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Drug Metabolism & Disposition

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Table of Contents

October 01, 2016; Volume 44,Issue 10

Perspective

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    Evaluation of CYP2B6 Induction and Prediction of Clinical Drug–Drug Interactions: Considerations from the IQ Consortium Induction Working Group—An Industry Perspective
    Odette A. Fahmi, Mohamad Shebley, Jairam Palamanda, Michael W. Sinz, Diane Ramsden, Heidi J. Einolf, Liangfu Chen and Hongbing Wang
    Drug Metabolism and Disposition October 2016, 44 (10) 1720-1730; DOI: https://doi.org/10.1124/dmd.116.071076

Minireview

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    Drug Transport by the Blood–Aqueous Humor Barrier of the Eye
    Jonghwa Lee and Ryan M. Pelis
    Drug Metabolism and Disposition October 2016, 44 (10) 1675-1681; DOI: https://doi.org/10.1124/dmd.116.069369

Articles

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    Lansoprazole Exacerbates Pemetrexed-Mediated Hematologic Toxicity by Competitive Inhibition of Renal Basolateral Human Organic Anion Transporter 3
    Kenji Ikemura, Yugo Hamada, Chinatsu Kaya, Tomoyuki Enokiya, Yuichi Muraki, Hiroki Nakahara, Hajime Fujimoto, Tetsu Kobayashi, Takuya Iwamoto and Masahiro Okuda
    Drug Metabolism and Disposition October 2016, 44 (10) 1543-1549; DOI: https://doi.org/10.1124/dmd.116.070722
  • Open Access
    Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis
    Howard J. Burt, Arian Emami Riedmaier, Matthew D. Harwood, H. Kim Crewe, Katherine L. Gill and Sibylle Neuhoff
    Drug Metabolism and Disposition October 2016, 44 (10) 1550-1561; DOI: https://doi.org/10.1124/dmd.116.071183
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    Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy
    Andrea Hubeny, Markus Keiser, Stefan Oswald, Gabriele Jedlitschky, Heyo K. Kroemer, Werner Siegmund and Markus Grube
    Drug Metabolism and Disposition October 2016, 44 (10) 1562-1568; DOI: https://doi.org/10.1124/dmd.116.069807
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    The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine
    Hoa Q. Nguyen, Ernesto Callegari and R. Scott Obach
    Drug Metabolism and Disposition October 2016, 44 (10) 1569-1578; DOI: https://doi.org/10.1124/dmd.116.071639
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    Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib
    Joanna K. Towles, Rebecca N. Clark, Michelle D. Wahlin, Vinita Uttamsingh, Allan E. Rettie and Klarissa D. Jackson
    Drug Metabolism and Disposition October 2016, 44 (10) 1584-1597; DOI: https://doi.org/10.1124/dmd.116.070839
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    Analysis of Mechanism-Based Inhibition of CYP 3A4 by a Series of Fluoroquinolone Antibacterial Agents
    Akiko Watanabe, Hideo Takakusa, Takako Kimura, Shin-ichi Inoue, Hiroyuki Kusuhara and Osamu Ando
    Drug Metabolism and Disposition October 2016, 44 (10) 1608-1616; DOI: https://doi.org/10.1124/dmd.116.071654
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    Clarification of the Mechanism of Clopidogrel-Mediated Drug–Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information
    Soo-Jin Kim, Takashi Yoshikado, Ichiro Ieiri, Kazuya Maeda, Miyuki Kimura, Shin Irie, Hiroyuki Kusuhara and Yuichi Sugiyama
    Drug Metabolism and Disposition October 2016, 44 (10) 1622-1632; DOI: https://doi.org/10.1124/dmd.116.070276
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    Determination of Unbound Partition Coefficient and in Vitro–in Vivo Extrapolation for SLC13A Transporter–Mediated Uptake
    Keith Riccardi, Zhenhong Li, Janice A. Brown, Matthew F. Gorgoglione, Mark Niosi, James Gosset, Kim Huard, Derek M. Erion and Li Di
    Drug Metabolism and Disposition October 2016, 44 (10) 1633-1642; DOI: https://doi.org/10.1124/dmd.116.071837
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    Methylation of the Constitutive Androstane Receptor Is Involved in the Suppression of CYP2C19 in Hepatitis B Virus–Associated Hepatocellular Carcinoma
    Xiaojing Tang, Lele Ge, Zhongjian Chen, Sisi Kong, Wenhui Liu, Yingchun Xu, Su Zeng and Shuqing Chen
    Drug Metabolism and Disposition October 2016, 44 (10) 1643-1652; DOI: https://doi.org/10.1124/dmd.116.070243
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    An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software
    Pranav Shah, Edward Kerns, Dac-Trung Nguyen, R. Scott Obach, Amy Q. Wang, Alexey Zakharov, John McKew, Anton Simeonov, Cornelis E. C. A. Hop and Xin Xu
    Drug Metabolism and Disposition October 2016, 44 (10) 1653-1661; DOI: https://doi.org/10.1124/dmd.116.072017
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    Characteristic Analysis of Intestinal Transport in Enterocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells
    Nao Kodama, Takahiro Iwao, Takahiro Katano, Kinya Ohta, Hiroaki Yuasa and Tamihide Matsunaga
    Drug Metabolism and Disposition October 2016, 44 (10) 1662-1667; DOI: https://doi.org/10.1124/dmd.116.069336
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    Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans
    Jason Boer, Ruth Young-Sciame, Fiona Lee, Kevin J. Bowman, Xiaoqing Yang, Jack G. Shi, Frank M. Nedza, William Frietze, Laurine Galya, Andrew P. Combs, Swamy Yeleswaram and Sharon Diamond
    Drug Metabolism and Disposition October 2016, 44 (10) 1668-1674; DOI: https://doi.org/10.1124/dmd.116.070680
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    In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity
    Johan Monbaliu, Martha Gonzalez, Apexa Bernard, James Jiao, Carlo Sensenhauser, Jan Snoeys, Hans Stieltjes, Inneke Wynant, Johan W. Smit and Caly Chien
    Drug Metabolism and Disposition October 2016, 44 (10) 1682-1691; DOI: https://doi.org/10.1124/dmd.116.070672
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    Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent
    Su-Er W. Huskey, Ry R. Forseth, Hongmei Li, Zhigang Jian, Alexandre Catoire, Jin Zhang, Tapan Ray, Handan He, Jimmy Flarakos and James B. Mangold
    Drug Metabolism and Disposition October 2016, 44 (10) 1697-1708; DOI: https://doi.org/10.1124/dmd.116.072108
  • Open Access
    Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4′-OH-bupropion in vitro
    Jennifer E. Sager, Lauren S. L. Price and Nina Isoherranen
    Drug Metabolism and Disposition October 2016, 44 (10) 1709-1719; DOI: https://doi.org/10.1124/dmd.116.072363

Short Communications

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    Morbid Obesity Alters Both Pharmacokinetics and Pharmacodynamics of Propofol: Dosing Recommendation for Anesthesia Induction
    Dong Dong, Xuemei Peng, Jie Liu, Hao Qian, Jiayang Li and Baojian Wu
    Drug Metabolism and Disposition October 2016, 44 (10) 1579-1583; DOI: https://doi.org/10.1124/dmd.116.071605
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    Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity
    Oliver T. Parkinson, Aaron M. Teitelbaum, Dale Whittington, Edward J. Kelly and Allan E. Rettie
    Drug Metabolism and Disposition October 2016, 44 (10) 1598-1602; DOI: https://doi.org/10.1124/dmd.116.070003
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    Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes
    Jennifer L. Goldman, Yakov M. Koen, Steven A. Rogers, Kelin Li, James S. Leeder and Robert P. Hanzlik
    Drug Metabolism and Disposition October 2016, 44 (10) 1603-1607; DOI: https://doi.org/10.1124/dmd.116.072041
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    Defining the Role of the NADH–Cytochrome-b5 Reductase 3 in the Mitochondrial Amidoxime Reducing Component Enzyme System
    Birte Plitzko, Antje Havemeyer, Bettina Bork, Florian Bittner, Ralf Mendel and Bernd Clement
    Drug Metabolism and Disposition October 2016, 44 (10) 1617-1621; DOI: https://doi.org/10.1124/dmd.116.071845
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    An Optimized Method for Protein Extraction from OCT-Embedded Human Kidney Tissue for Protein Quantification by LC-MS/MS Proteomics
    Marc Vrana, Anne Goodling, Maryam Afkarian and Bhagwat Prasad
    Drug Metabolism and Disposition October 2016, 44 (10) 1692-1696; DOI: https://doi.org/10.1124/dmd.116.071522
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Drug Metabolism and Disposition: 44 (10)
Drug Metabolism and Disposition
Vol. 44, Issue 10
1 Oct 2016
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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