Drug Metabolism and Disposition: 44 (5)

May 01, 2016; Volume 44,Issue 5

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Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper
Eugenia Kraynov, Amrita V. Kamath, Markus Walles, Edit Tarcsa, Antoine Deslandes, Ramaswamy A. Iyer, Amita Datta-Mannan, Priya Sriraman, Michaela Bairlein, Johnny J. Yang, Matthew Barfield, Guangqing Xiao, Enrique Escandon, Weirong Wang, Dan A. Rock, Nagendra V. Chemuturi and David J. Moore

Drug Metabolism and Disposition May 2016, 44 (5) 617-623; DOI: https://doi.org/10.1124/dmd.115.068049

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Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations
Thomas I.F.H. Cremers, Gunnar Flik, Joost H.A. Folgering, Hans Rollema and Robert E. Stratford

Drug Metabolism and Disposition May 2016, 44 (5) 624-633; DOI: https://doi.org/10.1124/dmd.115.068932
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Biosynthesis of Fluorinated Analogs of Drugs Using Human Cytochrome P450 Enzymes Followed by Deoxyfluorination and Quantitative Nuclear Magnetic Resonance Spectroscopy to Improve Metabolic Stability
R. Scott Obach, Gregory S. Walker and Michael A. Brodney

Drug Metabolism and Disposition May 2016, 44 (5) 634-646; DOI: https://doi.org/10.1124/dmd.116.069310
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Schisandra sphenanthera Extract Facilitates Liver Regeneration after Partial Hepatectomy in Mice
Xi Li, Xiaomei Fan, Dongshun Li, Xuezhen Zeng, Hang Zeng, Yongtao Wang, Yawen Zhou, Yixin Chen, Min Huang and Huichang Bi

Drug Metabolism and Disposition May 2016, 44 (5) 647-652; DOI: https://doi.org/10.1124/dmd.115.068288
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Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans
Su-Er W. Huskey, Chun-qi Zhu, Melissa M. Lin, Ry R. Forseth, Helen Gu, Oliver Simon, Fabian K. Eggimann, Matthias Kittelmann, Alexandre Luneau, Alexandra Vargas, Hongmei Li, Lai Wang, Heidi J. Einolf, Jin Zhang, Sarah Favara, Handan He and James B. Mangold

Drug Metabolism and Disposition May 2016, 44 (5) 653-664; DOI: https://doi.org/10.1124/dmd.115.069112
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Epidermal Growth Factor Receptor Kinase Inhibitors Synergize with TCDD to Induce CYP1A1/1A2 in Human Breast Epithelial MCF10A Cells
Aby Joiakim, Patricia A. Mathieu, Catherine Shelp, Julie Boerner and John J. Reiners

Drug Metabolism and Disposition May 2016, 44 (5) 665-671; DOI: https://doi.org/10.1124/dmd.115.066274
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KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [¹⁴C]KAE609 in Healthy Male Subjects
Su-Er W. Huskey, Chun-qi Zhu, Andreas Fredenhagen, Jürgen Kühnöl, Alexandre Luneau, Zhigang Jian, Ziping Yang, Zhuang Miao, Fan Yang, Jay P. Jain, Gangadhar Sunkara, James B. Mangold and Daniel S. Stein

Drug Metabolism and Disposition May 2016, 44 (5) 672-682; DOI: https://doi.org/10.1124/dmd.115.069187
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The Consequence of Drug–Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices
Ming Li, Inge A. M. de Graaf, Sanna Siissalo, Marina H. de Jager, Annie van Dam and Geny M. M. Groothuis

Drug Metabolism and Disposition May 2016, 44 (5) 683-691; DOI: https://doi.org/10.1124/dmd.115.068684
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The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide–Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy
Heather Eng, Renato J. Scialis, Charles J. Rotter, Jian Lin, Sarah Lazzaro, Manthena V. Varma, Li Di, Bo Feng, Michael West and Amit S. Kalgutkar

Drug Metabolism and Disposition May 2016, 44 (5) 692-699; DOI: https://doi.org/10.1124/dmd.115.067447
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The ABCG2 Efflux Transporter in the Mammary Gland Mediates Veterinary Drug Secretion across the Blood-Milk Barrier into Milk of Dairy Cows
Hanna Mahnke, Mariana Ballent, Sven Baumann, Fernanda Imperiale, Martin von Bergen, Carlos Lanusse, Adrian L. Lifschitz, Walther Honscha and Sandra Halwachs

Drug Metabolism and Disposition May 2016, 44 (5) 700-708; DOI: https://doi.org/10.1124/dmd.115.068940
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Endotoxin-Mediated Downregulation of Hepatic Drug Transporters in HIV-1 Transgenic Rats
Ragia H. Ghoneim and Micheline Piquette-Miller

Drug Metabolism and Disposition May 2016, 44 (5) 709-719; DOI: https://doi.org/10.1124/dmd.115.067827
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Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α–Mediated Apoptosis
Tingting Yan, Hong Wang, Min Zhao, Tomoki Yagai, Yingying Chai, Kristopher W. Krausz, Cen Xie, Xuefang Cheng, Jun Zhang, Yuan Che, Feiyan Li, Yuzheng Wu, Chad N. Brocker, Frank J. Gonzalez, Guangji Wang and Haiping Hao

Drug Metabolism and Disposition May 2016, 44 (5) 720-731; DOI: https://doi.org/10.1124/dmd.116.069419
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Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data
Jessica Iegre, Martin A. Hayes, Richard A. Thompson, Lars Weidolf and Emre M. Isin

Drug Metabolism and Disposition May 2016, 44 (5) 732-740; DOI: https://doi.org/10.1124/dmd.115.067850
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Immobilized Cytochrome P450 for Monitoring of P450-P450 Interactions and Metabolism
Chris D. Bostick, Katherine M. Hickey, Lance A. Wollenberg, Darcy R. Flora, Timothy S. Tracy and Peter M. Gannett

Drug Metabolism and Disposition May 2016, 44 (5) 741-749; DOI: https://doi.org/10.1124/dmd.115.067637
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RETRACTION: CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids
Muhammad Farooq, Edward J. Kelly and Jashvant D. Unadkat

Drug Metabolism and Disposition May 2016, 44 (5) 750-757; DOI: https://doi.org/10.1124/dmd.115.069229
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Integrin Receptors Play a Key Role in the Regulation of Hepatic CYP3A
Kristina Jonsson-Schmunk, Piynauch Wonganan, Jin Huk Choi, Shellie M. Callahan and Maria A. Croyle

Drug Metabolism and Disposition May 2016, 44 (5) 758-770; DOI: https://doi.org/10.1124/dmd.115.068874
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Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Toward Endogenous Substrates
Yan Zhao, Debin Wan, Jun Yang, Bruce D. Hammock and Paul R. Ortiz de Montellano

Drug Metabolism and Disposition May 2016, 44 (5) 771-780; DOI: https://doi.org/10.1124/dmd.116.069633
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Mechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data
Hoa Q. Nguyen, Emi Kimoto, Ernesto Callegari and R. Scott Obach

Drug Metabolism and Disposition May 2016, 44 (5) 781-791; DOI: https://doi.org/10.1124/dmd.115.068601

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