Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure

Robert Elsby; Paul Martin; Dominic Surry; Pradeep Sharma; Katherine Fenner

doi:10.1124/dmd.115.066795

Research ArticleArticle

Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure

Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner

Drug Metabolism and Disposition March 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795

Robert Elsby

DMPK, Drug Safety and Metabolism (R.E., D.S.), and Quantitative Clinical Pharmacology, (P.M.), AstraZeneca R&D Alderley Park, Macclesfield, Cheshire, United Kingdom; and DMPK, Drug Safety and Metabolism, AstraZeneca R&D Darwin, Cambridge, Cambridgeshire, United Kingdom (P.S., K.F.)

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Paul Martin

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Dominic Surry

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Pradeep Sharma

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Katherine Fenner

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Drug Metabolism and Disposition

Vol. 44, Issue 3

1 Mar 2016

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Research ArticleArticle

Inhibition of Intestinal BCRP Increases Rosuvastatin Exposure

Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner

Drug Metabolism and Disposition March 1, 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795

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Research ArticleArticle

Inhibition of Intestinal BCRP Increases Rosuvastatin Exposure

Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma and Katherine Fenner

Drug Metabolism and Disposition March 1, 2016, 44 (3) 398-408; DOI: https://doi.org/10.1124/dmd.115.066795

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Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure

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