Research ArticleArticle
Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes
Norikazu Matsunaga, Naomi Kaneko, Angelina Yukiko Staub, Takeo Nakanishi, Ken-ichi Nunoya, Haruo Imawaka and Ikumi Tamai
Drug Metabolism and Disposition January 2016, 44 (1) 16-27; DOI: https://doi.org/10.1124/dmd.115.067074
Norikazu Matsunaga
Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (N.M., A.Y.S., T.N., I.T.); and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan (N.M., N.K., K.N., H.I.)
Naomi Kaneko
Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (N.M., A.Y.S., T.N., I.T.); and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan (N.M., N.K., K.N., H.I.)
Angelina Yukiko Staub
Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (N.M., A.Y.S., T.N., I.T.); and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan (N.M., N.K., K.N., H.I.)
Takeo Nakanishi
Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (N.M., A.Y.S., T.N., I.T.); and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan (N.M., N.K., K.N., H.I.)
Ken-ichi Nunoya
Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (N.M., A.Y.S., T.N., I.T.); and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan (N.M., N.K., K.N., H.I.)
Haruo Imawaka
Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (N.M., A.Y.S., T.N., I.T.); and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan (N.M., N.K., K.N., H.I.)
Ikumi Tamai
Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (N.M., A.Y.S., T.N., I.T.); and Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Tsukuba, Japan (N.M., N.K., K.N., H.I.)
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Research ArticleArticle
Modeling of Hepatic Disposition of Bosentan
Norikazu Matsunaga, Naomi Kaneko, Angelina Yukiko Staub, Takeo Nakanishi, Ken-ichi Nunoya, Haruo Imawaka and Ikumi Tamai
Drug Metabolism and Disposition January 1, 2016, 44 (1) 16-27; DOI: https://doi.org/10.1124/dmd.115.067074
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