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Research ArticleArticle

Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole

Jeannine Chan, Tyler Oshiro, Sarah Thomas, Allyson Higa, Stephen Black, Aleksandar Todorovic, Fawzy Elbarbry and John P. Harrelson
Drug Metabolism and Disposition April 2016, 44 (4) 534-543; DOI: https://doi.org/10.1124/dmd.115.067942
Jeannine Chan
Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.C., T.O., A.H., S.B.); and School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (S.T., A.H., S.B., A.T., F.E., J.P.H.)
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Tyler Oshiro
Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.C., T.O., A.H., S.B.); and School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (S.T., A.H., S.B., A.T., F.E., J.P.H.)
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Sarah Thomas
Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.C., T.O., A.H., S.B.); and School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (S.T., A.H., S.B., A.T., F.E., J.P.H.)
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Allyson Higa
Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.C., T.O., A.H., S.B.); and School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (S.T., A.H., S.B., A.T., F.E., J.P.H.)
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Stephen Black
Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.C., T.O., A.H., S.B.); and School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (S.T., A.H., S.B., A.T., F.E., J.P.H.)
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Aleksandar Todorovic
Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.C., T.O., A.H., S.B.); and School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (S.T., A.H., S.B., A.T., F.E., J.P.H.)
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Fawzy Elbarbry
Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.C., T.O., A.H., S.B.); and School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (S.T., A.H., S.B., A.T., F.E., J.P.H.)
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John P. Harrelson
Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.C., T.O., A.H., S.B.); and School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (S.T., A.H., S.B., A.T., F.E., J.P.H.)
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Article Information

vol. 44 no. 4 534-543
DOI 
https://doi.org/10.1124/dmd.115.067942
PubMed 
26851241

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 16, 2015
  • Accepted February 4, 2016
  • Published online March 1, 2016.

Article Versions

  • Earlier version (February 5, 2016 - 05:50).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jeannine Chan,
  2. Tyler Oshiro,
  3. Sarah Thomas,
  4. Allyson Higa,
  5. Stephen Black,
  6. Aleksandar Todorovic,
  7. Fawzy Elbarbry, and
  8. John P. Harrelson
  1. Chemistry Department, Pacific University Oregon, Forest Grove, Oregon (J.C., T.O., A.H., S.B.); and School of Pharmacy, Pacific University Oregon, Hillsboro, Oregon (S.T., A.H., S.B., A.T., F.E., J.P.H.)
  1. Address correspondence to:
    Dr. John P. Harrelson, School of Pharmacy, Pacific University Oregon, 222 SE 8th Avenue, Ste 451, Hillsboro, OR 97123. E-mail: harrelsonj{at}pacificu.edu
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Drug Metabolism and Disposition: 44 (4)
Drug Metabolism and Disposition
Vol. 44, Issue 4
1 Apr 2016
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Research ArticleArticle

CYP2A6 Inhibition by Cinnamic Aldehyde

Jeannine Chan, Tyler Oshiro, Sarah Thomas, Allyson Higa, Stephen Black, Aleksandar Todorovic, Fawzy Elbarbry and John P. Harrelson
Drug Metabolism and Disposition April 1, 2016, 44 (4) 534-543; DOI: https://doi.org/10.1124/dmd.115.067942

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Research ArticleArticle

CYP2A6 Inhibition by Cinnamic Aldehyde

Jeannine Chan, Tyler Oshiro, Sarah Thomas, Allyson Higa, Stephen Black, Aleksandar Todorovic, Fawzy Elbarbry and John P. Harrelson
Drug Metabolism and Disposition April 1, 2016, 44 (4) 534-543; DOI: https://doi.org/10.1124/dmd.115.067942
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