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Drug Metabolism & Disposition

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Table of Contents

May 01, 2016; Volume 44,Issue 5

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    Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper
    Eugenia Kraynov, Amrita V. Kamath, Markus Walles, Edit Tarcsa, Antoine Deslandes, Ramaswamy A. Iyer, Amita Datta-Mannan, Priya Sriraman, Michaela Bairlein, Johnny J. Yang, Matthew Barfield, Guangqing Xiao, Enrique Escandon, Weirong Wang, Dan A. Rock, Nagendra V. Chemuturi and David J. Moore
    Drug Metabolism and Disposition May 2016, 44 (5) 617-623; DOI: https://doi.org/10.1124/dmd.115.068049

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    Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations
    Thomas I.F.H. Cremers, Gunnar Flik, Joost H.A. Folgering, Hans Rollema and Robert E. Stratford
    Drug Metabolism and Disposition May 2016, 44 (5) 624-633; DOI: https://doi.org/10.1124/dmd.115.068932
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    Biosynthesis of Fluorinated Analogs of Drugs Using Human Cytochrome P450 Enzymes Followed by Deoxyfluorination and Quantitative Nuclear Magnetic Resonance Spectroscopy to Improve Metabolic Stability
    R. Scott Obach, Gregory S. Walker and Michael A. Brodney
    Drug Metabolism and Disposition May 2016, 44 (5) 634-646; DOI: https://doi.org/10.1124/dmd.116.069310
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    Schisandra sphenanthera Extract Facilitates Liver Regeneration after Partial Hepatectomy in Mice
    Xi Li, Xiaomei Fan, Dongshun Li, Xuezhen Zeng, Hang Zeng, Yongtao Wang, Yawen Zhou, Yixin Chen, Min Huang and Huichang Bi
    Drug Metabolism and Disposition May 2016, 44 (5) 647-652; DOI: https://doi.org/10.1124/dmd.115.068288
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    Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans
    Su-Er W. Huskey, Chun-qi Zhu, Melissa M. Lin, Ry R. Forseth, Helen Gu, Oliver Simon, Fabian K. Eggimann, Matthias Kittelmann, Alexandre Luneau, Alexandra Vargas, Hongmei Li, Lai Wang, Heidi J. Einolf, Jin Zhang, Sarah Favara, Handan He and James B. Mangold
    Drug Metabolism and Disposition May 2016, 44 (5) 653-664; DOI: https://doi.org/10.1124/dmd.115.069112
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    Epidermal Growth Factor Receptor Kinase Inhibitors Synergize with TCDD to Induce CYP1A1/1A2 in Human Breast Epithelial MCF10A Cells
    Aby Joiakim, Patricia A. Mathieu, Catherine Shelp, Julie Boerner and John J. Reiners
    Drug Metabolism and Disposition May 2016, 44 (5) 665-671; DOI: https://doi.org/10.1124/dmd.115.066274
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    KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects
    Su-Er W. Huskey, Chun-qi Zhu, Andreas Fredenhagen, Jürgen Kühnöl, Alexandre Luneau, Zhigang Jian, Ziping Yang, Zhuang Miao, Fan Yang, Jay P. Jain, Gangadhar Sunkara, James B. Mangold and Daniel S. Stein
    Drug Metabolism and Disposition May 2016, 44 (5) 672-682; DOI: https://doi.org/10.1124/dmd.115.069187
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    The Consequence of Drug–Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices
    Ming Li, Inge A. M. de Graaf, Sanna Siissalo, Marina H. de Jager, Annie van Dam and Geny M. M. Groothuis
    Drug Metabolism and Disposition May 2016, 44 (5) 683-691; DOI: https://doi.org/10.1124/dmd.115.068684
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    The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide–Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy
    Heather Eng, Renato J. Scialis, Charles J. Rotter, Jian Lin, Sarah Lazzaro, Manthena V. Varma, Li Di, Bo Feng, Michael West and Amit S. Kalgutkar
    Drug Metabolism and Disposition May 2016, 44 (5) 692-699; DOI: https://doi.org/10.1124/dmd.115.067447
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    The ABCG2 Efflux Transporter in the Mammary Gland Mediates Veterinary Drug Secretion across the Blood-Milk Barrier into Milk of Dairy Cows
    Hanna Mahnke, Mariana Ballent, Sven Baumann, Fernanda Imperiale, Martin von Bergen, Carlos Lanusse, Adrian L. Lifschitz, Walther Honscha and Sandra Halwachs
    Drug Metabolism and Disposition May 2016, 44 (5) 700-708; DOI: https://doi.org/10.1124/dmd.115.068940
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    Endotoxin-Mediated Downregulation of Hepatic Drug Transporters in HIV-1 Transgenic Rats
    Ragia H. Ghoneim and Micheline Piquette-Miller
    Drug Metabolism and Disposition May 2016, 44 (5) 709-719; DOI: https://doi.org/10.1124/dmd.115.067827
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    Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α–Mediated Apoptosis
    Tingting Yan, Hong Wang, Min Zhao, Tomoki Yagai, Yingying Chai, Kristopher W. Krausz, Cen Xie, Xuefang Cheng, Jun Zhang, Yuan Che, Feiyan Li, Yuzheng Wu, Chad N. Brocker, Frank J. Gonzalez, Guangji Wang and Haiping Hao
    Drug Metabolism and Disposition May 2016, 44 (5) 720-731; DOI: https://doi.org/10.1124/dmd.116.069419
  • Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data
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    Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data
    Jessica Iegre, Martin A. Hayes, Richard A. Thompson, Lars Weidolf and Emre M. Isin
    Drug Metabolism and Disposition May 2016, 44 (5) 732-740; DOI: https://doi.org/10.1124/dmd.115.067850
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    Immobilized Cytochrome P450 for Monitoring of P450-P450 Interactions and Metabolism
    Chris D. Bostick, Katherine M. Hickey, Lance A. Wollenberg, Darcy R. Flora, Timothy S. Tracy and Peter M. Gannett
    Drug Metabolism and Disposition May 2016, 44 (5) 741-749; DOI: https://doi.org/10.1124/dmd.115.067637
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    RETRACTION: CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids
    Muhammad Farooq, Edward J. Kelly and Jashvant D. Unadkat
    Drug Metabolism and Disposition May 2016, 44 (5) 750-757; DOI: https://doi.org/10.1124/dmd.115.069229
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    Integrin Receptors Play a Key Role in the Regulation of Hepatic CYP3A
    Kristina Jonsson-Schmunk, Piynauch Wonganan, Jin Huk Choi, Shellie M. Callahan and Maria A. Croyle
    Drug Metabolism and Disposition May 2016, 44 (5) 758-770; DOI: https://doi.org/10.1124/dmd.115.068874
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    Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Toward Endogenous Substrates
    Yan Zhao, Debin Wan, Jun Yang, Bruce D. Hammock and Paul R. Ortiz de Montellano
    Drug Metabolism and Disposition May 2016, 44 (5) 771-780; DOI: https://doi.org/10.1124/dmd.116.069633
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    Mechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data
    Hoa Q. Nguyen, Emi Kimoto, Ernesto Callegari and R. Scott Obach
    Drug Metabolism and Disposition May 2016, 44 (5) 781-791; DOI: https://doi.org/10.1124/dmd.115.068601
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Drug Metabolism and Disposition: 44 (5)
Drug Metabolism and Disposition
Vol. 44, Issue 5
1 May 2016
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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