Table of Contents

Articles

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  Hepatic Clearance Predictions from In Vitro–In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System

  Christine M. Bowman and Leslie Z. Benet

  Drug Metabolism and Disposition November 2016, 44 (11) 1731-1735; DOI: https://doi.org/10.1124/dmd.116.071514
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  Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model

  Jae H. Chang, John Chen, Liling Liu, Kirsten Messick and Justin Ly

  Drug Metabolism and Disposition November 2016, 44 (11) 1736-1741; DOI: https://doi.org/10.1124/dmd.116.072132
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  A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver

  Feng Li, Pengcheng Wang, Ke Liu, Mariana G. Tarrago, Jie Lu, Eduardo N. Chini and Xiaochao Ma

  Drug Metabolism and Disposition November 2016, 44 (11) 1742-1751; DOI: https://doi.org/10.1124/dmd.116.070920
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  Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics

  Li Wang, Carol Collins, Edward J. Kelly, Xiaoyan Chu, Adrian S. Ray, Laurent Salphati, Guangqing Xiao, Caroline Lee, Yurong Lai, Mingxiang Liao, Anita Mathias, Raymond Evers, William Humphreys, Cornelis E. C. A. Hop, Sean C. Kumer and Jashvant D. Unadkat

  Drug Metabolism and Disposition November 2016, 44 (11) 1752-1758; DOI: https://doi.org/10.1124/dmd.116.071050
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  Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor

  Milu T. Cherian, Lei Yang, Sergio C. Chai, Wenwei Lin and Taosheng Chen

  Drug Metabolism and Disposition November 2016, 44 (11) 1759-1770; DOI: https://doi.org/10.1124/dmd.116.071993
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  Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition

  Hsia-lien Lin, Haoming Zhang, Cesar Kenaan and Paul F. Hollenberg

  Drug Metabolism and Disposition November 2016, 44 (11) 1771-1779; DOI: https://doi.org/10.1124/dmd.116.071662
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  Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis

  Matthew G. Burbank, Audrey Burban, Ahmad Sharanek, Richard J. Weaver, Christiane Guguen-Guillouzo and André Guillouzo

  Drug Metabolism and Disposition November 2016, 44 (11) 1780-1793; DOI: https://doi.org/10.1124/dmd.116.071373
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  Nonalcoholic Steatohepatitis Modulates Membrane Protein Retrieval and Insertion Processes

  A. L. Dzierlenga, J. D. Clarke and N. J. Cherrington

  Drug Metabolism and Disposition November 2016, 44 (11) 1799-1807; DOI: https://doi.org/10.1124/dmd.116.071415
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  The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model

  Junichi Takano, Kazuya Maeda, Michael B. Bolger and Yuichi Sugiyama

  Drug Metabolism and Disposition November 2016, 44 (11) 1808-1818; DOI: https://doi.org/10.1124/dmd.116.070011
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  The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates

  Luc R. A. Rougée, Michael A. Mohutsky, David W. Bedwell, Kenneth J. Ruterbories and Stephen D. Hall

  Drug Metabolism and Disposition November 2016, 44 (11) 1819-1827; DOI: https://doi.org/10.1124/dmd.116.071761
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  Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy

  Valentina M. Fokina, Meixiang Xu, Erik Rytting, Sherif Z. Abdel-Rahman, Holly West, Cheryl Oncken, Shannon M. Clark, Mahmoud S. Ahmed, Gary D.V. Hankins and Tatiana N. Nanovskaya

  Drug Metabolism and Disposition November 2016, 44 (11) 1832-1838; DOI: https://doi.org/10.1124/dmd.116.071530