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Drug Metabolism & Disposition

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Table of Contents

December 01, 2016; Volume 44,Issue 12

Commentary

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    When Is It Important to Measure Unbound Drug in Evaluating Nanomedicine Pharmacokinetics?
    Stephan T. Stern, Marilyn N. Martinez and David M. Stevens
    Drug Metabolism and Disposition December 2016, 44 (12) 1934-1939; DOI: https://doi.org/10.1124/dmd.116.073148

Minireview

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    Cytochrome P450 Organization and Function Are Modulated by Endoplasmic Reticulum Phospholipid Heterogeneity
    Lauren M. Brignac-Huber, Ji Won Park, James R. Reed and Wayne L. Backes
    Drug Metabolism and Disposition December 2016, 44 (12) 1859-1866; DOI: https://doi.org/10.1124/dmd.115.068981

Articles

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    Development of an Ecofriendly Anticoagulant Rodenticide Based on the Stereochemistry of Difenacoum
    Marlène Damin-Pernik, Bernadette Espana, Stéphane Besse, Isabelle Fourel, Hervé Caruel, Florence Popowycz, Etienne Benoit and Virginie Lattard
    Drug Metabolism and Disposition December 2016, 44 (12) 1872-1880; DOI: https://doi.org/10.1124/dmd.116.071688
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    Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma
    Laurent Salphati, Bruno Alicke, Timothy P. Heffron, Sheerin Shahidi-Latham, Merry Nishimura, Tim Cao, Richard A. Carano, Jonathan Cheong, Joan Greve, Hartmut Koeppen, Shari Lau, Leslie B. Lee, Michelle Nannini-Pepe, Jodie Pang, Emile G. Plise, Cristine Quiason, Linda Rangell, Xiaolin Zhang, Stephen E. Gould, Heidi S. Phillips and Alan G. Olivero
    Drug Metabolism and Disposition December 2016, 44 (12) 1881-1889; DOI: https://doi.org/10.1124/dmd.116.071423
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    Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine
    Kayoko Ohura, Hikaru Nishiyama, Saori Saco, Keisuke Kurokawa and Teruko Imai
    Drug Metabolism and Disposition December 2016, 44 (12) 1890-1898; DOI: https://doi.org/10.1124/dmd.116.072736
  • Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2′,5′-Tetrachlorobiphenyl
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    Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2′,5′-Tetrachlorobiphenyl
    Tsutomu Shimada, Kensaku Kakimoto, Shigeo Takenaka, Nobuyuki Koga, Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki, Donghak Kim, F. Peter Guengerich and Masayuki Komori
    Drug Metabolism and Disposition December 2016, 44 (12) 1899-1909; DOI: https://doi.org/10.1124/dmd.116.072991
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    Evaluation of the Interplay between Uptake Transport and CYP3A4 Induction in Micropatterned Cocultured Hepatocytes
    Amanda Moore, Paresh P. Chothe, Hong Tsao and Niresh Hariparsad
    Drug Metabolism and Disposition December 2016, 44 (12) 1910-1919; DOI: https://doi.org/10.1124/dmd.116.072660
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    Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics
    Bhagwat Prasad, Katherine Johnson, Sarah Billington, Caroline Lee, Git W. Chung, Colin D.A. Brown, Edward J. Kelly, Jonathan Himmelfarb and Jashvant D. Unadkat
    Drug Metabolism and Disposition December 2016, 44 (12) 1920-1924; DOI: https://doi.org/10.1124/dmd.116.072066
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    Investigation of Endogenous Compounds Applicable to Drug–Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans
    Yuri Tsuruya, Koji Kato, Yamato Sano, Yuichiro Imamura, Kazuya Maeda, Yuji Kumagai, Yuichi Sugiyama and Hiroyuki Kusuhara
    Drug Metabolism and Disposition December 2016, 44 (12) 1925-1933; DOI: https://doi.org/10.1124/dmd.116.071472
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    Modeling Therapeutic Antibody–Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform
    Thomas J. Long, Patrick A. Cosgrove, Robert T. Dunn, Donna B. Stolz, Hisham Hamadeh, Cynthia Afshari, Helen McBride and Linda G. Griffith
    Drug Metabolism and Disposition December 2016, 44 (12) 1940-1948; DOI: https://doi.org/10.1124/dmd.116.071456
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    Pharmacokinetics and Differential Regulation of Cytochrome P450 Enzymes in Type 1 Allergic Mice
    Tadatoshi Tanino, Akira Komada, Koji Ueda, Toru Bando, Yukie Nojiri, Yukari Ueda and Eiichi Sakurai
    Drug Metabolism and Disposition December 2016, 44 (12) 1950-1957; DOI: https://doi.org/10.1124/dmd.116.072462
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    Tramadol Metabolism to O-Desmethyl Tramadol (M1) and N-Desmethyl Tramadol (M2) by Dog Liver Microsomes: Species Comparison and Identification of Responsible Canine Cytochrome P450s
    Tania E. Perez, Katrina L. Mealey, Tamara L. Grubb, Stephen A. Greene and Michael H. Court
    Drug Metabolism and Disposition December 2016, 44 (12) 1963-1972; DOI: https://doi.org/10.1124/dmd.116.071902

Short Communications

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    A Rare UGT2B7 Variant Creates a Novel N-Glycosylation Site at Codon 121 with Impaired Enzyme Activity
    Camille Girard-Bock, Marie-Odile Benoit-Biancamano, Lyne Villeneuve, Sylvie Desjardins and Chantal Guillemette
    Drug Metabolism and Disposition December 2016, 44 (12) 1867-1871; DOI: https://doi.org/10.1124/dmd.116.071860
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    Antibody Drug Conjugates Differentiate Uptake and DNA Alkylation of Pyrrolobenzodiazepines in Tumors from Organs of Xenograft Mice
    Yong Ma, S. Cyrus Khojasteh, Cornelis E.C.A. Hop, Hans K. Erickson, Andrew Polson, Thomas H. Pillow, Shang-Fan Yu, Hong Wang, Peter S. Dragovich and Donglu Zhang
    Drug Metabolism and Disposition December 2016, 44 (12) 1958-1962; DOI: https://doi.org/10.1124/dmd.116.073031

Erratum

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    Correction to “Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease”
    Drug Metabolism and Disposition December 2016, 44 (12) 1949; DOI: https://doi.org/10.1124/dmd.115.070615err
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Drug Metabolism and Disposition: 44 (12)
Drug Metabolism and Disposition
Vol. 44, Issue 12
1 Dec 2016
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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