Table of Contents

Articles

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  Development of an Ecofriendly Anticoagulant Rodenticide Based on the Stereochemistry of Difenacoum

  Marlène Damin-Pernik, Bernadette Espana, Stéphane Besse, Isabelle Fourel, Hervé Caruel, Florence Popowycz, Etienne Benoit and Virginie Lattard

  Drug Metabolism and Disposition December 2016, 44 (12) 1872-1880; DOI: https://doi.org/10.1124/dmd.116.071688
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  Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma

  Laurent Salphati, Bruno Alicke, Timothy P. Heffron, Sheerin Shahidi-Latham, Merry Nishimura, Tim Cao, Richard A. Carano, Jonathan Cheong, Joan Greve, Hartmut Koeppen, Shari Lau, Leslie B. Lee, Michelle Nannini-Pepe, Jodie Pang, Emile G. Plise, Cristine Quiason, Linda Rangell, Xiaolin Zhang, Stephen E. Gould, Heidi S. Phillips and Alan G. Olivero

  Drug Metabolism and Disposition December 2016, 44 (12) 1881-1889; DOI: https://doi.org/10.1124/dmd.116.071423
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  Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine

  Kayoko Ohura, Hikaru Nishiyama, Saori Saco, Keisuke Kurokawa and Teruko Imai

  Drug Metabolism and Disposition December 2016, 44 (12) 1890-1898; DOI: https://doi.org/10.1124/dmd.116.072736
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  Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2′,5′-Tetrachlorobiphenyl

  Tsutomu Shimada, Kensaku Kakimoto, Shigeo Takenaka, Nobuyuki Koga, Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki, Donghak Kim, F. Peter Guengerich and Masayuki Komori

  Drug Metabolism and Disposition December 2016, 44 (12) 1899-1909; DOI: https://doi.org/10.1124/dmd.116.072991
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  Evaluation of the Interplay between Uptake Transport and CYP3A4 Induction in Micropatterned Cocultured Hepatocytes

  Amanda Moore, Paresh P. Chothe, Hong Tsao and Niresh Hariparsad

  Drug Metabolism and Disposition December 2016, 44 (12) 1910-1919; DOI: https://doi.org/10.1124/dmd.116.072660
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  Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics

  Bhagwat Prasad, Katherine Johnson, Sarah Billington, Caroline Lee, Git W. Chung, Colin D.A. Brown, Edward J. Kelly, Jonathan Himmelfarb and Jashvant D. Unadkat

  Drug Metabolism and Disposition December 2016, 44 (12) 1920-1924; DOI: https://doi.org/10.1124/dmd.116.072066
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  Investigation of Endogenous Compounds Applicable to Drug–Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans

  Yuri Tsuruya, Koji Kato, Yamato Sano, Yuichiro Imamura, Kazuya Maeda, Yuji Kumagai, Yuichi Sugiyama and Hiroyuki Kusuhara

  Drug Metabolism and Disposition December 2016, 44 (12) 1925-1933; DOI: https://doi.org/10.1124/dmd.116.071472
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  Modeling Therapeutic Antibody–Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

  Thomas J. Long, Patrick A. Cosgrove, Robert T. Dunn, Donna B. Stolz, Hisham Hamadeh, Cynthia Afshari, Helen McBride and Linda G. Griffith

  Drug Metabolism and Disposition December 2016, 44 (12) 1940-1948; DOI: https://doi.org/10.1124/dmd.116.071456
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  Pharmacokinetics and Differential Regulation of Cytochrome P450 Enzymes in Type 1 Allergic Mice

  Tadatoshi Tanino, Akira Komada, Koji Ueda, Toru Bando, Yukie Nojiri, Yukari Ueda and Eiichi Sakurai

  Drug Metabolism and Disposition December 2016, 44 (12) 1950-1957; DOI: https://doi.org/10.1124/dmd.116.072462
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  Tramadol Metabolism to O-Desmethyl Tramadol (M1) and N-Desmethyl Tramadol (M2) by Dog Liver Microsomes: Species Comparison and Identification of Responsible Canine Cytochrome P450s

  Tania E. Perez, Katrina L. Mealey, Tamara L. Grubb, Stephen A. Greene and Michael H. Court

  Drug Metabolism and Disposition December 2016, 44 (12) 1963-1972; DOI: https://doi.org/10.1124/dmd.116.071902