Table of Contents

Articles

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  Lansoprazole Exacerbates Pemetrexed-Mediated Hematologic Toxicity by Competitive Inhibition of Renal Basolateral Human Organic Anion Transporter 3

  Kenji Ikemura, Yugo Hamada, Chinatsu Kaya, Tomoyuki Enokiya, Yuichi Muraki, Hiroki Nakahara, Hajime Fujimoto, Tetsu Kobayashi, Takuya Iwamoto and Masahiro Okuda

  Drug Metabolism and Disposition October 2016, 44 (10) 1543-1549; DOI: https://doi.org/10.1124/dmd.116.070722
• Open Access

  Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis

  Howard J. Burt, Arian Emami Riedmaier, Matthew D. Harwood, H. Kim Crewe, Katherine L. Gill and Sibylle Neuhoff

  Drug Metabolism and Disposition October 2016, 44 (10) 1550-1561; DOI: https://doi.org/10.1124/dmd.116.071183
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  Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy

  Andrea Hubeny, Markus Keiser, Stefan Oswald, Gabriele Jedlitschky, Heyo K. Kroemer, Werner Siegmund and Markus Grube

  Drug Metabolism and Disposition October 2016, 44 (10) 1562-1568; DOI: https://doi.org/10.1124/dmd.116.069807
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  The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine

  Hoa Q. Nguyen, Ernesto Callegari and R. Scott Obach

  Drug Metabolism and Disposition October 2016, 44 (10) 1569-1578; DOI: https://doi.org/10.1124/dmd.116.071639
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  Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib

  Joanna K. Towles, Rebecca N. Clark, Michelle D. Wahlin, Vinita Uttamsingh, Allan E. Rettie and Klarissa D. Jackson

  Drug Metabolism and Disposition October 2016, 44 (10) 1584-1597; DOI: https://doi.org/10.1124/dmd.116.070839
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  Analysis of Mechanism-Based Inhibition of CYP 3A4 by a Series of Fluoroquinolone Antibacterial Agents

  Akiko Watanabe, Hideo Takakusa, Takako Kimura, Shin-ichi Inoue, Hiroyuki Kusuhara and Osamu Ando

  Drug Metabolism and Disposition October 2016, 44 (10) 1608-1616; DOI: https://doi.org/10.1124/dmd.116.071654
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  Clarification of the Mechanism of Clopidogrel-Mediated Drug–Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information

  Soo-Jin Kim, Takashi Yoshikado, Ichiro Ieiri, Kazuya Maeda, Miyuki Kimura, Shin Irie, Hiroyuki Kusuhara and Yuichi Sugiyama

  Drug Metabolism and Disposition October 2016, 44 (10) 1622-1632; DOI: https://doi.org/10.1124/dmd.116.070276
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  Determination of Unbound Partition Coefficient and in Vitro–in Vivo Extrapolation for SLC13A Transporter–Mediated Uptake

  Keith Riccardi, Zhenhong Li, Janice A. Brown, Matthew F. Gorgoglione, Mark Niosi, James Gosset, Kim Huard, Derek M. Erion and Li Di

  Drug Metabolism and Disposition October 2016, 44 (10) 1633-1642; DOI: https://doi.org/10.1124/dmd.116.071837
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  Methylation of the Constitutive Androstane Receptor Is Involved in the Suppression of CYP2C19 in Hepatitis B Virus–Associated Hepatocellular Carcinoma

  Xiaojing Tang, Lele Ge, Zhongjian Chen, Sisi Kong, Wenhui Liu, Yingchun Xu, Su Zeng and Shuqing Chen

  Drug Metabolism and Disposition October 2016, 44 (10) 1643-1652; DOI: https://doi.org/10.1124/dmd.116.070243
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  An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software

  Pranav Shah, Edward Kerns, Dac-Trung Nguyen, R. Scott Obach, Amy Q. Wang, Alexey Zakharov, John McKew, Anton Simeonov, Cornelis E. C. A. Hop and Xin Xu

  Drug Metabolism and Disposition October 2016, 44 (10) 1653-1661; DOI: https://doi.org/10.1124/dmd.116.072017
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  Characteristic Analysis of Intestinal Transport in Enterocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells

  Nao Kodama, Takahiro Iwao, Takahiro Katano, Kinya Ohta, Hiroaki Yuasa and Tamihide Matsunaga

  Drug Metabolism and Disposition October 2016, 44 (10) 1662-1667; DOI: https://doi.org/10.1124/dmd.116.069336
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  Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans

  Jason Boer, Ruth Young-Sciame, Fiona Lee, Kevin J. Bowman, Xiaoqing Yang, Jack G. Shi, Frank M. Nedza, William Frietze, Laurine Galya, Andrew P. Combs, Swamy Yeleswaram and Sharon Diamond

  Drug Metabolism and Disposition October 2016, 44 (10) 1668-1674; DOI: https://doi.org/10.1124/dmd.116.070680
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  In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity

  Johan Monbaliu, Martha Gonzalez, Apexa Bernard, James Jiao, Carlo Sensenhauser, Jan Snoeys, Hans Stieltjes, Inneke Wynant, Johan W. Smit and Caly Chien

  Drug Metabolism and Disposition October 2016, 44 (10) 1682-1691; DOI: https://doi.org/10.1124/dmd.116.070672
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  Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent

  Su-Er W. Huskey, Ry R. Forseth, Hongmei Li, Zhigang Jian, Alexandre Catoire, Jin Zhang, Tapan Ray, Handan He, Jimmy Flarakos and James B. Mangold

  Drug Metabolism and Disposition October 2016, 44 (10) 1697-1708; DOI: https://doi.org/10.1124/dmd.116.072108
• Open Access

  Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4′-OH-bupropion in vitro

  Jennifer E. Sager, Lauren S. L. Price and Nina Isoherranen

  Drug Metabolism and Disposition October 2016, 44 (10) 1709-1719; DOI: https://doi.org/10.1124/dmd.116.072363