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Research ArticleArticle

Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice

Vidya Ramakrishnan, Qi Joy Yang, Holly P. Quach, Yanguang Cao, Edwin C. Y. Chow, Donald E. Mager and K. Sandy Pang
Drug Metabolism and Disposition February 2016, 44 (2) 189-208; DOI: https://doi.org/10.1124/dmd.115.067033
Vidya Ramakrishnan
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., H.P.Q., E.C.Y.C., K.S.P.); and Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York (V.R., Y.C., D.E.M.)
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Qi Joy Yang
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., H.P.Q., E.C.Y.C., K.S.P.); and Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York (V.R., Y.C., D.E.M.)
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Holly P. Quach
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., H.P.Q., E.C.Y.C., K.S.P.); and Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York (V.R., Y.C., D.E.M.)
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Yanguang Cao
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., H.P.Q., E.C.Y.C., K.S.P.); and Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York (V.R., Y.C., D.E.M.)
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Edwin C. Y. Chow
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., H.P.Q., E.C.Y.C., K.S.P.); and Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York (V.R., Y.C., D.E.M.)
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Donald E. Mager
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., H.P.Q., E.C.Y.C., K.S.P.); and Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York (V.R., Y.C., D.E.M.)
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K. Sandy Pang
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., H.P.Q., E.C.Y.C., K.S.P.); and Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York (V.R., Y.C., D.E.M.)
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Article Information

vol. 44 no. 2 189-208
DOI 
https://doi.org/10.1124/dmd.115.067033
PubMed 
26586377

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 31, 2015
  • Accepted November 18, 2015
  • Published online January 7, 2016.

Article Versions

  • Earlier version (November 19, 2015 - 08:41).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Vidya Ramakrishnan1,
  2. Qi Joy Yang1,
  3. Holly P. Quach,
  4. Yanguang Cao2,
  5. Edwin C. Y. Chow,
  6. Donald E. Mager1, and
  7. K. Sandy Pang1
  1. Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada (Q.J.Y., H.P.Q., E.C.Y.C., K.S.P.); and Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York (V.R., Y.C., D.E.M.)
  1. Address correspondence to:
    Dr. K. Sandy Pang, Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University at Toronto, 144 College Street, Toronto, Ontario Canada. E-mail: ks.pang{at}utoronto.ca
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Drug Metabolism and Disposition: 44 (2)
Drug Metabolism and Disposition
Vol. 44, Issue 2
1 Feb 2016
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Research ArticleArticle

PBPK-PD Modeling of 1,25(OH)2D3 in Mice

Vidya Ramakrishnan, Qi Joy Yang, Holly P. Quach, Yanguang Cao, Edwin C. Y. Chow, Donald E. Mager and K. Sandy Pang
Drug Metabolism and Disposition February 1, 2016, 44 (2) 189-208; DOI: https://doi.org/10.1124/dmd.115.067033

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Research ArticleArticle

PBPK-PD Modeling of 1,25(OH)2D3 in Mice

Vidya Ramakrishnan, Qi Joy Yang, Holly P. Quach, Yanguang Cao, Edwin C. Y. Chow, Donald E. Mager and K. Sandy Pang
Drug Metabolism and Disposition February 1, 2016, 44 (2) 189-208; DOI: https://doi.org/10.1124/dmd.115.067033
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