Table of Contents

Articles

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  Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride

  Daichi Fujita, Yoshimasa Saito, Takeo Nakanishi and Ikumi Tamai

  Drug Metabolism and Disposition January 2016, 44 (1) 1-7; DOI: https://doi.org/10.1124/dmd.115.066712
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  Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1

  Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki and Hiroshi Yamazaki

  Drug Metabolism and Disposition January 2016, 44 (1) 8-15; DOI: https://doi.org/10.1124/dmd.115.067561
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  Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes

  Norikazu Matsunaga, Naomi Kaneko, Angelina Yukiko Staub, Takeo Nakanishi, Ken-ichi Nunoya, Haruo Imawaka and Ikumi Tamai

  Drug Metabolism and Disposition January 2016, 44 (1) 16-27; DOI: https://doi.org/10.1124/dmd.115.067074
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  Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [¹⁴C]Cobimetinib, a MEK Inhibitor, in Humans

  Ryan H. Takahashi, Edna F. Choo, Shuguang Ma, Susan Wong, Jason Halladay, Yuzhong Deng, Isabelle Rooney, Mary Gates, Cornelis E.C.A. Hop, S. Cyrus Khojasteh, Mark J. Dresser and Luna Musib

  Drug Metabolism and Disposition January 2016, 44 (1) 28-39; DOI: https://doi.org/10.1124/dmd.115.066282
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  Application of a New Dynamic Model to Predict the In Vitro Intrinsic Clearance of Tolbutamide Using Rat Microsomes Encapsulated in a Fab Hydrogel

  Ning Zhou, Yuanting Zheng, Junfen Xing, Huiying Yang, Hanmei Chen, Xiaoqiang Xiang, Jing Liu, Shanshan Tong, Bin Zhu and Weimin Cai

  Drug Metabolism and Disposition January 2016, 44 (1) 40-49; DOI: https://doi.org/10.1124/dmd.115.066092
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  Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG Cells

  Hélène Vermet, Nathalie Raoust, Robert Ngo, Luc Esserméant, Sylvie Klieber, Gérard Fabre and Xavier Boulenc

  Drug Metabolism and Disposition January 2016, 44 (1) 50-60; DOI: https://doi.org/10.1124/dmd.115.065581
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  Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon β in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes

  Pranav Shah, Ozozoma Omoluabi, Bhagavatula Moorthy and Romi Ghose

  Drug Metabolism and Disposition January 2016, 44 (1) 61-67; DOI: https://doi.org/10.1124/dmd.115.066761
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  Local Drug–Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart

  Ryota Takeuchi, Kohki Shinozaki, Takeo Nakanishi and Ikumi Tamai

  Drug Metabolism and Disposition January 2016, 44 (1) 68-74; DOI: https://doi.org/10.1124/dmd.115.066654
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  Altered Cisatracurium Pharmacokinetics and Pharmacodynamics in Patients with Congenital Heart Defects

  Zhufeng Wu, Sheng Wang, Xuemei Peng, Chunying Lu, Xiaodong Ye and Baojian Wu

  Drug Metabolism and Disposition January 2016, 44 (1) 75-82; DOI: https://doi.org/10.1124/dmd.115.067405
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  In Vitro Kinetic Characterization of Axitinib Metabolism

  Michael A. Zientek, Theunis C. Goosen, Elaine Tseng, Jian Lin, Jonathan N. Bauman, Gregory S. Walker, Ping Kang, Ying Jiang, Sascha Freiwald, David Neul and Bill J. Smith

  Drug Metabolism and Disposition January 2016, 44 (1) 102-114; DOI: https://doi.org/10.1124/dmd.115.065615
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  Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase

  Miho Kazui, Yuji Ogura, Katsunobu Hagihara, Kazuishi Kubota and Atsushi Kurihara

  Drug Metabolism and Disposition January 2016, 44 (1) 115-123; DOI: https://doi.org/10.1124/dmd.115.066290
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  Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes

  Christine Lin, Julianne Shi, Amanda Moore and Salman R. Khetani

  Drug Metabolism and Disposition January 2016, 44 (1) 127-136; DOI: https://doi.org/10.1124/dmd.115.066027
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  Threonine-408 Regulates the Stability of Human Pregnane X Receptor through Its Phosphorylation and the CHIP/Chaperone-Autophagy Pathway

  Junko Sugatani, Yuji Noguchi, Yoshiki Hattori, Masahiko Yamaguchi, Yasuhiro Yamazaki and Akira Ikari

  Drug Metabolism and Disposition January 2016, 44 (1) 137-150; DOI: https://doi.org/10.1124/dmd.115.066308
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  In Vivo Profiling and Distribution of Known and Novel Phase I and Phase II Metabolites of Efavirenz in Plasma, Urine, and Cerebrospinal Fluid

  Manel Aouri, Catalina Barcelo, Béatrice Ternon, Matthias Cavassini, Alexia Anagnostopoulos, Sabine Yerly, Henry Hugues, Pietro Vernazza, Huldrych F. Günthard, Thierry Buclin, Amalio Telenti, Margalida Rotger, Laurent A. Decosterd and the Swiss HIV Cohort Study

  Drug Metabolism and Disposition January 2016, 44 (1) 151-161; DOI: https://doi.org/10.1124/dmd.115.065839