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Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Anna Vildhede, André Mateus, Elin K. Khan, Yurong Lai, Maria Karlgren, Per Artursson and Maria C. Kjellsson
Drug Metabolism and Disposition April 2016, 44 (4) 505-516; DOI: https://doi.org/10.1124/dmd.115.066746

Article Information

vol. 44 no. 4 505-516
DOI 
https://doi.org/10.1124/dmd.115.066746
PubMed 
26842596
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 12, 2015
  • Accepted February 1, 2016
  • Published online February 26, 2016.

Article Versions

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anna Vildhede,
  2. André Mateus,
  3. Elin K. Khan,
  4. Yurong Lai,
  5. Maria Karlgren,
  6. Per Artursson, and
  7. Maria C. Kjellsson
  1. Department of Pharmacy (A.V., A.M., E.K.K., M.K., P.A.), Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University (M.C.K.), and Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Chemical Biology Consortium, Science for Life Laboratory (P.A.), Uppsala, Sweden; and Bristol-Myers Squibb, Princeton, New Jersey (Y.L.)
  1. Address correspondence to:
    Maria C. Kjellsson, Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden.
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A Bottom-Up Mechanistic Model for Hepatic Transport

Anna Vildhede, André Mateus, Elin K. Khan, Yurong Lai, Maria Karlgren, Per Artursson and Maria C. Kjellsson
Drug Metabolism and Disposition April 1, 2016, 44 (4) 505-516; DOI: https://doi.org/10.1124/dmd.115.066746
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