Drug Metabolism and Disposition: 44 (4)

April 01, 2016; Volume 44,Issue 4

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Design and Interpretation of Human Sulfotransferase 1A1 Assays
Ting Wang, Ian Cook and Thomas S. Leyh

Drug Metabolism and Disposition April 2016, 44 (4) 481-484; DOI: https://doi.org/10.1124/dmd.115.068205

Symposium Report

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The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function
Emily E. Scott, C. Roland Wolf, Michal Otyepka, Sara C. Humphreys, James R. Reed, Colin J. Henderson, Lesley A. McLaughlin, Markéta Paloncýová, Veronika Navrátilová, Karel Berka, Pavel Anzenbacher, Upendra P. Dahal, Carlo Barnaba, James A. Brozik, Jeffrey P. Jones, D. Fernando Estrada, Jennifer S. Laurence, Ji Won Park and Wayne L. Backes

Drug Metabolism and Disposition April 2016, 44 (4) 576-590; DOI: https://doi.org/10.1124/dmd.115.068569

Articles

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Efflux Transport Characterization of Resveratrol Glucuronides in UDP-Glucuronosyltransferase 1A1 Transfected HeLa Cells: Application of a Cellular Pharmacokinetic Model to Decipher the Contribution of Multidrug Resistance–Associated Protein 4
Shuai Wang, Feng Li, Enxi Quan, Dong Dong and Baojian Wu

Drug Metabolism and Disposition April 2016, 44 (4) 485-488; DOI: https://doi.org/10.1124/dmd.115.067710
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Effect of Ondansetron on Metformin Pharmacokinetics and Response in Healthy Subjects
Qing Li, Hong Yang, Dong Guo, Taolan Zhang, James E. Polli, Honghao Zhou and Yan Shu

Drug Metabolism and Disposition April 2016, 44 (4) 489-494; DOI: https://doi.org/10.1124/dmd.115.067223
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CYP267A1 and CYP267B1 from Sorangium cellulosum So ce56 are Highly Versatile Drug Metabolizers
Fredy Kern, Yogan Khatri, Martin Litzenburger and Rita Bernhardt

Drug Metabolism and Disposition April 2016, 44 (4) 495-504; DOI: https://doi.org/10.1124/dmd.115.068486
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Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach
Anna Vildhede, André Mateus, Elin K. Khan, Yurong Lai, Maria Karlgren, Per Artursson and Maria C. Kjellsson

Drug Metabolism and Disposition April 2016, 44 (4) 505-516; DOI: https://doi.org/10.1124/dmd.115.066746
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Hepatic Transporter Expression in Metabolic Syndrome: Phenotype, Serum Metabolic Hormones, and Transcription Factor Expression
Ajay C. Donepudi, Qiuqiong Cheng, Zhenqiang James Lu, Nathan J. Cherrington and Angela L. Slitt

Drug Metabolism and Disposition April 2016, 44 (4) 518-526; DOI: https://doi.org/10.1124/dmd.115.066779
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Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG
Britta Bonn, Petter Svanberg, Annika Janefeldt, Ia Hultman and Ken Grime

Drug Metabolism and Disposition April 2016, 44 (4) 527-533; DOI: https://doi.org/10.1124/dmd.115.067769
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Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole
Jeannine Chan, Tyler Oshiro, Sarah Thomas, Allyson Higa, Stephen Black, Aleksandar Todorovic, Fawzy Elbarbry and John P. Harrelson

Drug Metabolism and Disposition April 2016, 44 (4) 534-543; DOI: https://doi.org/10.1124/dmd.115.067942
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Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo
Brandon T. Gufford, Jessica Bo Li Lu, Ingrid F. Metzger, David R. Jones and Zeruesenay Desta

Drug Metabolism and Disposition April 2016, 44 (4) 544-553; DOI: https://doi.org/10.1124/dmd.115.068908
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Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation
Jian Shi, Xinwen Wang, Jenny Nguyen, Audrey H. Wu, Barry E. Bleske and Hao-Jie Zhu

Drug Metabolism and Disposition April 2016, 44 (4) 554-559; DOI: https://doi.org/10.1124/dmd.115.068536
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Biomarkers of Flutamide-Bioactivation and Oxidative Stress In Vitro and In Vivo
Marieke Teppner, Franziska Boess, Beat Ernst and Axel Pähler

Drug Metabolism and Disposition April 2016, 44 (4) 560-569; DOI: https://doi.org/10.1124/dmd.115.066522
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Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation
Abu J. M. Sadeque, Safet Palamar, Khawja A. Usmani, Chuan Chen, Matthew A. Cerny and Weichao G. Chen

Drug Metabolism and Disposition April 2016, 44 (4) 570-575; DOI: https://doi.org/10.1124/dmd.115.067397
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Nonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes
Elizabeth A. Rondini, Zofia Duniec-Dmuchowski and Thomas A. Kocarek

Drug Metabolism and Disposition April 2016, 44 (4) 595-604; DOI: https://doi.org/10.1124/dmd.115.068551
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Identification of Epoxide-Derived Metabolite(s) of Benzbromarone
Kai Wang, Hui Wang, Ying Peng and Jiang Zheng

Drug Metabolism and Disposition April 2016, 44 (4) 607-615; DOI: https://doi.org/10.1124/dmd.115.066803

Short Communication

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Simvastatin Hydroxy Acid Fails to Attain Sufficient Central Nervous System Tumor Exposure to Achieve a Cytotoxic Effect: Results of a Preclinical Cerebral Microdialysis Study
Yogesh T. Patel, Megan O. Jacus, Abigail D. Davis, Nidal Boulos, David C. Turner, Pradeep K. Vuppala, Burgess B. Freeman, Richard J. Gilbertson and Clinton F. Stewart

Drug Metabolism and Disposition April 2016, 44 (4) 591-594; DOI: https://doi.org/10.1124/dmd.115.068445

Errata

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Correction to: “Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers”
Drug Metabolism and Disposition April 2016, 44 (4) 517; DOI: https://doi.org/10.1124/dmd.114.066506err
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Correction to “Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain”
Drug Metabolism and Disposition April 2016, 44 (4) 605; DOI: https://doi.org/10.1124/dmd.115.067439err
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Correction to: “A Novel Loading Method for Doxycycline Liposomes for Intracellular Drug Delivery: Characterization of In Vitro and In Vivo Release Kinetics and Efficacy in a J774A.1 Cell Line Model of Mycobacterium smegmatis Infection”
Drug Metabolism and Disposition April 2016, 44 (4) 606; DOI: https://doi.org/10.1124/dmd.115.063602err2
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Correction to “Design and Interpretation of Human Sulfotransferase A1 Assays”
Drug Metabolism and Disposition April 2016, 44 (4) 616; DOI: https://doi.org/10.1124/dmd.115.068205err

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