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Research ArticleArticle

KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects

Su-Er W. Huskey, Chun-qi Zhu, Andreas Fredenhagen, Jürgen Kühnöl, Alexandre Luneau, Zhigang Jian, Ziping Yang, Zhuang Miao, Fan Yang, Jay P. Jain, Gangadhar Sunkara, James B. Mangold and Daniel S. Stein
Drug Metabolism and Disposition May 2016, 44 (5) 672-682; DOI: https://doi.org/10.1124/dmd.115.069187
Su-Er W. Huskey
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Chun-qi Zhu
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Andreas Fredenhagen
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Jürgen Kühnöl
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Alexandre Luneau
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Zhigang Jian
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Ziping Yang
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Zhuang Miao
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Fan Yang
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Jay P. Jain
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Gangadhar Sunkara
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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James B. Mangold
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Daniel S. Stein
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
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Article Information

vol. 44 no. 5 672-682
DOI 
https://doi.org/10.1124/dmd.115.069187
PubMed 
26921387

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 23, 2015
  • Accepted February 19, 2016
  • Published online April 1, 2016.

Article Versions

  • Earlier version (February 26, 2016 - 06:27).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Su-Er W. Huskey,
  2. Chun-qi Zhu,
  3. Andreas Fredenhagen,
  4. Jürgen Kühnöl,
  5. Alexandre Luneau,
  6. Zhigang Jian,
  7. Ziping Yang,
  8. Zhuang Miao,
  9. Fan Yang,
  10. Jay P. Jain,
  11. Gangadhar Sunkara,
  12. James B. Mangold, and
  13. Daniel S. Stein
  1. Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
  1. Address correspondence to:
    Su-Er W. Huskey, Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, One Health Plaza, East Hanover, NJ 07936-1080. E-mail: su.huskey{at}novartis.com
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Drug Metabolism and Disposition: 44 (5)
Drug Metabolism and Disposition
Vol. 44, Issue 5
1 May 2016
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Research ArticleArticle

ADME of KAE609, a Potent Antimalarial Agent, in Humans

Su-Er W. Huskey, Chun-qi Zhu, Andreas Fredenhagen, Jürgen Kühnöl, Alexandre Luneau, Zhigang Jian, Ziping Yang, Zhuang Miao, Fan Yang, Jay P. Jain, Gangadhar Sunkara, James B. Mangold and Daniel S. Stein
Drug Metabolism and Disposition May 1, 2016, 44 (5) 672-682; DOI: https://doi.org/10.1124/dmd.115.069187

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Research ArticleArticle

ADME of KAE609, a Potent Antimalarial Agent, in Humans

Su-Er W. Huskey, Chun-qi Zhu, Andreas Fredenhagen, Jürgen Kühnöl, Alexandre Luneau, Zhigang Jian, Ziping Yang, Zhuang Miao, Fan Yang, Jay P. Jain, Gangadhar Sunkara, James B. Mangold and Daniel S. Stein
Drug Metabolism and Disposition May 1, 2016, 44 (5) 672-682; DOI: https://doi.org/10.1124/dmd.115.069187
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