Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn

Table of Contents

March 01, 2016; Volume 44,Issue 3

Commentary

  • You have access
    Absorption Differences between Immediate-Release Dexmethylphenidate and dl-Methylphenidate
    Kennerly S. Patrick and Arthur B. Straughn
    Drug Metabolism and Disposition March 2016, 44 (3) 418-421; DOI: https://doi.org/10.1124/dmd.115.067975

Minireview

  • You have access
    MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy
    Ai-Ming Yu, Ye Tian, Mei-Juan Tu, Pui Yan Ho and Joseph L. Jilek
    Drug Metabolism and Disposition March 2016, 44 (3) 308-319; DOI: https://doi.org/10.1124/dmd.115.067470

Symposium Reports

  • You have access
    Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
    Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
    Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

Articles

  • You have access
    SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
    Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
    Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009
  • You have access
    In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells
    Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
    Drug Metabolism and Disposition March 2016, 44 (3) 297-307; DOI: https://doi.org/10.1124/dmd.115.067371
  • You have access
    Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
    Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
    Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944
  • You have access
    Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism
    Yoshiyuki Yamaura, Brian D. Chapron, Zhican Wang, Jonathan Himmelfarb and Kenneth E. Thummel
    Drug Metabolism and Disposition March 2016, 44 (3) 329-335; DOI: https://doi.org/10.1124/dmd.115.068429
  • You have access
    Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
    Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
    Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969
  • You have access
    Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells
    Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
    Drug Metabolism and Disposition March 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647
  • You have access
    Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain
    Yukiko Sakakibara, Miki Katoh, Yuya Kondo and Masayuki Nadai
    Drug Metabolism and Disposition March 2016, 44 (3) 370-377; DOI: https://doi.org/10.1124/dmd.115.067439
  • You have access
    Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition
    Attarat Pattanawongsa, Pramod C. Nair, Andrew Rowland and John O. Miners
    Drug Metabolism and Disposition March 2016, 44 (3) 378-388; DOI: https://doi.org/10.1124/dmd.115.068213
  • You have access
    Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes
    Johan Nicolaï, Tom De Bruyn, Louise Thevelin, Patrick Augustijns and Pieter Annaert
    Drug Metabolism and Disposition March 2016, 44 (3) 389-397; DOI: https://doi.org/10.1124/dmd.115.068114
  • You have access
    Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure
    Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner
    Drug Metabolism and Disposition March 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795
  • You have access
    Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog
    Takaya Kurokawa, Tatsuki Fukami, Tomohiro Yoshida and Miki Nakajima
    Drug Metabolism and Disposition March 2016, 44 (3) 409-416; DOI: https://doi.org/10.1124/dmd.115.068221
  • Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
    You have access
    Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
    Sreekanth C. Narayanapillai, Linda B. von Weymarn, Steven G. Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S. Hecht, Sharon E. Murphy and Chengguo Xing
    Drug Metabolism and Disposition March 2016, 44 (3) 422-427; DOI: https://doi.org/10.1124/dmd.115.068387
  • You have access
    Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
    Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
    Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736
  • You have access
    Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds
    Michelle Schaefer, Gerhard Schänzle, Daniel Bischoff and Roderich D. Süssmuth
    Drug Metabolism and Disposition March 2016, 44 (3) 435-444; DOI: https://doi.org/10.1124/dmd.115.067348
  • You have access
    Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain
    Anna Haduch, Ewa Bromek, Jacek Wójcikowski, Krystyna Gołembiowska and Władysława A. Daniel
    Drug Metabolism and Disposition March 2016, 44 (3) 445-452; DOI: https://doi.org/10.1124/dmd.115.067413
  • You have access
    Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters
    Lydia M. M. Vermeer, Caleb D. Isringhausen, Brian W. Ogilvie and David B. Buckley
    Drug Metabolism and Disposition March 2016, 44 (3) 453-459; DOI: https://doi.org/10.1124/dmd.115.067744
  • You have access
    Novel Cytochrome P450 Reaction Phenotyping for Low-Clearance Compounds Using the Hepatocyte Relay Method
    Xin Yang, Karen Atkinson and Li Di
    Drug Metabolism and Disposition March 2016, 44 (3) 460-465; DOI: https://doi.org/10.1124/dmd.115.067876
  • You have access
    Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes
    Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
    Drug Metabolism and Disposition March 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985
  • You have access
    In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition
    Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
    Drug Metabolism and Disposition March 2016, 44 (3) 476-480; DOI: https://doi.org/10.1124/dmd.115.067777

Short Communications

  • You have access
    Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1–Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes
    Asmita Pant and Thomas A. Kocarek
    Drug Metabolism and Disposition March 2016, 44 (3) 352-355; DOI: https://doi.org/10.1124/dmd.115.068437
  • You have access
    Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice
    Helen J. Renaud, Curtis D. Klaassen and Iván L. Csanaky
    Drug Metabolism and Disposition March 2016, 44 (3) 366-369; DOI: https://doi.org/10.1124/dmd.115.064766

Errata

  • You have access
    Correction to: “Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay”
    Drug Metabolism and Disposition March 2016, 44 (3) 336; DOI: https://doi.org/10.1124/dmd.112.065425err
  • You have access
    Correction to “The Impact of Single Nucleotide Polymorphisms on Human Aldehyde Oxidase”
    Drug Metabolism and Disposition March 2016, 44 (3) 365; DOI: https://doi.org/10.1124/dmd.112.043828err
  • You have access
    Correction to “Effect of Age on The Hepatocellularity Number for Wistar Rats”
    Drug Metabolism and Disposition March 2016, 44 (3) 417; DOI: https://doi.org/10.1124/dmd.115.066381err
Back to top
PreviousNext

In this issue

Drug Metabolism and Disposition: 44 (3)
Drug Metabolism and Disposition
Vol. 44, Issue 3
1 Mar 2016
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Sign up for alerts

Jump to

  • Commentary
  • Minireview
  • Symposium Reports
  • Articles
  • Short Communications
  • Errata
  • Most Cited
  • Most Read
Loading
  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
More...
Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics