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Drug Metabolism & Disposition

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Table of Contents

November 01, 2016; Volume 44,Issue 11

Minireview

  • Open Access
    Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease
    Diede Fennema, Ian R. Phillips and Elizabeth A. Shephard
    Drug Metabolism and Disposition November 2016, 44 (11) 1839-1850; DOI: https://doi.org/10.1124/dmd.116.070615

Articles

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    Hepatic Clearance Predictions from In Vitro–In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System
    Christine M. Bowman and Leslie Z. Benet
    Drug Metabolism and Disposition November 2016, 44 (11) 1731-1735; DOI: https://doi.org/10.1124/dmd.116.071514
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    Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model
    Jae H. Chang, John Chen, Liling Liu, Kirsten Messick and Justin Ly
    Drug Metabolism and Disposition November 2016, 44 (11) 1736-1741; DOI: https://doi.org/10.1124/dmd.116.072132
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    A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver
    Feng Li, Pengcheng Wang, Ke Liu, Mariana G. Tarrago, Jie Lu, Eduardo N. Chini and Xiaochao Ma
    Drug Metabolism and Disposition November 2016, 44 (11) 1742-1751; DOI: https://doi.org/10.1124/dmd.116.070920
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    Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics
    Li Wang, Carol Collins, Edward J. Kelly, Xiaoyan Chu, Adrian S. Ray, Laurent Salphati, Guangqing Xiao, Caroline Lee, Yurong Lai, Mingxiang Liao, Anita Mathias, Raymond Evers, William Humphreys, Cornelis E. C. A. Hop, Sean C. Kumer and Jashvant D. Unadkat
    Drug Metabolism and Disposition November 2016, 44 (11) 1752-1758; DOI: https://doi.org/10.1124/dmd.116.071050
  • Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor
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    Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor
    Milu T. Cherian, Lei Yang, Sergio C. Chai, Wenwei Lin and Taosheng Chen
    Drug Metabolism and Disposition November 2016, 44 (11) 1759-1770; DOI: https://doi.org/10.1124/dmd.116.071993
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    Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition
    Hsia-lien Lin, Haoming Zhang, Cesar Kenaan and Paul F. Hollenberg
    Drug Metabolism and Disposition November 2016, 44 (11) 1771-1779; DOI: https://doi.org/10.1124/dmd.116.071662
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    Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis
    Matthew G. Burbank, Audrey Burban, Ahmad Sharanek, Richard J. Weaver, Christiane Guguen-Guillouzo and André Guillouzo
    Drug Metabolism and Disposition November 2016, 44 (11) 1780-1793; DOI: https://doi.org/10.1124/dmd.116.071373
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    Nonalcoholic Steatohepatitis Modulates Membrane Protein Retrieval and Insertion Processes
    A. L. Dzierlenga, J. D. Clarke and N. J. Cherrington
    Drug Metabolism and Disposition November 2016, 44 (11) 1799-1807; DOI: https://doi.org/10.1124/dmd.116.071415
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    The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model
    Junichi Takano, Kazuya Maeda, Michael B. Bolger and Yuichi Sugiyama
    Drug Metabolism and Disposition November 2016, 44 (11) 1808-1818; DOI: https://doi.org/10.1124/dmd.116.070011
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    The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates
    Luc R. A. Rougée, Michael A. Mohutsky, David W. Bedwell, Kenneth J. Ruterbories and Stephen D. Hall
    Drug Metabolism and Disposition November 2016, 44 (11) 1819-1827; DOI: https://doi.org/10.1124/dmd.116.071761
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    Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy
    Valentina M. Fokina, Meixiang Xu, Erik Rytting, Sherif Z. Abdel-Rahman, Holly West, Cheryl Oncken, Shannon M. Clark, Mahmoud S. Ahmed, Gary D.V. Hankins and Tatiana N. Nanovskaya
    Drug Metabolism and Disposition November 2016, 44 (11) 1832-1838; DOI: https://doi.org/10.1124/dmd.116.071530

Letter to the Editor

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    Misidentification of Bupropion Glucuronide Metabolites and Re-evaluation of Metabolite Pharmacokinetics
    Aaron M. Teitelbaum and Evan D. Kharasch
    Drug Metabolism and Disposition November 2016, 44 (11) 1851; DOI: https://doi.org/10.1124/dmd.116.072892

Short Communications

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    A Fragment-Based Approach for the Computational Prediction of the Nonspecific Binding of Drugs to Hepatic Microsomes
    Pramod C. Nair, Ross A. McKinnon and John O. Miners
    Drug Metabolism and Disposition November 2016, 44 (11) 1794-1798; DOI: https://doi.org/10.1124/dmd.116.071852
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    Evaluation of 24 CYP2D6 Variants on the Metabolism of Nebivolol In Vitro
    Xiaoxia Hu, Tian Lan, Dapeng Dai, Ren-ai Xu, Lingjing Yuan, Quan Zhou, Yunxuan Li, Jianping Cai and Guoxin Hu
    Drug Metabolism and Disposition November 2016, 44 (11) 1828-1831; DOI: https://doi.org/10.1124/dmd.116.071811
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    Pharmacokinetics and Disposition of Circulating Iridoids and Organic Acids in Rats Intravenously Receiving ReDuNing Injection
    Chen Cheng, Feifei Du, Ke Yu, Fang Xu, Fengqing Wang, Li Li, Olajide E. Olaleye, Junling Yang, Feng Chen, Chenchun Zhong, Qiongwei Liu, Jing Li, Zhenzhong Wang, Chuan Li and Wei Xiao
    Drug Metabolism and Disposition November 2016, 44 (11) 1853-1858; DOI: https://doi.org/10.1124/dmd.116.071647

Erratum

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    Correction to “Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo”
    Drug Metabolism and Disposition November 2016, 44 (11) 1852; DOI: https://doi.org/10.1124/dmd.115.068908err
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In this issue

Drug Metabolism and Disposition: 44 (11)
Drug Metabolism and Disposition
Vol. 44, Issue 11
1 Nov 2016
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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