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Research ArticleArticle

Tramadol Metabolism to O-Desmethyl Tramadol (M1) and N-Desmethyl Tramadol (M2) by Dog Liver Microsomes: Species Comparison and Identification of Responsible Canine Cytochrome P450s

Tania E. Perez, Katrina L. Mealey, Tamara L. Grubb, Stephen A. Greene and Michael H. Court
Drug Metabolism and Disposition December 2016, 44 (12) 1963-1972; DOI: https://doi.org/10.1124/dmd.116.071902
Tania E. Perez
Program in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington
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Katrina L. Mealey
Program in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington
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Tamara L. Grubb
Program in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington
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Stephen A. Greene
Program in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington
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Michael H. Court
Program in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington
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Article Information

vol. 44 no. 12 1963-1972
DOI 
https://doi.org/10.1124/dmd.116.071902
PubMed 
27758804

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 3, 2016
  • Accepted October 5, 2016
  • Published online November 15, 2016.

Article Versions

  • Earlier version (October 6, 2016 - 11:10).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tania E. Perez,
  2. Katrina L. Mealey,
  3. Tamara L. Grubb,
  4. Stephen A. Greene, and
  5. Michael H. Court
  1. Program in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Pullman, Washington
  1. Address correspondence to:
    Dr. Tania E. Perez, Program in Individualized Medicine, Pharmacogenomics Laboratory, Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, 100 Grimes Way, Pullman, WA 99164. E-mail: tperez{at}vetmed.wsu.edu
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Drug Metabolism and Disposition: 44 (12)
Drug Metabolism and Disposition
Vol. 44, Issue 12
1 Dec 2016
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Research ArticleArticle

Tramadol Metabolism in Dogs

Tania E. Perez, Katrina L. Mealey, Tamara L. Grubb, Stephen A. Greene and Michael H. Court
Drug Metabolism and Disposition December 1, 2016, 44 (12) 1963-1972; DOI: https://doi.org/10.1124/dmd.116.071902

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Research ArticleArticle

Tramadol Metabolism in Dogs

Tania E. Perez, Katrina L. Mealey, Tamara L. Grubb, Stephen A. Greene and Michael H. Court
Drug Metabolism and Disposition December 1, 2016, 44 (12) 1963-1972; DOI: https://doi.org/10.1124/dmd.116.071902
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