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Drug Metabolism & Disposition

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Table of Contents

January 01, 2016; Volume 44,Issue 1

Minireview

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    Key Findings from Preclinical and Clinical Drug Interaction Studies Presented in New Drug and Biological License Applications Approved by the Food and Drug Administration in 2014
    Jingjing Yu, Tasha K. Ritchie, Zhu Zhou and Isabelle Ragueneau-Majlessi
    Drug Metabolism and Disposition January 2016, 44 (1) 83-101; DOI: https://doi.org/10.1124/dmd.115.066720

Articles

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    Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride
    Daichi Fujita, Yoshimasa Saito, Takeo Nakanishi and Ikumi Tamai
    Drug Metabolism and Disposition January 2016, 44 (1) 1-7; DOI: https://doi.org/10.1124/dmd.115.066712
  • Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1
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    Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1
    Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki and Hiroshi Yamazaki
    Drug Metabolism and Disposition January 2016, 44 (1) 8-15; DOI: https://doi.org/10.1124/dmd.115.067561
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    Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes
    Norikazu Matsunaga, Naomi Kaneko, Angelina Yukiko Staub, Takeo Nakanishi, Ken-ichi Nunoya, Haruo Imawaka and Ikumi Tamai
    Drug Metabolism and Disposition January 2016, 44 (1) 16-27; DOI: https://doi.org/10.1124/dmd.115.067074
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    Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans
    Ryan H. Takahashi, Edna F. Choo, Shuguang Ma, Susan Wong, Jason Halladay, Yuzhong Deng, Isabelle Rooney, Mary Gates, Cornelis E.C.A. Hop, S. Cyrus Khojasteh, Mark J. Dresser and Luna Musib
    Drug Metabolism and Disposition January 2016, 44 (1) 28-39; DOI: https://doi.org/10.1124/dmd.115.066282
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    Application of a New Dynamic Model to Predict the In Vitro Intrinsic Clearance of Tolbutamide Using Rat Microsomes Encapsulated in a Fab Hydrogel
    Ning Zhou, Yuanting Zheng, Junfen Xing, Huiying Yang, Hanmei Chen, Xiaoqiang Xiang, Jing Liu, Shanshan Tong, Bin Zhu and Weimin Cai
    Drug Metabolism and Disposition January 2016, 44 (1) 40-49; DOI: https://doi.org/10.1124/dmd.115.066092
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    Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG Cells
    Hélène Vermet, Nathalie Raoust, Robert Ngo, Luc Esserméant, Sylvie Klieber, Gérard Fabre and Xavier Boulenc
    Drug Metabolism and Disposition January 2016, 44 (1) 50-60; DOI: https://doi.org/10.1124/dmd.115.065581
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    Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon β in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes
    Pranav Shah, Ozozoma Omoluabi, Bhagavatula Moorthy and Romi Ghose
    Drug Metabolism and Disposition January 2016, 44 (1) 61-67; DOI: https://doi.org/10.1124/dmd.115.066761
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    Local Drug–Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart
    Ryota Takeuchi, Kohki Shinozaki, Takeo Nakanishi and Ikumi Tamai
    Drug Metabolism and Disposition January 2016, 44 (1) 68-74; DOI: https://doi.org/10.1124/dmd.115.066654
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    Altered Cisatracurium Pharmacokinetics and Pharmacodynamics in Patients with Congenital Heart Defects
    Zhufeng Wu, Sheng Wang, Xuemei Peng, Chunying Lu, Xiaodong Ye and Baojian Wu
    Drug Metabolism and Disposition January 2016, 44 (1) 75-82; DOI: https://doi.org/10.1124/dmd.115.067405
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    In Vitro Kinetic Characterization of Axitinib Metabolism
    Michael A. Zientek, Theunis C. Goosen, Elaine Tseng, Jian Lin, Jonathan N. Bauman, Gregory S. Walker, Ping Kang, Ying Jiang, Sascha Freiwald, David Neul and Bill J. Smith
    Drug Metabolism and Disposition January 2016, 44 (1) 102-114; DOI: https://doi.org/10.1124/dmd.115.065615
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    Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase
    Miho Kazui, Yuji Ogura, Katsunobu Hagihara, Kazuishi Kubota and Atsushi Kurihara
    Drug Metabolism and Disposition January 2016, 44 (1) 115-123; DOI: https://doi.org/10.1124/dmd.115.066290
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    Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes
    Christine Lin, Julianne Shi, Amanda Moore and Salman R. Khetani
    Drug Metabolism and Disposition January 2016, 44 (1) 127-136; DOI: https://doi.org/10.1124/dmd.115.066027
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    Threonine-408 Regulates the Stability of Human Pregnane X Receptor through Its Phosphorylation and the CHIP/Chaperone-Autophagy Pathway
    Junko Sugatani, Yuji Noguchi, Yoshiki Hattori, Masahiko Yamaguchi, Yasuhiro Yamazaki and Akira Ikari
    Drug Metabolism and Disposition January 2016, 44 (1) 137-150; DOI: https://doi.org/10.1124/dmd.115.066308
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    In Vivo Profiling and Distribution of Known and Novel Phase I and Phase II Metabolites of Efavirenz in Plasma, Urine, and Cerebrospinal Fluid
    Manel Aouri, Catalina Barcelo, Béatrice Ternon, Matthias Cavassini, Alexia Anagnostopoulos, Sabine Yerly, Henry Hugues, Pietro Vernazza, Huldrych F. Günthard, Thierry Buclin, Amalio Telenti, Margalida Rotger, Laurent A. Decosterd and the Swiss HIV Cohort Study
    Drug Metabolism and Disposition January 2016, 44 (1) 151-161; DOI: https://doi.org/10.1124/dmd.115.065839

Short Communication

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    Voriconazole-Induced Hepatitis via Simvastatin- and Lansoprazole-Mediated Drug Interactions: A Case Report and Review of the Literature
    Jose Luis Lopez and John A. Tayek
    Drug Metabolism and Disposition January 2016, 44 (1) 124-126; DOI: https://doi.org/10.1124/dmd.115.066878
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Drug Metabolism and Disposition: 44 (1)
Drug Metabolism and Disposition
Vol. 44, Issue 1
1 Jan 2016
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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