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Drug Metabolism & Disposition

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Table of Contents

June 01, 2016; Volume 44,Issue 6

Articles

  • You have access
    Effect of Rifampin on the Disposition of Brivaracetam in Human Subjects: Further Insights into Brivaracetam Hydrolysis
    Armel Stockis, Shikiko Watanabe, André J. Scheen, Dominique Tytgat, Brigitte Gerin, Maria Rosa, Hugues Chanteux and Jean-Marie Nicolas
    Drug Metabolism and Disposition June 2016, 44 (6) 792-799; DOI: https://doi.org/10.1124/dmd.115.069161
  • You have access
    An Integrated Approach for Studying Exposure, Metabolism, and Disposition of Multiple Component Herbal Medicines Using High-Resolution Mass Spectrometry and Multiple Data Processing Tools
    Caisheng Wu, Haiying Zhang, Caihong Wang, Hailin Qin, Mingshe Zhu and Jinlan Zhang
    Drug Metabolism and Disposition June 2016, 44 (6) 800-808; DOI: https://doi.org/10.1124/dmd.115.068189
  • Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine <em>δ</em>-Oxidation and Rearrangement
    You have access
    Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement
    Wenying Li, Weiping Zhao, Xiaohong Liu, Xiaohua Huang, Omar D. Lopez, John E. Leet, R. Marcus Fancher, Van Nguyen, Jason Goodrich, John Easter, Yang Hong, Janet Caceres-Cortes, Shu Y. Chang, Li Ma, Makonen Belema, Lawrence G. Hamann, Min Gao, Mingshe Zhu, Yue-Zhong Shu, W. Griffith Humphreys and Benjamin M. Johnson
    Drug Metabolism and Disposition June 2016, 44 (6) 809-820; DOI: https://doi.org/10.1124/dmd.115.068866
  • Open Access
    Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model
    Lisa M. Almond, Sophie Mukadam, Iain Gardner, Krystle Okialda, Susan Wong, Oliver Hatley, Suzanne Tay, Karen Rowland-Yeo, Masoud Jamei, Amin Rostami-Hodjegan and Jane R. Kenny
    Drug Metabolism and Disposition June 2016, 44 (6) 821-832; DOI: https://doi.org/10.1124/dmd.115.066845
  • A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine
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    A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine
    Shotaro Uehara, Yasuhiro Uno, Yukako Yuki, Takashi Inoue, Erika Sasaki and Hiroshi Yamazaki
    Drug Metabolism and Disposition June 2016, 44 (6) 833-841; DOI: https://doi.org/10.1124/dmd.116.070367
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    RNA Sequencing Quantification of Xenobiotic-Processing Genes in Various Sections of the Intestine in Comparison to the Liver of Male Mice
    Zidong Donna Fu, Felcy Pavithra Selwyn, Julia Yue Cui and Curtis D. Klaassen
    Drug Metabolism and Disposition June 2016, 44 (6) 842-856; DOI: https://doi.org/10.1124/dmd.115.068270
  • You have access
    Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4)
    Mark A. Csandl, Gwenaëlle Conseil and Susan P. C. Cole
    Drug Metabolism and Disposition June 2016, 44 (6) 857-866; DOI: https://doi.org/10.1124/dmd.116.069468
  • p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38
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    p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38
    Takeshi Hori, Rick Moore and Masahiko Negishi
    Drug Metabolism and Disposition June 2016, 44 (6) 871-876; DOI: https://doi.org/10.1124/dmd.116.070235

Short Communication

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    Hepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in Sandwich-Cultured Human Hepatocytes
    Yang Lu, Jason R. Slizgi, Kenneth R. Brouwer, Robert L. St. Claire, Kimberly M. Freeman, Maxwell Pan, William J. Brock and Kim L. R. Brouwer
    Drug Metabolism and Disposition June 2016, 44 (6) 867-870; DOI: https://doi.org/10.1124/dmd.115.067629

Erratum

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    Correction to “Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model”
    Drug Metabolism and Disposition June 2016, 44 (6) 877; DOI: https://doi.org/10.1124/dmd.115.066845err
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Drug Metabolism and Disposition: 44 (6)
Drug Metabolism and Disposition
Vol. 44, Issue 6
1 Jun 2016
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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