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Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG Cells

Hélène Vermet, Nathalie Raoust, Robert Ngo, Luc Esserméant, Sylvie Klieber, Gérard Fabre and Xavier Boulenc
Drug Metabolism and Disposition January 2016, 44 (1) 50-60; DOI: https://doi.org/10.1124/dmd.115.065581

Article Information

vol. 44 no. 1 50-60
DOI 
https://doi.org/10.1124/dmd.115.065581
PubMed 
26467767
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 26, 2015
  • Accepted October 13, 2015
  • Published online November 25, 2015.

Article Versions

Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hélène Vermet,
  2. Nathalie Raoust,
  3. Robert Ngo,
  4. Luc Esserméant,
  5. Sylvie Klieber,
  6. Gérard Fabre, and
  7. Xavier Boulenc
  1. Drug Disposition Domain, Disposition, Safety and Animal Research Scientific Core Platform (H.V., N.R., R.N., S.K., G.F., X.B.); Biostatistics and Programming, Clinical Sciences & Operations, Scientific Core Platform (L.E.), Sanofi Recherche & Développement, Montpellier, France
  1. Address correspondence to:
    Dr. Xavier Boulenc, Sanofi R&D, 371 rue du Professeur J. Blayac, 34184 Montpellier, France. E-mail: xavier.boulenc{at}sanofi.com
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Research ArticleArticle

Normalization Methods To Predict CYP3A4 Induction

Hélène Vermet, Nathalie Raoust, Robert Ngo, Luc Esserméant, Sylvie Klieber, Gérard Fabre and Xavier Boulenc
Drug Metabolism and Disposition January 1, 2016, 44 (1) 50-60; DOI: https://doi.org/10.1124/dmd.115.065581
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