Office of New Animal Drug Evaluation, Division of Therapeutic Drugs for Non-Food Animals (L.T., M.S.)—Center for Veterinary Medicine,US Food and Drug Administration, Silver Spring, Maryland
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Michele Sharkey
Office of Research, Division of Applied Veterinary Research (M.J.M., H.F.Y.); Office of New Animal Drug Evaluation, Division of Scientific Support (J.Q) Office of New Animal Drug Evaluation (M.M.); Office of Research, Division of Residue Chemistry (H.L.); Office of New Animal Drug Evaluation, Division of Therapeutic Drugs for Non-Food Animals (L.T., M.S.)—Center for Veterinary Medicine,US Food and Drug Administration, Silver Spring, Maryland
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Haile F. Yancy
Office of Research, Division of Applied Veterinary Research (M.J.M., H.F.Y.); Office of New Animal Drug Evaluation, Division of Scientific Support (J.Q) Office of New Animal Drug Evaluation (M.M.); Office of Research, Division of Residue Chemistry (H.L.); Office of New Animal Drug Evaluation, Division of Therapeutic Drugs for Non-Food Animals (L.T., M.S.)—Center for Veterinary Medicine,US Food and Drug Administration, Silver Spring, Maryland
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Article Information

vol. 43 no. 9 1392-1407
DOI 
https://doi.org/10.1124/dmd.115.063735
PubMed 
26153274

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 6, 2015
  • Accepted July 7, 2015
  • Published online August 5, 2015.

Article Versions

  • Earlier version (July 7, 2015 - 10:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Michael J. Myers,
  2. Marilyn Martinez,
  3. Hui Li,
  4. Junshan Qiu1,
  5. Lisa Troutman,
  6. Michele Sharkey, and
  7. Haile F. Yancy
  1. Office of Research, Division of Applied Veterinary Research (M.J.M., H.F.Y.); Office of New Animal Drug Evaluation, Division of Scientific Support (J.Q) Office of New Animal Drug Evaluation (M.M.); Office of Research, Division of Residue Chemistry (H.L.); Office of New Animal Drug Evaluation, Division of Therapeutic Drugs for Non-Food Animals (L.T., M.S.)—Center for Veterinary Medicine,US Food and Drug Administration, Silver Spring, Maryland
  1. Address correspondence to:
    Dr. Michael J. Myers, US Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Division of Applied Veterinary Research, 8401 Muirkirk Road, Laurel, MD, 20708. E-mail: michael.myers{at}fda.hhs.gov
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Drug Metabolism and Disposition: 43 (9)
Drug Metabolism and Disposition
Vol. 43, Issue 9
1 Sep 2015
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Research ArticleArticle

ABCB1 Genotype Influence on Loperamide PK/PD in Collies

Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey and Haile F. Yancy
Drug Metabolism and Disposition September 1, 2015, 43 (9) 1392-1407; DOI: https://doi.org/10.1124/dmd.115.063735

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Research ArticleArticle

ABCB1 Genotype Influence on Loperamide PK/PD in Collies

Michael J. Myers, Marilyn Martinez, Hui Li, Junshan Qiu, Lisa Troutman, Michele Sharkey and Haile F. Yancy
Drug Metabolism and Disposition September 1, 2015, 43 (9) 1392-1407; DOI: https://doi.org/10.1124/dmd.115.063735
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