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Research ArticleArticle

Methylation of the Constitutive Androstane Receptor Is Involved in the Suppression of CYP2C19 in Hepatitis B Virus–Associated Hepatocellular Carcinoma

Xiaojing Tang, Lele Ge, Zhongjian Chen, Sisi Kong, Wenhui Liu, Yingchun Xu, Su Zeng and Shuqing Chen
Drug Metabolism and Disposition October 2016, 44 (10) 1643-1652; DOI: https://doi.org/10.1124/dmd.116.070243
Xiaojing Tang
Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (X.T., W.L., Y.X., S.Z., S.C.); Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China (L.G.); and Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China (Z.C., S.K.)
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Lele Ge
Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (X.T., W.L., Y.X., S.Z., S.C.); Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China (L.G.); and Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China (Z.C., S.K.)
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Zhongjian Chen
Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (X.T., W.L., Y.X., S.Z., S.C.); Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China (L.G.); and Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China (Z.C., S.K.)
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Sisi Kong
Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (X.T., W.L., Y.X., S.Z., S.C.); Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China (L.G.); and Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China (Z.C., S.K.)
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Wenhui Liu
Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (X.T., W.L., Y.X., S.Z., S.C.); Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China (L.G.); and Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China (Z.C., S.K.)
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Yingchun Xu
Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (X.T., W.L., Y.X., S.Z., S.C.); Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China (L.G.); and Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China (Z.C., S.K.)
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Su Zeng
Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (X.T., W.L., Y.X., S.Z., S.C.); Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China (L.G.); and Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China (Z.C., S.K.)
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Shuqing Chen
Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (X.T., W.L., Y.X., S.Z., S.C.); Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China (L.G.); and Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China (Z.C., S.K.)
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Article Information

vol. 44 no. 10 1643-1652
DOI 
https://doi.org/10.1124/dmd.116.070243
PubMed 
27440862

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 27, 2016
  • Accepted July 18, 2016
  • Published online August 31, 2016.

Article Versions

  • Earlier version (July 20, 2016 - 07:30).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xiaojing Tang,
  2. Lele Ge,
  3. Zhongjian Chen,
  4. Sisi Kong,
  5. Wenhui Liu,
  6. Yingchun Xu,
  7. Su Zeng, and
  8. Shuqing Chen
  1. Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China (X.T., W.L., Y.X., S.Z., S.C.); Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China (L.G.); and Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, China (Z.C., S.K.)
  1. Address correspondence to:
    Shuqing Chen, Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China. E-mail: chenshuqing{at}zju.edu.cn
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Drug Metabolism and Disposition: 44 (10)
Drug Metabolism and Disposition
Vol. 44, Issue 10
1 Oct 2016
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Research ArticleArticle

Epigenetic Study of CYP2C19 in Hepatocellular Carcinoma

Xiaojing Tang, Lele Ge, Zhongjian Chen, Sisi Kong, Wenhui Liu, Yingchun Xu, Su Zeng and Shuqing Chen
Drug Metabolism and Disposition October 1, 2016, 44 (10) 1643-1652; DOI: https://doi.org/10.1124/dmd.116.070243

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Research ArticleArticle

Epigenetic Study of CYP2C19 in Hepatocellular Carcinoma

Xiaojing Tang, Lele Ge, Zhongjian Chen, Sisi Kong, Wenhui Liu, Yingchun Xu, Su Zeng and Shuqing Chen
Drug Metabolism and Disposition October 1, 2016, 44 (10) 1643-1652; DOI: https://doi.org/10.1124/dmd.116.070243
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