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Research ArticleArticle

Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds

Michelle Schaefer, Gerhard Schänzle, Daniel Bischoff and Roderich D. Süssmuth
Drug Metabolism and Disposition March 2016, 44 (3) 435-444; DOI: https://doi.org/10.1124/dmd.115.067348
Michelle Schaefer
Department of Drug Discovery Support / Metabolism and Bioanalysis, Boehringer Ingelheim Pharma, Biberach an der Riss, Germany (M.S., G.S., D.B.); and Department of Chemistry, Technische Universität Berlin, Berlin, Germany (R.D.S.)
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Gerhard Schänzle
Department of Drug Discovery Support / Metabolism and Bioanalysis, Boehringer Ingelheim Pharma, Biberach an der Riss, Germany (M.S., G.S., D.B.); and Department of Chemistry, Technische Universität Berlin, Berlin, Germany (R.D.S.)
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Daniel Bischoff
Department of Drug Discovery Support / Metabolism and Bioanalysis, Boehringer Ingelheim Pharma, Biberach an der Riss, Germany (M.S., G.S., D.B.); and Department of Chemistry, Technische Universität Berlin, Berlin, Germany (R.D.S.)
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Roderich D. Süssmuth
Department of Drug Discovery Support / Metabolism and Bioanalysis, Boehringer Ingelheim Pharma, Biberach an der Riss, Germany (M.S., G.S., D.B.); and Department of Chemistry, Technische Universität Berlin, Berlin, Germany (R.D.S.)
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Article Information

vol. 44 no. 3 435-444
DOI 
https://doi.org/10.1124/dmd.115.067348
PubMed 
26712819

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 21, 2015
  • Accepted December 23, 2015
  • Published online February 16, 2016.

Article Versions

  • Earlier version (December 28, 2015 - 10:14).
  • Earlier version (January 19, 2016 - 06:17).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Michelle Schaefer,
  2. Gerhard Schänzle,
  3. Daniel Bischoff, and
  4. Roderich D. Süssmuth
  1. Department of Drug Discovery Support / Metabolism and Bioanalysis, Boehringer Ingelheim Pharma, Biberach an der Riss, Germany (M.S., G.S., D.B.); and Department of Chemistry, Technische Universität Berlin, Berlin, Germany (R.D.S.)
  1. Address correspondence to:
    Dr. Gerhard Schänzle, Department of Drug Discovery Support / Drug Metabolism and Bioanalytics, Boehringer Ingelheim Pharma, Birkendorfer Str. 65, 88397 Biberach an der Riss, Germany. E-mail: gerhard.schaenzle{at}boehringer-ingelheim.com
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Drug Metabolism and Disposition: 44 (3)
Drug Metabolism and Disposition
Vol. 44, Issue 3
1 Mar 2016
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Research ArticleArticle

Upcyte Human Hepatocytes for Prediction of Human Clearance

Michelle Schaefer, Gerhard Schänzle, Daniel Bischoff and Roderich D. Süssmuth
Drug Metabolism and Disposition March 1, 2016, 44 (3) 435-444; DOI: https://doi.org/10.1124/dmd.115.067348

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Research ArticleArticle

Upcyte Human Hepatocytes for Prediction of Human Clearance

Michelle Schaefer, Gerhard Schänzle, Daniel Bischoff and Roderich D. Süssmuth
Drug Metabolism and Disposition March 1, 2016, 44 (3) 435-444; DOI: https://doi.org/10.1124/dmd.115.067348
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