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Research ArticleArticle

A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver

Feng Li, Pengcheng Wang, Ke Liu, Mariana G. Tarrago, Jie Lu, Eduardo N. Chini and Xiaochao Ma
Drug Metabolism and Disposition November 2016, 44 (11) 1742-1751; DOI: https://doi.org/10.1124/dmd.116.070920
Feng Li
Department of Molecular and Cellular Biology, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas (F.L.); Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (P.W., K.L., J.L., X.M.), Laboratory of Signal Transduction, Department of Anesthesiology and Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, Minnesota (M.G.T., E.N.C.)
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Pengcheng Wang
Department of Molecular and Cellular Biology, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas (F.L.); Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (P.W., K.L., J.L., X.M.), Laboratory of Signal Transduction, Department of Anesthesiology and Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, Minnesota (M.G.T., E.N.C.)
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Ke Liu
Department of Molecular and Cellular Biology, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas (F.L.); Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (P.W., K.L., J.L., X.M.), Laboratory of Signal Transduction, Department of Anesthesiology and Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, Minnesota (M.G.T., E.N.C.)
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Mariana G. Tarrago
Department of Molecular and Cellular Biology, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas (F.L.); Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (P.W., K.L., J.L., X.M.), Laboratory of Signal Transduction, Department of Anesthesiology and Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, Minnesota (M.G.T., E.N.C.)
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Jie Lu
Department of Molecular and Cellular Biology, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas (F.L.); Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (P.W., K.L., J.L., X.M.), Laboratory of Signal Transduction, Department of Anesthesiology and Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, Minnesota (M.G.T., E.N.C.)
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Eduardo N. Chini
Department of Molecular and Cellular Biology, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas (F.L.); Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (P.W., K.L., J.L., X.M.), Laboratory of Signal Transduction, Department of Anesthesiology and Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, Minnesota (M.G.T., E.N.C.)
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Xiaochao Ma
Department of Molecular and Cellular Biology, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas (F.L.); Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (P.W., K.L., J.L., X.M.), Laboratory of Signal Transduction, Department of Anesthesiology and Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, Minnesota (M.G.T., E.N.C.)
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Article Information

vol. 44 no. 11 1742-1751
DOI 
https://doi.org/10.1124/dmd.116.070920
PubMed 
27531952

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 9, 2016
  • Accepted August 15, 2016
  • Published online October 3, 2016.

Article Versions

  • Earlier version (August 16, 2016 - 07:47).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Feng Li,
  2. Pengcheng Wang,
  3. Ke Liu,
  4. Mariana G. Tarrago,
  5. Jie Lu,
  6. Eduardo N. Chini, and
  7. Xiaochao Ma
  1. Department of Molecular and Cellular Biology, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, Texas (F.L.); Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (P.W., K.L., J.L., X.M.), Laboratory of Signal Transduction, Department of Anesthesiology and Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, Minnesota (M.G.T., E.N.C.)
  1. Address correspondence to:
    Xiaochao Ma, Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261. E-mail: mxiaocha{at}pitt.edu
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Drug Metabolism and Disposition: 44 (11)
Drug Metabolism and Disposition
Vol. 44, Issue 11
1 Nov 2016
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Research ArticleArticle

Acute Effect of Isoniazid on Liver Metabolome

Feng Li, Pengcheng Wang, Ke Liu, Mariana G. Tarrago, Jie Lu, Eduardo N. Chini and Xiaochao Ma
Drug Metabolism and Disposition November 1, 2016, 44 (11) 1742-1751; DOI: https://doi.org/10.1124/dmd.116.070920

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Research ArticleArticle

Acute Effect of Isoniazid on Liver Metabolome

Feng Li, Pengcheng Wang, Ke Liu, Mariana G. Tarrago, Jie Lu, Eduardo N. Chini and Xiaochao Ma
Drug Metabolism and Disposition November 1, 2016, 44 (11) 1742-1751; DOI: https://doi.org/10.1124/dmd.116.070920
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