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Rapid CommunicationShort Communication

Antibody Drug Conjugates Differentiate Uptake and DNA Alkylation of Pyrrolobenzodiazepines in Tumors from Organs of Xenograft Mice

Yong Ma, S. Cyrus Khojasteh, Cornelis E.C.A. Hop, Hans K. Erickson, Andrew Polson, Thomas H. Pillow, Shang-Fan Yu, Hong Wang, Peter S. Dragovich and Donglu Zhang
Drug Metabolism and Disposition December 2016, 44 (12) 1958-1962; DOI: https://doi.org/10.1124/dmd.116.073031
Yong Ma
Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
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S. Cyrus Khojasteh
Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
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Cornelis E.C.A. Hop
Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
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Hans K. Erickson
Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
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Andrew Polson
Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
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Thomas H. Pillow
Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
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Shang-Fan Yu
Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
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Hong Wang
Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
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Peter S. Dragovich
Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
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Donglu Zhang
Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
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Article Information

vol. 44 no. 12 1958-1962
DOI 
https://doi.org/10.1124/dmd.116.073031
PubMed 
27683653

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 8, 2016
  • Accepted September 26, 2016
  • Published online November 7, 2016.

Article Versions

  • Earlier version (September 28, 2016 - 06:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yong Ma,
  2. S. Cyrus Khojasteh,
  3. Cornelis E.C.A. Hop,
  4. Hans K. Erickson,
  5. Andrew Polson,
  6. Thomas H. Pillow,
  7. Shang-Fan Yu,
  8. Hong Wang,
  9. Peter S. Dragovich, and
  10. Donglu Zhang
  1. Drug Metabolism & Pharmacokinetics (Y.M., S.C.K., C.E.C.A.H., D.Z.), Discovery Chemistry (T.H.P., P.S.D.), Translational Oncology (A.P., S.-F.Y.), Protein Chemistry (H.K.E.), and Development Toxicology (H.W.), Genentech, South San Francisco, California
  1. Address correspondence to:
    Donglu Zhang, Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, CA 94080. E-mail: zhang.donglu{at}gene.com
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Drug Metabolism and Disposition: 44 (12)
Drug Metabolism and Disposition
Vol. 44, Issue 12
1 Dec 2016
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Mechanism of Action of ADC Carrying Pyrrolobenzodiazepine

Yong Ma, S. Cyrus Khojasteh, Cornelis E.C.A. Hop, Hans K. Erickson, Andrew Polson, Thomas H. Pillow, Shang-Fan Yu, Hong Wang, Peter S. Dragovich and Donglu Zhang
Drug Metabolism and Disposition December 1, 2016, 44 (12) 1958-1962; DOI: https://doi.org/10.1124/dmd.116.073031

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Rapid CommunicationShort Communication

Mechanism of Action of ADC Carrying Pyrrolobenzodiazepine

Yong Ma, S. Cyrus Khojasteh, Cornelis E.C.A. Hop, Hans K. Erickson, Andrew Polson, Thomas H. Pillow, Shang-Fan Yu, Hong Wang, Peter S. Dragovich and Donglu Zhang
Drug Metabolism and Disposition December 1, 2016, 44 (12) 1958-1962; DOI: https://doi.org/10.1124/dmd.116.073031
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