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Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG

Britta Bonn, Petter Svanberg, Annika Janefeldt, Ia Hultman and Ken Grime
Drug Metabolism and Disposition April 2016, 44 (4) 527-533; DOI: https://doi.org/10.1124/dmd.115.067769

Article Information

vol. 44 no. 4 527-533
DOI 
https://doi.org/10.1124/dmd.115.067769
PubMed 
26851239
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 10, 2015
  • Accepted February 4, 2016
  • Published online March 1, 2016.

Article Versions

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Britta Bonn,
  2. Petter Svanberg,
  3. Annika Janefeldt,
  4. Ia Hultman, and
  5. Ken Grime
  1. RIA iMED DMPK (B.B., P.S., K.G.), CVMD iMED DMPK (A.J.), Drug Safety and Metabolism (I.H.), AstraZeneca R&D, Gothenburg, Sweden
  1. Address correspondence to:
    Dr. Britta Bonn. RIA iMED DMPK, AstraZeneca R&D Gothenburg, SE-431 81 Gothenburg, Sweden. E-mail: Britta.Bonn{at}astrazeneca.com
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Research ArticleArticle

Low Intrinsic Clearance in Plated Hepatocytes and HepaRG

Britta Bonn, Petter Svanberg, Annika Janefeldt, Ia Hultman and Ken Grime
Drug Metabolism and Disposition April 1, 2016, 44 (4) 527-533; DOI: https://doi.org/10.1124/dmd.115.067769
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