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Research ArticleArticle

Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes

Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
Drug Metabolism and Disposition March 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985

Article Information

vol. 44 no. 3 466-475
DOI 
https://doi.org/10.1124/dmd.115.066985
PubMed 
26684498
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 4, 2015
  • Accepted December 17, 2015
  • Published online February 16, 2016.

Article Versions

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Rucha S. Sane,
  2. Diane Ramsden,
  3. John P. Sabo,
  4. Curtis Cooper,
  5. Lois Rowland,
  6. Naitee Ting,
  7. Andrea Whitcher-Johnstone, and
  8. Donald J. Tweedie
  1. Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (R.S.S, D.R., J.P.S., L.R., N.T., A.W.J, D.J.T) and Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada (C.C.)
  1. Address correspondence to:
    Dr. Rucha S. Sane, Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877. E-mail: rucha.sane{at}boehringer-ingelheim.com
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Research ArticleArticle

P450 DDI of Deleobuvir and Its Metabolites

Rucha S. Sane, Diane Ramsden, John P. Sabo, Curtis Cooper, Lois Rowland, Naitee Ting, Andrea Whitcher-Johnstone and Donald J. Tweedie
Drug Metabolism and Disposition March 1, 2016, 44 (3) 466-475; DOI: https://doi.org/10.1124/dmd.115.066985
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