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Index by author

March 01, 2016; Volume 44,Issue 3

A

  1. Achour, Brahim

    1. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 297-307; DOI: https://doi.org/10.1124/dmd.115.067371
    2. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 476-480; DOI: https://doi.org/10.1124/dmd.115.067777

  2. Annaert, Pieter

    1. Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes
      Johan Nicolaï, Tom De Bruyn, Louise Thevelin, Patrick Augustijns and Pieter Annaert
      Drug Metabolism and Disposition March 2016, 44 (3) 389-397; DOI: https://doi.org/10.1124/dmd.115.068114

  3. Atkinson, Karen

    1. Novel Cytochrome P450 Reaction Phenotyping for Low-Clearance Compounds Using the Hepatocyte Relay Method
      Xin Yang, Karen Atkinson and Li Di
      Drug Metabolism and Disposition March 2016, 44 (3) 460-465; DOI: https://doi.org/10.1124/dmd.115.067876

  4. Augustijns, Patrick

    1. Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes
      Johan Nicolaï, Tom De Bruyn, Louise Thevelin, Patrick Augustijns and Pieter Annaert
      Drug Metabolism and Disposition March 2016, 44 (3) 389-397; DOI: https://doi.org/10.1124/dmd.115.068114

B

  1. Bi, Huichang

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  2. Bischoff, Daniel

    1. Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds
      Michelle Schaefer, Gerhard Schänzle, Daniel Bischoff and Roderich D. Süssmuth
      Drug Metabolism and Disposition March 2016, 44 (3) 435-444; DOI: https://doi.org/10.1124/dmd.115.067348

  3. Bromek, Ewa

    1. Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain
      Anna Haduch, Ewa Bromek, Jacek Wójcikowski, Krystyna Gołembiowska and Władysława A. Daniel
      Drug Metabolism and Disposition March 2016, 44 (3) 445-452; DOI: https://doi.org/10.1124/dmd.115.067413

  4. Buckley, David B.

    1. Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters
      Lydia M. M. Vermeer, Caleb D. Isringhausen, Brian W. Ogilvie and David B. Buckley
      Drug Metabolism and Disposition March 2016, 44 (3) 453-459; DOI: https://doi.org/10.1124/dmd.115.067744

  5. Burton, Aimee

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

C

  1. Carlson, Gordon

    1. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 297-307; DOI: https://doi.org/10.1124/dmd.115.067371
    2. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 476-480; DOI: https://doi.org/10.1124/dmd.115.067777

  2. Carmella, Steven G.

    1. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Sreekanth C. Narayanapillai, Linda B. von Weymarn, Steven G. Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S. Hecht, Sharon E. Murphy and Chengguo Xing
      Drug Metabolism and Disposition March 2016, 44 (3) 422-427; DOI: https://doi.org/10.1124/dmd.115.068387

  3. Chapron, Brian D.

    1. Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism
      Yoshiyuki Yamaura, Brian D. Chapron, Zhican Wang, Jonathan Himmelfarb and Kenneth E. Thummel
      Drug Metabolism and Disposition March 2016, 44 (3) 329-335; DOI: https://doi.org/10.1124/dmd.115.068429

  4. Chaudhry, Amarjit S.

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  5. Chavez-Eng, Cynthia

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

  6. Chen, Pan

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  7. Chen, Yixin

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  8. Chien, Huan-Chieh

    1. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells
      Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
      Drug Metabolism and Disposition March 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647

  9. Cooper, Curtis

    1. Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes
      Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
      Drug Metabolism and Disposition March 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985

  10. Csanaky, Iván L.

    1. Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice
      Helen J. Renaud, Curtis D. Klaassen and Iván L. Csanaky
      Drug Metabolism and Disposition March 2016, 44 (3) 366-369; DOI: https://doi.org/10.1124/dmd.115.064766

D

  1. Daniel, Władysława A.

    1. Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain
      Anna Haduch, Ewa Bromek, Jacek Wójcikowski, Krystyna Gołembiowska and Władysława A. Daniel
      Drug Metabolism and Disposition March 2016, 44 (3) 445-452; DOI: https://doi.org/10.1124/dmd.115.067413

  2. De Bruyn, Tom

    1. Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes
      Johan Nicolaï, Tom De Bruyn, Louise Thevelin, Patrick Augustijns and Pieter Annaert
      Drug Metabolism and Disposition March 2016, 44 (3) 389-397; DOI: https://doi.org/10.1124/dmd.115.068114

  3. Di, Li

    1. Novel Cytochrome P450 Reaction Phenotyping for Low-Clearance Compounds Using the Hepatocyte Relay Method
      Xin Yang, Karen Atkinson and Li Di
      Drug Metabolism and Disposition March 2016, 44 (3) 460-465; DOI: https://doi.org/10.1124/dmd.115.067876

E

  1. Elsby, Robert

    1. Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure
      Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner
      Drug Metabolism and Disposition March 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795

F

  1. Fan, Xiaomei

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  2. Fenner, Katherine

    1. Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure
      Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner
      Drug Metabolism and Disposition March 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795

  3. Fukami, Tatsuki

    1. Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog
      Takaya Kurokawa, Tatsuki Fukami, Tomohiro Yoshida and Miki Nakajima
      Drug Metabolism and Disposition March 2016, 44 (3) 409-416; DOI: https://doi.org/10.1124/dmd.115.068221

  4. Furlong, Michael T.

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

G

  1. Gheyas, Ferdous

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

  2. Giacomini, Kathleen M.

    1. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells
      Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
      Drug Metabolism and Disposition March 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647

  3. Gołembiowska, Krystyna

    1. Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain
      Anna Haduch, Ewa Bromek, Jacek Wójcikowski, Krystyna Gołembiowska and Władysława A. Daniel
      Drug Metabolism and Disposition March 2016, 44 (3) 445-452; DOI: https://doi.org/10.1124/dmd.115.067413

  4. Gutstein, David

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

H

  1. Haduch, Anna

    1. Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain
      Anna Haduch, Ewa Bromek, Jacek Wójcikowski, Krystyna Gołembiowska and Władysława A. Daniel
      Drug Metabolism and Disposition March 2016, 44 (3) 445-452; DOI: https://doi.org/10.1124/dmd.115.067413

  2. Han, Yong-Hae

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

  3. Hartmann, Georgy

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

  4. Harwood, Matthew D.

    1. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 297-307; DOI: https://doi.org/10.1124/dmd.115.067371
    2. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 476-480; DOI: https://doi.org/10.1124/dmd.115.067777

  5. Hecht, Stephen S.

    1. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Sreekanth C. Narayanapillai, Linda B. von Weymarn, Steven G. Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S. Hecht, Sharon E. Murphy and Chengguo Xing
      Drug Metabolism and Disposition March 2016, 44 (3) 422-427; DOI: https://doi.org/10.1124/dmd.115.068387

  6. Himmelfarb, Jonathan

    1. Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism
      Yoshiyuki Yamaura, Brian D. Chapron, Zhican Wang, Jonathan Himmelfarb and Kenneth E. Thummel
      Drug Metabolism and Disposition March 2016, 44 (3) 329-335; DOI: https://doi.org/10.1124/dmd.115.068429

  7. Ho, Pui Yan

    1. MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy
      Ai-Ming Yu, Ye Tian, Mei-Juan Tu, Pui Yan Ho and Joseph L. Jilek
      Drug Metabolism and Disposition March 2016, 44 (3) 308-319; DOI: https://doi.org/10.1124/dmd.115.067470

  8. Hu, Ming

    1. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
      Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
      Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009

  9. Huang, Min

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

I

  1. Isringhausen, Caleb D.

    1. Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters
      Lydia M. M. Vermeer, Caleb D. Isringhausen, Brian W. Ogilvie and David B. Buckley
      Drug Metabolism and Disposition March 2016, 44 (3) 453-459; DOI: https://doi.org/10.1124/dmd.115.067744

  2. Iyer, Ramaswamy A.

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

J

  1. Jackson, Tonya

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

  2. Jasper, Paul

    1. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells
      Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
      Drug Metabolism and Disposition March 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647

  3. Jeong, Hyunyoung

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  4. Jiang, Yiming

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  5. Jilek, Joseph L.

    1. MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy
      Ai-Ming Yu, Ye Tian, Mei-Juan Tu, Pui Yan Ho and Joseph L. Jilek
      Drug Metabolism and Disposition March 2016, 44 (3) 308-319; DOI: https://doi.org/10.1124/dmd.115.067470

  6. Johns, Douglas

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

K

  1. Katoh, Miki

    1. Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain
      Yukiko Sakakibara, Miki Katoh, Yuya Kondo and Masayuki Nadai
      Drug Metabolism and Disposition March 2016, 44 (3) 370-377; DOI: https://doi.org/10.1124/dmd.115.067439

  2. Klaassen, Curtis D.

    1. Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice
      Helen J. Renaud, Curtis D. Klaassen and Iván L. Csanaky
      Drug Metabolism and Disposition March 2016, 44 (3) 366-369; DOI: https://doi.org/10.1124/dmd.115.064766

  3. Kocarek, Thomas A.

    1. Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1–Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes
      Asmita Pant and Thomas A. Kocarek
      Drug Metabolism and Disposition March 2016, 44 (3) 352-355; DOI: https://doi.org/10.1124/dmd.115.068437

  4. Kole, Prashant

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

  5. Kondo, Yuya

    1. Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain
      Yukiko Sakakibara, Miki Katoh, Yuya Kondo and Masayuki Nadai
      Drug Metabolism and Disposition March 2016, 44 (3) 370-377; DOI: https://doi.org/10.1124/dmd.115.067439

  6. Kumar, Sanjeev

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

  7. Kurokawa, Takaya

    1. Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog
      Takaya Kurokawa, Tatsuki Fukami, Tomohiro Yoshida and Miki Nakajima
      Drug Metabolism and Disposition March 2016, 44 (3) 409-416; DOI: https://doi.org/10.1124/dmd.115.068221

L

  1. Lai, Yurong

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

  2. Lederman, Harmony

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

  3. Leitzman, Pablo

    1. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Sreekanth C. Narayanapillai, Linda B. von Weymarn, Steven G. Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S. Hecht, Sharon E. Murphy and Chengguo Xing
      Drug Metabolism and Disposition March 2016, 44 (3) 422-427; DOI: https://doi.org/10.1124/dmd.115.068387

  4. Li, Dongshun

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  5. Li, Xi

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  6. Lin, Yvonne S.

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  7. Liu, Tongtong

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

  8. Liu, Zhongqiu

    1. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
      Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
      Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009

  9. Lu, Linlin

    1. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
      Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
      Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009

  10. Lutz, Ryan

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

M

  1. Mandlekar, Sandhya

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

  2. Marathe, Punit

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

  3. Martin, Paul

    1. Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure
      Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner
      Drug Metabolism and Disposition March 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795

  4. Matta, Murali Krishna

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

  5. Maurer, Tristan S.

    1. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells
      Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
      Drug Metabolism and Disposition March 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647

  6. Miners, John O.

    1. Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition
      Attarat Pattanawongsa, Pramod C. Nair, Andrew Rowland and John O. Miners
      Drug Metabolism and Disposition March 2016, 44 (3) 378-388; DOI: https://doi.org/10.1124/dmd.115.068213

  7. Mitra, Kaushik

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

  8. Murphy, Sharon E.

    1. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Sreekanth C. Narayanapillai, Linda B. von Weymarn, Steven G. Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S. Hecht, Sharon E. Murphy and Chengguo Xing
      Drug Metabolism and Disposition March 2016, 44 (3) 422-427; DOI: https://doi.org/10.1124/dmd.115.068387

N

  1. Nadai, Masayuki

    1. Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain
      Yukiko Sakakibara, Miki Katoh, Yuya Kondo and Masayuki Nadai
      Drug Metabolism and Disposition March 2016, 44 (3) 370-377; DOI: https://doi.org/10.1124/dmd.115.067439

  2. Nair, Pramod C.

    1. Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition
      Attarat Pattanawongsa, Pramod C. Nair, Andrew Rowland and John O. Miners
      Drug Metabolism and Disposition March 2016, 44 (3) 378-388; DOI: https://doi.org/10.1124/dmd.115.068213

  3. Nakajima, Miki

    1. Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog
      Takaya Kurokawa, Tatsuki Fukami, Tomohiro Yoshida and Miki Nakajima
      Drug Metabolism and Disposition March 2016, 44 (3) 409-416; DOI: https://doi.org/10.1124/dmd.115.068221

  4. Narayanapillai, Sreekanth C.

    1. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Sreekanth C. Narayanapillai, Linda B. von Weymarn, Steven G. Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S. Hecht, Sharon E. Murphy and Chengguo Xing
      Drug Metabolism and Disposition March 2016, 44 (3) 422-427; DOI: https://doi.org/10.1124/dmd.115.068387

  5. Neuhoff, Sibylle

    1. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 297-307; DOI: https://doi.org/10.1124/dmd.115.067371
    2. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 476-480; DOI: https://doi.org/10.1124/dmd.115.067777

  6. Nicolaï, Johan

    1. Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes
      Johan Nicolaï, Tom De Bruyn, Louise Thevelin, Patrick Augustijns and Pieter Annaert
      Drug Metabolism and Disposition March 2016, 44 (3) 389-397; DOI: https://doi.org/10.1124/dmd.115.068114

O

  1. Ogilvie, Brian W.

    1. Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters
      Lydia M. M. Vermeer, Caleb D. Isringhausen, Brian W. Ogilvie and David B. Buckley
      Drug Metabolism and Disposition March 2016, 44 (3) 453-459; DOI: https://doi.org/10.1124/dmd.115.067744

P

  1. Paladino, Jordan

    1. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Sreekanth C. Narayanapillai, Linda B. von Weymarn, Steven G. Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S. Hecht, Sharon E. Murphy and Chengguo Xing
      Drug Metabolism and Disposition March 2016, 44 (3) 422-427; DOI: https://doi.org/10.1124/dmd.115.068387

  2. Pan, Xian

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  3. Pant, Asmita

    1. Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1–Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes
      Asmita Pant and Thomas A. Kocarek
      Drug Metabolism and Disposition March 2016, 44 (3) 352-355; DOI: https://doi.org/10.1124/dmd.115.068437

  4. Patrick, Kennerly S.

    1. Absorption Differences between Immediate-Release Dexmethylphenidate and dl-Methylphenidate
      Kennerly S. Patrick and Arthur B. Straughn
      Drug Metabolism and Disposition March 2016, 44 (3) 418-421; DOI: https://doi.org/10.1124/dmd.115.067975

  5. Pattanawongsa, Attarat

    1. Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition
      Attarat Pattanawongsa, Pramod C. Nair, Andrew Rowland and John O. Miners
      Drug Metabolism and Disposition March 2016, 44 (3) 378-388; DOI: https://doi.org/10.1124/dmd.115.068213

  6. Prasad, Bhagwat

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  7. Putluru, Siva Prasad

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

Q

  1. Qin, Xiaoling

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

R

  1. Ramsden, Diane

    1. Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes
      Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
      Drug Metabolism and Disposition March 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985

  2. Renaud, Helen J.

    1. Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice
      Helen J. Renaud, Curtis D. Klaassen and Iván L. Csanaky
      Drug Metabolism and Disposition March 2016, 44 (3) 366-369; DOI: https://doi.org/10.1124/dmd.115.064766

  3. Rodrigues, A. David

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

  4. Rostami-Hodjegan, Amin

    1. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 297-307; DOI: https://doi.org/10.1124/dmd.115.067371
    2. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 476-480; DOI: https://doi.org/10.1124/dmd.115.067777

  5. Rowland, Andrew

    1. Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition
      Attarat Pattanawongsa, Pramod C. Nair, Andrew Rowland and John O. Miners
      Drug Metabolism and Disposition March 2016, 44 (3) 378-388; DOI: https://doi.org/10.1124/dmd.115.068213

  6. Rowland, Lois

    1. Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes
      Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
      Drug Metabolism and Disposition March 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985

  7. Russell, Matthew R.

    1. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 297-307; DOI: https://doi.org/10.1124/dmd.115.067371
    2. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 476-480; DOI: https://doi.org/10.1124/dmd.115.067777

S

  1. Sabo, John P.

    1. Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes
      Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
      Drug Metabolism and Disposition March 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985

  2. Sakakibara, Yukiko

    1. Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain
      Yukiko Sakakibara, Miki Katoh, Yuya Kondo and Masayuki Nadai
      Drug Metabolism and Disposition March 2016, 44 (3) 370-377; DOI: https://doi.org/10.1124/dmd.115.067439

  3. Sane, Rucha S.

    1. Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes
      Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
      Drug Metabolism and Disposition March 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985

  4. Schaefer, Michelle

    1. Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds
      Michelle Schaefer, Gerhard Schänzle, Daniel Bischoff and Roderich D. Süssmuth
      Drug Metabolism and Disposition March 2016, 44 (3) 435-444; DOI: https://doi.org/10.1124/dmd.115.067348

  5. Schänzle, Gerhard

    1. Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds
      Michelle Schaefer, Gerhard Schänzle, Daniel Bischoff and Roderich D. Süssmuth
      Drug Metabolism and Disposition March 2016, 44 (3) 435-444; DOI: https://doi.org/10.1124/dmd.115.067348

  6. Schuetz, Erin G.

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  7. Scott, Dennis O.

    1. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells
      Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
      Drug Metabolism and Disposition March 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647

  8. Sharma, Pradeep

    1. Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure
      Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner
      Drug Metabolism and Disposition March 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795

  9. Shen, Xiaolan

    1. Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice
      Georgy Hartmann, Sanjeev Kumar, Douglas Johns, Ferdous Gheyas, David Gutstein, Xiaolan Shen, Aimee Burton, Harmony Lederman, Ryan Lutz, Tonya Jackson, Cynthia Chavez-Eng and Kaushik Mitra
      Drug Metabolism and Disposition March 2016, 44 (3) 428-434; DOI: https://doi.org/10.1124/dmd.115.067736

  10. Shi, Jian

    1. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
      Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
      Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009

  11. Shireman, Laura M.

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  12. Straughn, Arthur B.

    1. Absorption Differences between Immediate-Release Dexmethylphenidate and dl-Methylphenidate
      Kennerly S. Patrick and Arthur B. Straughn
      Drug Metabolism and Disposition March 2016, 44 (3) 418-421; DOI: https://doi.org/10.1124/dmd.115.067975

  13. Surry, Dominic

    1. Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure
      Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner
      Drug Metabolism and Disposition March 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795

  14. Süssmuth, Roderich D.

    1. Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds
      Michelle Schaefer, Gerhard Schänzle, Daniel Bischoff and Roderich D. Süssmuth
      Drug Metabolism and Disposition March 2016, 44 (3) 435-444; DOI: https://doi.org/10.1124/dmd.115.067348

T

  1. Tan, Huasen

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  2. Tay-Sontheimer, Jessica

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  3. Thevelin, Louise

    1. Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes
      Johan Nicolaï, Tom De Bruyn, Louise Thevelin, Patrick Augustijns and Pieter Annaert
      Drug Metabolism and Disposition March 2016, 44 (3) 389-397; DOI: https://doi.org/10.1124/dmd.115.068114

  4. Thummel, Kenneth E.

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900
    2. Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism
      Yoshiyuki Yamaura, Brian D. Chapron, Zhican Wang, Jonathan Himmelfarb and Kenneth E. Thummel
      Drug Metabolism and Disposition March 2016, 44 (3) 329-335; DOI: https://doi.org/10.1124/dmd.115.068429

  5. Tian, Ye

    1. MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy
      Ai-Ming Yu, Ye Tian, Mei-Juan Tu, Pui Yan Ho and Joseph L. Jilek
      Drug Metabolism and Disposition March 2016, 44 (3) 308-319; DOI: https://doi.org/10.1124/dmd.115.067470

  6. Tien, Yun-Chen

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  7. Ting, Naitee

    1. Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes
      Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
      Drug Metabolism and Disposition March 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985

  8. Tolsma, John

    1. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells
      Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
      Drug Metabolism and Disposition March 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647

  9. Tracy, Timothy S.

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  10. Tu, Mei-Juan

    1. MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy
      Ai-Ming Yu, Ye Tian, Mei-Juan Tu, Pui Yan Ho and Joseph L. Jilek
      Drug Metabolism and Disposition March 2016, 44 (3) 308-319; DOI: https://doi.org/10.1124/dmd.115.067470

  11. Tweedie, Donald J.

    1. Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes
      Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
      Drug Metabolism and Disposition March 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985

U

  1. Upadhyaya, Pramod

    1. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Sreekanth C. Narayanapillai, Linda B. von Weymarn, Steven G. Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S. Hecht, Sharon E. Murphy and Chengguo Xing
      Drug Metabolism and Disposition March 2016, 44 (3) 422-427; DOI: https://doi.org/10.1124/dmd.115.068387

V

  1. Vermeer, Lydia M. M.

    1. Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters
      Lydia M. M. Vermeer, Caleb D. Isringhausen, Brian W. Ogilvie and David B. Buckley
      Drug Metabolism and Disposition March 2016, 44 (3) 453-459; DOI: https://doi.org/10.1124/dmd.115.067744

  2. von Weymarn, Linda B.

    1. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Sreekanth C. Narayanapillai, Linda B. von Weymarn, Steven G. Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S. Hecht, Sharon E. Murphy and Chengguo Xing
      Drug Metabolism and Disposition March 2016, 44 (3) 422-427; DOI: https://doi.org/10.1124/dmd.115.068387

W

  1. Wang, Ying

    1. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
      Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
      Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009
    2. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  2. Wang, Zhican

    1. Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism
      Yoshiyuki Yamaura, Brian D. Chapron, Zhican Wang, Jonathan Himmelfarb and Kenneth E. Thummel
      Drug Metabolism and Disposition March 2016, 44 (3) 329-335; DOI: https://doi.org/10.1124/dmd.115.068429

  3. Warhurst, Geoffrey

    1. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 297-307; DOI: https://doi.org/10.1124/dmd.115.067371
    2. In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition
      Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition March 2016, 44 (3) 476-480; DOI: https://doi.org/10.1124/dmd.115.067777

  4. Whitcher-Johnstone, Andrea

    1. Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes
      Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
      Drug Metabolism and Disposition March 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985

  5. Wójcikowski, Jacek

    1. Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain
      Anna Haduch, Ewa Bromek, Jacek Wójcikowski, Krystyna Gołembiowska and Władysława A. Daniel
      Drug Metabolism and Disposition March 2016, 44 (3) 445-452; DOI: https://doi.org/10.1124/dmd.115.067413

  6. Wu, Peng

    1. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
      Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
      Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009

X

  1. Xing, Chengguo

    1. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
      Sreekanth C. Narayanapillai, Linda B. von Weymarn, Steven G. Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S. Hecht, Sharon E. Murphy and Chengguo Xing
      Drug Metabolism and Disposition March 2016, 44 (3) 422-427; DOI: https://doi.org/10.1124/dmd.115.068387

Y

  1. Yamaura, Yoshiyuki

    1. Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism
      Yoshiyuki Yamaura, Brian D. Chapron, Zhican Wang, Jonathan Himmelfarb and Kenneth E. Thummel
      Drug Metabolism and Disposition March 2016, 44 (3) 329-335; DOI: https://doi.org/10.1124/dmd.115.068429

  2. Yan, Tongmeng

    1. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
      Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
      Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009

  3. Yang, Xin

    1. Novel Cytochrome P450 Reaction Phenotyping for Low-Clearance Compounds Using the Hepatocyte Relay Method
      Xin Yang, Karen Atkinson and Li Di
      Drug Metabolism and Disposition March 2016, 44 (3) 460-465; DOI: https://doi.org/10.1124/dmd.115.067876

  4. Yang, Zheng

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

  5. Yee, Sook Wah

    1. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells
      Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
      Drug Metabolism and Disposition March 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647

  6. Yoshida, Tomohiro

    1. Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog
      Takaya Kurokawa, Tatsuki Fukami, Tomohiro Yoshida and Miki Nakajima
      Drug Metabolism and Disposition March 2016, 44 (3) 409-416; DOI: https://doi.org/10.1124/dmd.115.068221

  7. Yu, Ai-Ming

    1. MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy
      Ai-Ming Yu, Ye Tian, Mei-Juan Tu, Pui Yan Ho and Joseph L. Jilek
      Drug Metabolism and Disposition March 2016, 44 (3) 308-319; DOI: https://doi.org/10.1124/dmd.115.067470

  8. Yu, Jia

    1. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
      Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
      Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009

Z

  1. Zeng, Hang

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  2. Zeng, Xuezhen

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  3. Zhang, Yueping

    1. Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
      Yueping Zhang, Yong-Hae Han, Siva Prasad Putluru, Murali Krishna Matta, Prashant Kole, Sandhya Mandlekar, Michael T. Furlong, Tongtong Liu, Ramaswamy A. Iyer, Punit Marathe, Zheng Yang, Yurong Lai and A. David Rodrigues
      Drug Metabolism and Disposition March 2016, 44 (3) 320-328; DOI: https://doi.org/10.1124/dmd.115.066944

  4. Zheng, Haihui

    1. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
      Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
      Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009

  5. Zhong, Xiao-bo

    1. Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism
      Timothy S. Tracy, Amarjit S. Chaudhry, Bhagwat Prasad, Kenneth E. Thummel, Erin G. Schuetz, Xiao-bo Zhong, Yun-Chen Tien, Hyunyoung Jeong, Xian Pan, Laura M. Shireman, Jessica Tay-Sontheimer and Yvonne S. Lin
      Drug Metabolism and Disposition March 2016, 44 (3) 343-351; DOI: https://doi.org/10.1124/dmd.115.067900

  6. Zhou, Yawen

    1. Hepatoprotective Effects of Schisandra sphenanthera Extract against Lithocholic Acid–Induced Cholestasis in Male Mice Are Associated with Activation of the Pregnane X Receptor Pathway and Promotion of Liver Regeneration
      Hang Zeng, Dongshun Li, Xiaoling Qin, Pan Chen, Huasen Tan, Xuezhen Zeng, Xi Li, Xiaomei Fan, Yiming Jiang, Yawen Zhou, Yixin Chen, Ying Wang, Min Huang and Huichang Bi
      Drug Metabolism and Disposition March 2016, 44 (3) 337-342; DOI: https://doi.org/10.1124/dmd.115.066969

  7. Zhu, Lijun

    1. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
      Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
      Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009

  8. Zur, Arik A.

    1. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells
      Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
      Drug Metabolism and Disposition March 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647
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