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Drug Metabolism & Disposition

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Table of Contents

April 01, 2016; Volume 44,Issue 4

Minireview

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    Design and Interpretation of Human Sulfotransferase 1A1 Assays
    Ting Wang, Ian Cook and Thomas S. Leyh
    Drug Metabolism and Disposition April 2016, 44 (4) 481-484; DOI: https://doi.org/10.1124/dmd.115.068205

Symposium Report

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    The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function
    Emily E. Scott, C. Roland Wolf, Michal Otyepka, Sara C. Humphreys, James R. Reed, Colin J. Henderson, Lesley A. McLaughlin, Markéta Paloncýová, Veronika Navrátilová, Karel Berka, Pavel Anzenbacher, Upendra P. Dahal, Carlo Barnaba, James A. Brozik, Jeffrey P. Jones, D. Fernando Estrada, Jennifer S. Laurence, Ji Won Park and Wayne L. Backes
    Drug Metabolism and Disposition April 2016, 44 (4) 576-590; DOI: https://doi.org/10.1124/dmd.115.068569

Articles

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    Efflux Transport Characterization of Resveratrol Glucuronides in UDP-Glucuronosyltransferase 1A1 Transfected HeLa Cells: Application of a Cellular Pharmacokinetic Model to Decipher the Contribution of Multidrug Resistance–Associated Protein 4
    Shuai Wang, Feng Li, Enxi Quan, Dong Dong and Baojian Wu
    Drug Metabolism and Disposition April 2016, 44 (4) 485-488; DOI: https://doi.org/10.1124/dmd.115.067710
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    Effect of Ondansetron on Metformin Pharmacokinetics and Response in Healthy Subjects
    Qing Li, Hong Yang, Dong Guo, Taolan Zhang, James E. Polli, Honghao Zhou and Yan Shu
    Drug Metabolism and Disposition April 2016, 44 (4) 489-494; DOI: https://doi.org/10.1124/dmd.115.067223
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    CYP267A1 and CYP267B1 from Sorangium cellulosum So ce56 are Highly Versatile Drug Metabolizers
    Fredy Kern, Yogan Khatri, Martin Litzenburger and Rita Bernhardt
    Drug Metabolism and Disposition April 2016, 44 (4) 495-504; DOI: https://doi.org/10.1124/dmd.115.068486
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    Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach
    Anna Vildhede, André Mateus, Elin K. Khan, Yurong Lai, Maria Karlgren, Per Artursson and Maria C. Kjellsson
    Drug Metabolism and Disposition April 2016, 44 (4) 505-516; DOI: https://doi.org/10.1124/dmd.115.066746
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    Hepatic Transporter Expression in Metabolic Syndrome: Phenotype, Serum Metabolic Hormones, and Transcription Factor Expression
    Ajay C. Donepudi, Qiuqiong Cheng, Zhenqiang James Lu, Nathan J. Cherrington and Angela L. Slitt
    Drug Metabolism and Disposition April 2016, 44 (4) 518-526; DOI: https://doi.org/10.1124/dmd.115.066779
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    Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG
    Britta Bonn, Petter Svanberg, Annika Janefeldt, Ia Hultman and Ken Grime
    Drug Metabolism and Disposition April 2016, 44 (4) 527-533; DOI: https://doi.org/10.1124/dmd.115.067769
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    Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole
    Jeannine Chan, Tyler Oshiro, Sarah Thomas, Allyson Higa, Stephen Black, Aleksandar Todorovic, Fawzy Elbarbry and John P. Harrelson
    Drug Metabolism and Disposition April 2016, 44 (4) 534-543; DOI: https://doi.org/10.1124/dmd.115.067942
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    Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo
    Brandon T. Gufford, Jessica Bo Li Lu, Ingrid F. Metzger, David R. Jones and Zeruesenay Desta
    Drug Metabolism and Disposition April 2016, 44 (4) 544-553; DOI: https://doi.org/10.1124/dmd.115.068908
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    Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation
    Jian Shi, Xinwen Wang, Jenny Nguyen, Audrey H. Wu, Barry E. Bleske and Hao-Jie Zhu
    Drug Metabolism and Disposition April 2016, 44 (4) 554-559; DOI: https://doi.org/10.1124/dmd.115.068536
  • Biomarkers of Flutamide-Bioactivation and Oxidative Stress In Vitro and In Vivo
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    Biomarkers of Flutamide-Bioactivation and Oxidative Stress In Vitro and In Vivo
    Marieke Teppner, Franziska Boess, Beat Ernst and Axel Pähler
    Drug Metabolism and Disposition April 2016, 44 (4) 560-569; DOI: https://doi.org/10.1124/dmd.115.066522
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    Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation
    Abu J. M. Sadeque, Safet Palamar, Khawja A. Usmani, Chuan Chen, Matthew A. Cerny and Weichao G. Chen
    Drug Metabolism and Disposition April 2016, 44 (4) 570-575; DOI: https://doi.org/10.1124/dmd.115.067397
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    Nonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes
    Elizabeth A. Rondini, Zofia Duniec-Dmuchowski and Thomas A. Kocarek
    Drug Metabolism and Disposition April 2016, 44 (4) 595-604; DOI: https://doi.org/10.1124/dmd.115.068551
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    Identification of Epoxide-Derived Metabolite(s) of Benzbromarone
    Kai Wang, Hui Wang, Ying Peng and Jiang Zheng
    Drug Metabolism and Disposition April 2016, 44 (4) 607-615; DOI: https://doi.org/10.1124/dmd.115.066803

Short Communication

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    Simvastatin Hydroxy Acid Fails to Attain Sufficient Central Nervous System Tumor Exposure to Achieve a Cytotoxic Effect: Results of a Preclinical Cerebral Microdialysis Study
    Yogesh T. Patel, Megan O. Jacus, Abigail D. Davis, Nidal Boulos, David C. Turner, Pradeep K. Vuppala, Burgess B. Freeman, Richard J. Gilbertson and Clinton F. Stewart
    Drug Metabolism and Disposition April 2016, 44 (4) 591-594; DOI: https://doi.org/10.1124/dmd.115.068445

Errata

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    Correction to: “Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers”
    Drug Metabolism and Disposition April 2016, 44 (4) 517; DOI: https://doi.org/10.1124/dmd.114.066506err
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    Correction to “Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain”
    Drug Metabolism and Disposition April 2016, 44 (4) 605; DOI: https://doi.org/10.1124/dmd.115.067439err
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    Correction to: “A Novel Loading Method for Doxycycline Liposomes for Intracellular Drug Delivery: Characterization of In Vitro and In Vivo Release Kinetics and Efficacy in a J774A.1 Cell Line Model of Mycobacterium smegmatis Infection”
    Drug Metabolism and Disposition April 2016, 44 (4) 606; DOI: https://doi.org/10.1124/dmd.115.063602err2
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    Correction to “Design and Interpretation of Human Sulfotransferase A1 Assays”
    Drug Metabolism and Disposition April 2016, 44 (4) 616; DOI: https://doi.org/10.1124/dmd.115.068205err
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Drug Metabolism and Disposition: 44 (4)
Drug Metabolism and Disposition
Vol. 44, Issue 4
1 Apr 2016
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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