Research ArticleArticle
KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects
Su-Er W. Huskey, Chun-qi Zhu, Andreas Fredenhagen, Jürgen Kühnöl, Alexandre Luneau, Zhigang Jian, Ziping Yang, Zhuang Miao, Fan Yang, Jay P. Jain, Gangadhar Sunkara, James B. Mangold and Daniel S. Stein
Drug Metabolism and Disposition May 2016, 44 (5) 672-682; DOI: https://doi.org/10.1124/dmd.115.069187
Su-Er W. Huskey
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Chun-qi Zhu
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Andreas Fredenhagen
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Jürgen Kühnöl
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Alexandre Luneau
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Zhigang Jian
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Ziping Yang
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Zhuang Miao
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Fan Yang
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Jay P. Jain
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Gangadhar Sunkara
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
James B. Mangold
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)
Daniel S. Stein
Drug Metabolism and Pharmacokinetics (S.W.H., C.Z., Z.J., Z.Y., Z.M., J.P.J., G.S., J.B.M) and Translational Medicine (F.Y., D.S.S.), Novartis Institutes for Biomedical Research, East Hanover, New Jersey; and Global Discovery Chemistry, Basel, Switzerland (A.F., J.K., A.L.)

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Research ArticleArticle
ADME of KAE609, a Potent Antimalarial Agent, in Humans
Su-Er W. Huskey, Chun-qi Zhu, Andreas Fredenhagen, Jürgen Kühnöl, Alexandre Luneau, Zhigang Jian, Ziping Yang, Zhuang Miao, Fan Yang, Jay P. Jain, Gangadhar Sunkara, James B. Mangold and Daniel S. Stein
Drug Metabolism and Disposition May 1, 2016, 44 (5) 672-682; DOI: https://doi.org/10.1124/dmd.115.069187
Research ArticleArticle
ADME of KAE609, a Potent Antimalarial Agent, in Humans
Su-Er W. Huskey, Chun-qi Zhu, Andreas Fredenhagen, Jürgen Kühnöl, Alexandre Luneau, Zhigang Jian, Ziping Yang, Zhuang Miao, Fan Yang, Jay P. Jain, Gangadhar Sunkara, James B. Mangold and Daniel S. Stein
Drug Metabolism and Disposition May 1, 2016, 44 (5) 672-682; DOI: https://doi.org/10.1124/dmd.115.069187