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Hepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in Sandwich-Cultured Human Hepatocytes

Yang Lu, Jason R. Slizgi, Kenneth R. Brouwer, Robert L. St. Claire, Kimberly M. Freeman, Maxwell Pan, William J. Brock and Kim L. R. Brouwer
Drug Metabolism and Disposition June 2016, 44 (6) 867-870; DOI: https://doi.org/10.1124/dmd.115.067629

Article Information

vol. 44 no. 6 867-870
DOI 
https://doi.org/10.1124/dmd.115.067629
PubMed 
27013400
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 16, 2105
  • Accepted March 21, 2016
  • Published online May 2, 2016.

Article Versions

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yang Lu,
  2. Jason R. Slizgi,
  3. Kenneth R. Brouwer,
  4. Robert L. St. Claire,
  5. Kimberly M. Freeman,
  6. Maxwell Pan,
  7. William J. Brock, and
  8. Kim L. R. Brouwer
  1. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (Y.L., J.R.S., K.L.R.B); Qualyst Transporter Solutions, Durham, North Carolina (K.R.B., R.L.S.C., K.M.F); Otsuka PDC, Inc., Rockville, Maryland (M.P.); Brock Scientific Consulting, Montgomery Village, Maryland (W.J.B.)
  1. Address correspondence to:
    Dr. Kim L. R. Brouwer, Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 301 Pharmacy Lane CB #7569 Kerr Hall, Chapel Hill, NC 27599. E-mail: kbrouwer{at}unc.edu
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Rapid CommunicationShort Communication

Tolvaptan Disposition and DDIs in SCHH

Yang Lu, Jason R. Slizgi, Kenneth R. Brouwer, Robert L. St. Claire, Kimberly M. Freeman, Maxwell Pan, William J. Brock and Kim L. R. Brouwer
Drug Metabolism and Disposition June 1, 2016, 44 (6) 867-870; DOI: https://doi.org/10.1124/dmd.115.067629
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