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In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition

Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
Drug Metabolism and Disposition March 2016, 44 (3) 476-480; DOI: https://doi.org/10.1124/dmd.115.067777

Article Information

vol. 44 no. 3 476-480
DOI 
https://doi.org/10.1124/dmd.115.067777
PubMed 
26842595
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 9, 2015
  • Accepted February 1, 2016
  • Published online February 16, 2016.

Article Versions

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Matthew D. Harwood,
  2. Brahim Achour,
  3. Sibylle Neuhoff,
  4. Matthew R. Russell,
  5. Gordon Carlson,
  6. Geoffrey Warhurst, and
  7. Amin Rostami-Hodjegan
  1. Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (M.D.H., G.C., G.W.); Simcyp Limited (a Certara company), Blades Enterprise Centre, Sheffield, United Kingdom (M.D.H., S.N., A.R.-H.); and Centre for Applied Pharmacokinetic Research, Manchester Pharmacy School, Stopford Building, Manchester, United Kingdom (B.A., M.R.R., A.R.-H.)
  1. Address correspondence to:
    Dr. Matthew D. Harwood, Simcyp Ltd. (a Certara company), Blades Enterprise Centre, John Street, Sheffield S2 4SU, UK. E-mail: matthew.harwood{at}certara.com
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Impact of Cross-Laboratory Differences of Intestinal REF on IVIVE-PBPK

Matthew D. Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R. Russell, Gordon Carlson, Geoffrey Warhurst and Amin Rostami-Hodjegan
Drug Metabolism and Disposition March 1, 2016, 44 (3) 476-480; DOI: https://doi.org/10.1124/dmd.115.067777
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