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Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure

Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner
Drug Metabolism and Disposition March 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795

Article Information

vol. 44 no. 3 398-408
DOI 
https://doi.org/10.1124/dmd.115.066795
PubMed 
26700956
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 13, 2015
  • Accepted December 18, 2015
  • Published online February 9, 2016.

Article Versions

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Robert Elsby1,
  2. Paul Martin,
  3. Dominic Surry2,
  4. Pradeep Sharma, and
  5. Katherine Fenner
  1. DMPK, Drug Safety and Metabolism (R.E., D.S.), and Quantitative Clinical Pharmacology, (P.M.), AstraZeneca R&D Alderley Park, Macclesfield, Cheshire, United Kingdom; and DMPK, Drug Safety and Metabolism, AstraZeneca R&D Darwin, Cambridge, Cambridgeshire, United Kingdom (P.S., K.F.)
  1. Address correspondence to:
    Katherine Fenner, DMPK, Drug Safety and Metabolism, AstraZeneca R&D Darwin, Cambridge, Cambridgeshire, CB4 0WG, United Kingdom. E-mail: Katherine.Fenner{at}astrazeneca.com
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Inhibition of Intestinal BCRP Increases Rosuvastatin Exposure

Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner
Drug Metabolism and Disposition March 1, 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795
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